Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et al.]

Background: Metabolic syndrome (MS) is a cluster of abdominal obesity, atherogenic dyslipidaemia, hypertension and insulin resistance with or without hyperglycaemia associated with increased risk of coronary heart diseases. There may be a possible link between MS, central obesity and increased marke...

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Main Authors:	Mohd Nawawi, Hapizah, Tengku Ismail, Tengku Saifudin, S. Krishnapilla, Ambigga devi, Ramli, Anis Safura, T. Osman, Muhammad
Format:	Research Reports
Language:	English
Published:	Research Management Institute (RMI) 2011
Online Access:	http://ir.uitm.edu.my/id/eprint/18679/ http://ir.uitm.edu.my/id/eprint/18679/1/LP_HAPIZAH%20MOHD%20NAWAWI%20RMI%2011_5.pdf

id	uitm-18679
recordtype	eprints
spelling	uitm-186792018-07-05T02:26:10Z http://ir.uitm.edu.my/id/eprint/18679/ Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et al.] Mohd Nawawi, Hapizah Tengku Ismail, Tengku Saifudin S. Krishnapilla, Ambigga devi Ramli, Anis Safura T. Osman, Muhammad Background: Metabolic syndrome (MS) is a cluster of abdominal obesity, atherogenic dyslipidaemia, hypertension and insulin resistance with or without hyperglycaemia associated with increased risk of coronary heart diseases. There may be a possible link between MS, central obesity and increased markers of oxidative stress. The oxidative stress in central obesity and MS with different glycaemic status is still unclear. Objective: The aim of our study was to evaluate the oxidative stress in central obesity and MS subjects with different glycaemic status and subjects with central obesity without MS. Design: A total of 260 subjects (Mean±SD : 53±11, 66 Males) were randomly recruited and divided into 5 groups: central obesity without MS (OBXMS), MS with diabetes (MSDM), MS with impaired fasting glucose (MSIFG), MS with normoglycaemia (MSNG) and normal control (NC). In addition, MSDM, MSIFG and MSNG were grouped as all MS group with a total number of 156. The blood levels of oxidized low-density lipoprotein (oxLDL) and 8-Isoprostane were evaluated. Results: OBXMS group was not significantly different compared to NC group. MSDM group compared to NC group had higher 8-Isoprostane (p<0.001).MSIFG group compared to NC group had higher oxLDL (p<0.001) and 8-Isoprostane (p<0.001). MSNG group compared to NC group had higher 8-Isoprostane (p<0.001). All MS group compared to NC group had higher oxLDL (p<0.05) and 8-Isoprostane (p<0.001). All MS group compared to OBXMS group had higher 8-Isoprostane (p<0.001). Conclusions: MS irrespective of glycaemic status has enhanced oxidative stress compared to controls. There is enhanced oxidative stress in central obesity especially in the presence of MS, suggesting high coronary risk of MS subjects. Research Management Institute (RMI) 2011 Research Reports NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/18679/1/LP_HAPIZAH%20MOHD%20NAWAWI%20RMI%2011_5.pdf Mohd Nawawi, Hapizah and Tengku Ismail, Tengku Saifudin and S. Krishnapilla, Ambigga devi and Ramli, Anis Safura and T. Osman, Muhammad (2011) Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et al.]. [Research Reports] (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
description	Background: Metabolic syndrome (MS) is a cluster of abdominal obesity, atherogenic dyslipidaemia, hypertension and insulin resistance with or without hyperglycaemia associated with increased risk of coronary heart diseases. There may be a possible link between MS, central obesity and increased markers of oxidative stress. The oxidative stress in central obesity and MS with different glycaemic status is still unclear. Objective: The aim of our study was to evaluate the oxidative stress in central obesity and MS subjects with different glycaemic status and subjects with central obesity without MS. Design: A total of 260 subjects (Mean±SD : 53±11, 66 Males) were randomly recruited and divided into 5 groups: central obesity without MS (OBXMS), MS with diabetes (MSDM), MS with impaired fasting glucose (MSIFG), MS with normoglycaemia (MSNG) and normal control (NC). In addition, MSDM, MSIFG and MSNG were grouped as all MS group with a total number of 156. The blood levels of oxidized low-density lipoprotein (oxLDL) and 8-Isoprostane were evaluated. Results: OBXMS group was not significantly different compared to NC group. MSDM group compared to NC group had higher 8-Isoprostane (p<0.001).MSIFG group compared to NC group had higher oxLDL (p<0.001) and 8-Isoprostane (p<0.001). MSNG group compared to NC group had higher 8-Isoprostane (p<0.001). All MS group compared to NC group had higher oxLDL (p<0.05) and 8-Isoprostane (p<0.001). All MS group compared to OBXMS group had higher 8-Isoprostane (p<0.001). Conclusions: MS irrespective of glycaemic status has enhanced oxidative stress compared to controls. There is enhanced oxidative stress in central obesity especially in the presence of MS, suggesting high coronary risk of MS subjects.
format	Research Reports
author	Mohd Nawawi, Hapizah Tengku Ismail, Tengku Saifudin S. Krishnapilla, Ambigga devi Ramli, Anis Safura T. Osman, Muhammad
spellingShingle	Mohd Nawawi, Hapizah Tengku Ismail, Tengku Saifudin S. Krishnapilla, Ambigga devi Ramli, Anis Safura T. Osman, Muhammad Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et al.]
author_facet	Mohd Nawawi, Hapizah Tengku Ismail, Tengku Saifudin S. Krishnapilla, Ambigga devi Ramli, Anis Safura T. Osman, Muhammad
author_sort	Mohd Nawawi, Hapizah
title	Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et al.]
title_short	Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et al.]
title_full	Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et al.]
title_fullStr	Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et al.]
title_full_unstemmed	Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et al.]
title_sort	oxidative stress in metabolic syndrome / profesor dr. hapizah mohd nawawi … [et al.]
publisher	Research Management Institute (RMI)
publishDate	2011
url	http://ir.uitm.edu.my/id/eprint/18679/ http://ir.uitm.edu.my/id/eprint/18679/1/LP_HAPIZAH%20MOHD%20NAWAWI%20RMI%2011_5.pdf
first_indexed	2023-09-18T23:01:04Z
last_indexed	2023-09-18T23:01:04Z
_version_	1777418177005748224

Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et al.]

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