Skin delivery of 5-fluorouracil via ethosomes using microwave as skin permeation enhancement technique / Nauman Rahim Khan

Skin delivery of 5-fluorouracil via ethosomes using microwave as skin permeation enhancement technique / Nauman Rahim Khan

This project focused on formulation and investigation of interplay effects of ethosomes, ethanol and microwave for enhanced skin drug retention with minimal systemic absorption. The microwave was used to modify the skin barrier properties to enhance ethosomes and/or drug penetration/and drug retenti...

Full description

Bibliographic Details
Main Author: Rahim Khan, Nauman
Format: Book Section
Language:English
Published: Institute of Graduate Studies, UiTM 2017
Subjects:
Malaysia
Online Access:http://ir.uitm.edu.my/id/eprint/19782/
http://ir.uitm.edu.my/id/eprint/19782/1/ABS_NAUMAN%20RAHIM%20KHAN%20TDRA%20VOL%2011%20IGS%2017.pdf
id uitm-19782
recordtype eprints
spelling uitm-197822018-06-07T08:07:48Z http://ir.uitm.edu.my/id/eprint/19782/ Skin delivery of 5-fluorouracil via ethosomes using microwave as skin permeation enhancement technique / Nauman Rahim Khan Rahim Khan, Nauman Malaysia This project focused on formulation and investigation of interplay effects of ethosomes, ethanol and microwave for enhanced skin drug retention with minimal systemic absorption. The microwave was used to modify the skin barrier properties to enhance ethosomes and/or drug penetration/and drug retention which is detrimental to treat local malignant melanoma and to enhance patient compliance. Ethosomes are known to fuse with skin to enable local drug retention. Pre-treatment of skin with microwave and applying liquified medicine is deemed to “cement” the skin thereby raising skin drug deposition. 5-fluorouracil loaded ethosomes were prepared and subjected physicochemical characterization. The molecular characteristics of untreated, microwave and/or ethosomes and/or ethanol-treated skins were examined by ATR-FTIR and raman spectroscopy, DSC and SEM techniques. The skin drug retention was promoted using larger ethosomes with negative zeta potentials that repelled anionic lipids of skin and hindered vesicle and/or anionic drug penetration into deep layers. Due to low ethanol, they were less able to fluidize the lipid and defluidize the protein domains at epidermis to enlarge aqueous pores for drug permeation. Pre-treatment of skin by 2450 MHz microwave for 2.5 min further increased skin drug penetration and retention of E5 ethosomes and provided lower drug permeation than cases treated for 1.15 min and 5 min. Pre-treating skin with microwave fluidized lipid and defluidized protein domains of skin that promoted transdermal drug penetration… Institute of Graduate Studies, UiTM 2017 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/19782/1/ABS_NAUMAN%20RAHIM%20KHAN%20TDRA%20VOL%2011%20IGS%2017.pdf Rahim Khan, Nauman (2017) Skin delivery of 5-fluorouracil via ethosomes using microwave as skin permeation enhancement technique / Nauman Rahim Khan. In: The Doctoral Research Abstracts. IGS Biannual Publication, 11 (11). Institute of Graduate Studies, UiTM, Shah Alam.
repository_type Digital Repository
institution_category Local University
institution Universiti Teknologi MARA
building UiTM Institutional Repository
collection Online Access
language English
topic Malaysia
spellingShingle Malaysia
Rahim Khan, Nauman
Skin delivery of 5-fluorouracil via ethosomes using microwave as skin permeation enhancement technique / Nauman Rahim Khan
description This project focused on formulation and investigation of interplay effects of ethosomes, ethanol and microwave for enhanced skin drug retention with minimal systemic absorption. The microwave was used to modify the skin barrier properties to enhance ethosomes and/or drug penetration/and drug retention which is detrimental to treat local malignant melanoma and to enhance patient compliance. Ethosomes are known to fuse with skin to enable local drug retention. Pre-treatment of skin with microwave and applying liquified medicine is deemed to “cement” the skin thereby raising skin drug deposition. 5-fluorouracil loaded ethosomes were prepared and subjected physicochemical characterization. The molecular characteristics of untreated, microwave and/or ethosomes and/or ethanol-treated skins were examined by ATR-FTIR and raman spectroscopy, DSC and SEM techniques. The skin drug retention was promoted using larger ethosomes with negative zeta potentials that repelled anionic lipids of skin and hindered vesicle and/or anionic drug penetration into deep layers. Due to low ethanol, they were less able to fluidize the lipid and defluidize the protein domains at epidermis to enlarge aqueous pores for drug permeation. Pre-treatment of skin by 2450 MHz microwave for 2.5 min further increased skin drug penetration and retention of E5 ethosomes and provided lower drug permeation than cases treated for 1.15 min and 5 min. Pre-treating skin with microwave fluidized lipid and defluidized protein domains of skin that promoted transdermal drug penetration…
format Book Section
author Rahim Khan, Nauman
author_facet Rahim Khan, Nauman
author_sort Rahim Khan, Nauman
title Skin delivery of 5-fluorouracil via ethosomes using microwave as skin permeation enhancement technique / Nauman Rahim Khan
title_short Skin delivery of 5-fluorouracil via ethosomes using microwave as skin permeation enhancement technique / Nauman Rahim Khan
title_full Skin delivery of 5-fluorouracil via ethosomes using microwave as skin permeation enhancement technique / Nauman Rahim Khan
title_fullStr Skin delivery of 5-fluorouracil via ethosomes using microwave as skin permeation enhancement technique / Nauman Rahim Khan
title_full_unstemmed Skin delivery of 5-fluorouracil via ethosomes using microwave as skin permeation enhancement technique / Nauman Rahim Khan
title_sort skin delivery of 5-fluorouracil via ethosomes using microwave as skin permeation enhancement technique / nauman rahim khan
publisher Institute of Graduate Studies, UiTM
publishDate 2017
url http://ir.uitm.edu.my/id/eprint/19782/
http://ir.uitm.edu.my/id/eprint/19782/1/ABS_NAUMAN%20RAHIM%20KHAN%20TDRA%20VOL%2011%20IGS%2017.pdf
first_indexed 2023-09-18T23:03:17Z
last_indexed 2023-09-18T23:03:17Z
_version_ 1777418315850842112

Similar Items