Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim

Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim

Raised leptin levels have been reported in placentae and serum of women with elevated blood pressure and proteinuria during pregnancy. The role of leptin in this however remains unclear. ACE2 is a new member in RAAS, which is reported to have hypotensive and anti-inflammatory effect and its suppress...

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Bibliographic Details
Main Author: Ibrahim, Hisham Saleh
Format: Book Section
Language:English
Published: Institute of Graduate Studies, UiTM 2014
Subjects:
Malaysia
Online Access:http://ir.uitm.edu.my/id/eprint/19615/
http://ir.uitm.edu.my/id/eprint/19615/1/ABS_HISHAM%20SALEH%20IBRAHIM%20TDRA%20VOL%206%20IGS_14.pdf
id uitm-19615
recordtype eprints
spelling uitm-196152018-06-07T02:42:49Z http://ir.uitm.edu.my/id/eprint/19615/ Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim Ibrahim, Hisham Saleh Malaysia Raised leptin levels have been reported in placentae and serum of women with elevated blood pressure and proteinuria during pregnancy. The role of leptin in this however remains unclear. ACE2 is a new member in RAAS, which is reported to have hypotensive and anti-inflammatory effect and its suppression leads to increased blood pressure and endothelial activation. Therefore, this study investigated the effect of leptin and xanthenone (ACE2 activator) administration on systolic blood pressure (SBP), proteinuria and serum markers of endothelial activation during pregnancy in Sprague-Dawley rats. Eighty female Sprague-Dawley rats, aged 12- 13 weeks were randomised into 10 groups, Group 1 acted as a control non-pregnant group and given saline (NSNP). Institute of Graduate Studies, UiTM 2014 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/19615/1/ABS_HISHAM%20SALEH%20IBRAHIM%20TDRA%20VOL%206%20IGS_14.pdf Ibrahim, Hisham Saleh (2014) Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim. In: The Doctoral Research Abstracts. IPSis Biannual Publication, 6 (6). Institute of Graduate Studies, UiTM, Shah Alam.
repository_type Digital Repository
institution_category Local University
institution Universiti Teknologi MARA
building UiTM Institutional Repository
collection Online Access
language English
topic Malaysia
spellingShingle Malaysia
Ibrahim, Hisham Saleh
Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim
description Raised leptin levels have been reported in placentae and serum of women with elevated blood pressure and proteinuria during pregnancy. The role of leptin in this however remains unclear. ACE2 is a new member in RAAS, which is reported to have hypotensive and anti-inflammatory effect and its suppression leads to increased blood pressure and endothelial activation. Therefore, this study investigated the effect of leptin and xanthenone (ACE2 activator) administration on systolic blood pressure (SBP), proteinuria and serum markers of endothelial activation during pregnancy in Sprague-Dawley rats. Eighty female Sprague-Dawley rats, aged 12- 13 weeks were randomised into 10 groups, Group 1 acted as a control non-pregnant group and given saline (NSNP).
format Book Section
author Ibrahim, Hisham Saleh
author_facet Ibrahim, Hisham Saleh
author_sort Ibrahim, Hisham Saleh
title Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim
title_short Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim
title_full Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim
title_fullStr Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim
title_full_unstemmed Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim
title_sort effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / hisham saleh ibrahim
publisher Institute of Graduate Studies, UiTM
publishDate 2014
url http://ir.uitm.edu.my/id/eprint/19615/
http://ir.uitm.edu.my/id/eprint/19615/1/ABS_HISHAM%20SALEH%20IBRAHIM%20TDRA%20VOL%206%20IGS_14.pdf
first_indexed 2023-09-18T23:02:56Z
last_indexed 2023-09-18T23:02:56Z
_version_ 1777418294370762752

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