Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar

The project focused on the use of microwave in controlling drug release from film matrix and modifying skin barrier for transdermal drug delivery. With reference to controlledrelease application, the effects of microwave on drug release properties of pectin films carrying sulfanilamide (P-SN), sulfa...

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Main Author:	Anuar, Nor Khaizan
Format:	Book Section
Language:	English
Published:	Institute of Graduate Studies, UiTM 2013
Subjects:	Malaysia Materia medica
Online Access:	http://ir.uitm.edu.my/id/eprint/19130/ http://ir.uitm.edu.my/id/eprint/19130/1/ABS_NOR%20KHAIZAN%20ANUAR%20TDRA%20VOL%204%20IGS%2013.pdf

id	uitm-19130
recordtype	eprints
spelling	uitm-191302018-06-11T04:33:25Z http://ir.uitm.edu.my/id/eprint/19130/ Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar Anuar, Nor Khaizan Malaysia Materia medica The project focused on the use of microwave in controlling drug release from film matrix and modifying skin barrier for transdermal drug delivery. With reference to controlledrelease application, the effects of microwave on drug release properties of pectin films carrying sulfanilamide (P-SN), sulfathiazole (P-ST) and sulfamerazine (P-SM) of high to low aqueous solubilities were investigated. These films were prepared by solvent-evaporation technique and treated by microwave at 80 W for 5 to 40 min. Their profiles of drug dissolution, drug content, matrix interaction and matrix crystallinity were determined by drug dissolution testing, drug content assay, differential scanning calorimetry, X-ray diffractometry and scanning electron microscopy techniques. Microwave was found to be able to increase the matrix amorphousness. However, the strength of matrix interaction was accordingly increased thereby lowering the drug release propensity with a greater retardation extent in P-SN films. A gain in amorphous structure did not necessarily increase the drug release of film. Microwave can possibly retard drug release of pectin film carrying water-soluble drug through modulating its state of matrix interaction. In the case of skin barrier modification by microwave, the mechanism of microwave enhancing transdermal permeation of drug from film through its action on skin was investigated. The transdermal drug delivery profiles of pectin film was evaluated against pectin gel with reference to the influences of microwave, as well as chemical permeation enhancer namely oleic acid on skin. Hydrophilic P-SN films and gels, with or without oleic acid (OA), were prepared and subjected to drug release and skin permeation studies… Institute of Graduate Studies, UiTM 2013 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/19130/1/ABS_NOR%20KHAIZAN%20ANUAR%20TDRA%20VOL%204%20IGS%2013.pdf Anuar, Nor Khaizan (2013) Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar. In: The Doctoral Research Abstracts. IPSis Biannual Publication, 4 (4). Institute of Graduate Studies, UiTM, Shah Alam.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Malaysia Materia medica
spellingShingle	Malaysia Materia medica Anuar, Nor Khaizan Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar
description	The project focused on the use of microwave in controlling drug release from film matrix and modifying skin barrier for transdermal drug delivery. With reference to controlledrelease application, the effects of microwave on drug release properties of pectin films carrying sulfanilamide (P-SN), sulfathiazole (P-ST) and sulfamerazine (P-SM) of high to low aqueous solubilities were investigated. These films were prepared by solvent-evaporation technique and treated by microwave at 80 W for 5 to 40 min. Their profiles of drug dissolution, drug content, matrix interaction and matrix crystallinity were determined by drug dissolution testing, drug content assay, differential scanning calorimetry, X-ray diffractometry and scanning electron microscopy techniques. Microwave was found to be able to increase the matrix amorphousness. However, the strength of matrix interaction was accordingly increased thereby lowering the drug release propensity with a greater retardation extent in P-SN films. A gain in amorphous structure did not necessarily increase the drug release of film. Microwave can possibly retard drug release of pectin film carrying water-soluble drug through modulating its state of matrix interaction. In the case of skin barrier modification by microwave, the mechanism of microwave enhancing transdermal permeation of drug from film through its action on skin was investigated. The transdermal drug delivery profiles of pectin film was evaluated against pectin gel with reference to the influences of microwave, as well as chemical permeation enhancer namely oleic acid on skin. Hydrophilic P-SN films and gels, with or without oleic acid (OA), were prepared and subjected to drug release and skin permeation studies…
format	Book Section
author	Anuar, Nor Khaizan
author_facet	Anuar, Nor Khaizan
author_sort	Anuar, Nor Khaizan
title	Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar
title_short	Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar
title_full	Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar
title_fullStr	Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar
title_full_unstemmed	Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar
title_sort	use of microwave technology in transdermal drug delivery / nor khaizan anuar
publisher	Institute of Graduate Studies, UiTM
publishDate	2013
url	http://ir.uitm.edu.my/id/eprint/19130/ http://ir.uitm.edu.my/id/eprint/19130/1/ABS_NOR%20KHAIZAN%20ANUAR%20TDRA%20VOL%204%20IGS%2013.pdf
first_indexed	2023-09-18T23:01:55Z
last_indexed	2023-09-18T23:01:55Z
_version_	1777418229845590016

Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar

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