Development of a multifaceted (MECSUS) protocol in the search for novel bioactive entities from microorganisms / Rasha Saad Abd Elgadir Soliman

Development of a multifaceted (MECSUS) protocol in the search for novel bioactive entities from microorganisms / Rasha Saad Abd Elgadir Soliman

The advent of new chemical genetic tools and high-throughput screening technologies and platforms have already led and will continue to lead in accessing the natural product diversity of microorganisms. This thesis represents a continuation of the work on the investigation into means of making bette...

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Main Author: Abd Elgadir Soliman, Rasha Saad Abd Elgadir Soliman
Format: Book Section
Language:English
Published: Institute of Graduate Studies, UiTM 2013
Subjects:
QR Microbiology
Online Access:http://ir.uitm.edu.my/id/eprint/19133/
http://ir.uitm.edu.my/id/eprint/19133/1/ABS_RASHA%20SAAD%20ABD%20ELGADIR%20SOLIMAN%20TDRA%20VOL%204%20IGS%2013.pdf
id uitm-19133
recordtype eprints
spelling uitm-191332019-02-04T05:50:12Z http://ir.uitm.edu.my/id/eprint/19133/ Development of a multifaceted (MECSUS) protocol in the search for novel bioactive entities from microorganisms / Rasha Saad Abd Elgadir Soliman Abd Elgadir Soliman, Rasha Saad Abd Elgadir Soliman QR Microbiology The advent of new chemical genetic tools and high-throughput screening technologies and platforms have already led and will continue to lead in accessing the natural product diversity of microorganisms. This thesis represents a continuation of the work on the investigation into means of making better use of the advantages of new technologies and the OSMAC approach (One Strain Many Compounds) in drug discovery that the Atta-ur-Rahman Research Institute of Natural Product Discovery (RiND) at MARA University of Technology has engaged in. The result of this thesis is the MECSUS (Microtiter plate, Elicitors, Combination, Solid phase extraction, UHPLC, Statistical analysis) protocol. It involves miniaturized parallel fermentations in 96-well microtiter plate with up to ninety six different media, parallel extraction of the supernatant layer of the fungus via a polymer based solid phase extraction (SPE) plate, chromatographic assessment of the results via UHPLC, and multivariate analysis of the chromatograms… Institute of Graduate Studies, UiTM 2013 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/19133/1/ABS_RASHA%20SAAD%20ABD%20ELGADIR%20SOLIMAN%20TDRA%20VOL%204%20IGS%2013.pdf Abd Elgadir Soliman, Rasha Saad Abd Elgadir Soliman (2013) Development of a multifaceted (MECSUS) protocol in the search for novel bioactive entities from microorganisms / Rasha Saad Abd Elgadir Soliman. In: The Doctoral Research Abstracts. IPSis Biannual Publication, 4 (4). Institute of Graduate Studies, UiTM, Shah Alam.
repository_type Digital Repository
institution_category Local University
institution Universiti Teknologi MARA
building UiTM Institutional Repository
collection Online Access
language English
topic QR Microbiology
spellingShingle QR Microbiology
Abd Elgadir Soliman, Rasha Saad Abd Elgadir Soliman
Development of a multifaceted (MECSUS) protocol in the search for novel bioactive entities from microorganisms / Rasha Saad Abd Elgadir Soliman
description The advent of new chemical genetic tools and high-throughput screening technologies and platforms have already led and will continue to lead in accessing the natural product diversity of microorganisms. This thesis represents a continuation of the work on the investigation into means of making better use of the advantages of new technologies and the OSMAC approach (One Strain Many Compounds) in drug discovery that the Atta-ur-Rahman Research Institute of Natural Product Discovery (RiND) at MARA University of Technology has engaged in. The result of this thesis is the MECSUS (Microtiter plate, Elicitors, Combination, Solid phase extraction, UHPLC, Statistical analysis) protocol. It involves miniaturized parallel fermentations in 96-well microtiter plate with up to ninety six different media, parallel extraction of the supernatant layer of the fungus via a polymer based solid phase extraction (SPE) plate, chromatographic assessment of the results via UHPLC, and multivariate analysis of the chromatograms…
format Book Section
author Abd Elgadir Soliman, Rasha Saad Abd Elgadir Soliman
author_facet Abd Elgadir Soliman, Rasha Saad Abd Elgadir Soliman
author_sort Abd Elgadir Soliman, Rasha Saad Abd Elgadir Soliman
title Development of a multifaceted (MECSUS) protocol in the search for novel bioactive entities from microorganisms / Rasha Saad Abd Elgadir Soliman
title_short Development of a multifaceted (MECSUS) protocol in the search for novel bioactive entities from microorganisms / Rasha Saad Abd Elgadir Soliman
title_full Development of a multifaceted (MECSUS) protocol in the search for novel bioactive entities from microorganisms / Rasha Saad Abd Elgadir Soliman
title_fullStr Development of a multifaceted (MECSUS) protocol in the search for novel bioactive entities from microorganisms / Rasha Saad Abd Elgadir Soliman
title_full_unstemmed Development of a multifaceted (MECSUS) protocol in the search for novel bioactive entities from microorganisms / Rasha Saad Abd Elgadir Soliman
title_sort development of a multifaceted (mecsus) protocol in the search for novel bioactive entities from microorganisms / rasha saad abd elgadir soliman
publisher Institute of Graduate Studies, UiTM
publishDate 2013
url http://ir.uitm.edu.my/id/eprint/19133/
http://ir.uitm.edu.my/id/eprint/19133/1/ABS_RASHA%20SAAD%20ABD%20ELGADIR%20SOLIMAN%20TDRA%20VOL%204%20IGS%2013.pdf
first_indexed 2023-09-18T23:01:55Z
last_indexed 2023-09-18T23:01:55Z
_version_ 1777418230136045568

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