Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James

Alzheimer’s disease (AD) is the most common form of dementia. Until recently, AD is managed by relieving the cognitive symptoms without addressing one of the purportedly fundamental causes of the disease which is the formation of the amyloid plaques. The deposition and aggregation of β-amyloid are k...

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Main Author:	James, Richard Muhammad Johari
Format:	Book Section
Language:	English
Published:	Institute of Graduate Studies, UiTM 2014
Subjects:	Malaysia RC Internal Medicine
Online Access:	http://ir.uitm.edu.my/id/eprint/19246/ http://ir.uitm.edu.my/id/eprint/19246/1/ABS_RICHARD%20MUHAMMAD%20JOHARI%20JAMES%20TDRA%20VOL%205%20IGS_14.pdf

id	uitm-19246
recordtype	eprints
spelling	uitm-192462018-06-12T07:18:04Z http://ir.uitm.edu.my/id/eprint/19246/ Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James James, Richard Muhammad Johari Malaysia RC Internal Medicine Alzheimer’s disease (AD) is the most common form of dementia. Until recently, AD is managed by relieving the cognitive symptoms without addressing one of the purportedly fundamental causes of the disease which is the formation of the amyloid plaques. The deposition and aggregation of β-amyloid are key events in the onset, progression and pathogenesis of AD. Thus one of the emerging strategies in treating AD is to inhibit the enzyme responsible for the formation of amyloid plaques, which is β-site amyloid cleaving enzyme (BACE-1). Endophytes are currently viewed as an outstanding source of bioactive natural products and may provide BACE-1 inhibitors as potential drug candidates for the treatment of AD. A novel bioactive compound, F70HAB16 was successfully isolated from a local endophytic strain and was found to inhibit the BACE-1 enzyme in vitro (IC50=13 μM). Oral treatment with 5 mg/kg of F70HAB16 for 14 days in scopolamine-induced memory deficit mice model was found to restore memory impairment caused by scopolamine in the radial arm maze and Morris water maze (MWM) tasks. Institute of Graduate Studies, UiTM 2014 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/19246/1/ABS_RICHARD%20MUHAMMAD%20JOHARI%20JAMES%20TDRA%20VOL%205%20IGS_14.pdf James, Richard Muhammad Johari (2014) Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James. In: The Doctoral Research Abstracts. IPSis Biannual Publication, 5 (5). Institute of Graduate Studies, UiTM, Shah Alam.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Malaysia RC Internal Medicine
spellingShingle	Malaysia RC Internal Medicine James, Richard Muhammad Johari Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
description	Alzheimer’s disease (AD) is the most common form of dementia. Until recently, AD is managed by relieving the cognitive symptoms without addressing one of the purportedly fundamental causes of the disease which is the formation of the amyloid plaques. The deposition and aggregation of β-amyloid are key events in the onset, progression and pathogenesis of AD. Thus one of the emerging strategies in treating AD is to inhibit the enzyme responsible for the formation of amyloid plaques, which is β-site amyloid cleaving enzyme (BACE-1). Endophytes are currently viewed as an outstanding source of bioactive natural products and may provide BACE-1 inhibitors as potential drug candidates for the treatment of AD. A novel bioactive compound, F70HAB16 was successfully isolated from a local endophytic strain and was found to inhibit the BACE-1 enzyme in vitro (IC50=13 μM). Oral treatment with 5 mg/kg of F70HAB16 for 14 days in scopolamine-induced memory deficit mice model was found to restore memory impairment caused by scopolamine in the radial arm maze and Morris water maze (MWM) tasks.
format	Book Section
author	James, Richard Muhammad Johari
author_facet	James, Richard Muhammad Johari
author_sort	James, Richard Muhammad Johari
title	Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
title_short	Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
title_full	Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
title_fullStr	Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
title_full_unstemmed	Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
title_sort	modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (f70hab16) from malaysian endophyte cytospora rhizophorae, in murine models for alzheimer’s disease / richard muhammad johari james
publisher	Institute of Graduate Studies, UiTM
publishDate	2014
url	http://ir.uitm.edu.my/id/eprint/19246/ http://ir.uitm.edu.my/id/eprint/19246/1/ABS_RICHARD%20MUHAMMAD%20JOHARI%20JAMES%20TDRA%20VOL%205%20IGS_14.pdf
first_indexed	2023-09-18T23:02:09Z
last_indexed	2023-09-18T23:02:09Z
_version_	1777418245077204992

Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James

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