Solubility enhancement of statin-based molecules by arginine: thermodynamics, solute-solvent interaction and solid state characterization / Meor Mohd Redzuan Meor Mohd Affandi

Solubility enhancement of statin-based molecules by arginine: thermodynamics, solute-solvent interaction and solid state characterization / Meor Mohd Redzuan Meor Mohd Affandi

Categorized as a Biopharmaceutics Classification System (BCS) Class II drugs, statins exhibit low aqueous solubility and bioavailability thus presenting an obstacle and great challenge to formulation researchers. As a consequence, abundant studies are available in regard to the solubility enhancemen...

Full description

Bibliographic Details
Main Author: Meor Mohd Affandi, Meor Mohd Redzuan
Format: Book Section
Language:English
Published: Institute of Graduate Studies, UiTM 2016
Subjects:
Malaysia
Online Access:http://ir.uitm.edu.my/id/eprint/19924/
http://ir.uitm.edu.my/id/eprint/19924/1/ABS_MEOR%20MOHD%20REDZUAN%20MEOR%20MOHD%20AFFANDI%20TDRA%20VOL%2010%20IGS%2016.pdf
id uitm-19924
recordtype eprints
spelling uitm-199242018-06-11T02:43:49Z http://ir.uitm.edu.my/id/eprint/19924/ Solubility enhancement of statin-based molecules by arginine: thermodynamics, solute-solvent interaction and solid state characterization / Meor Mohd Redzuan Meor Mohd Affandi Meor Mohd Affandi, Meor Mohd Redzuan Malaysia Categorized as a Biopharmaceutics Classification System (BCS) Class II drugs, statins exhibit low aqueous solubility and bioavailability thus presenting an obstacle and great challenge to formulation researchers. As a consequence, abundant studies are available in regard to the solubility enhancement of statins but very few actually describe this phenomenon in terms of thermodynamics and the solute solvent interaction. The present study aimed to elucidate the solute-solvent and solute-cosolute interactions, solid state characteristics, wetting behaviour, surface energy and thermodynamic parameters that bolstered the solubility of simvastatin (SMV) and atorvastatin (ATV) in the presence of ARG. First, the solubility of SMV and ATV in 0.01, 0.02, 0.04, 0.09, 0.18, 0.36 and 0.73 mol dm-3 arginine (ARG) in water solutions was determined. These solutions were subjected to conductometric, volumetric, viscometric, acoustic and refractometric measurements at temperatures (T) of 298.15, 303.15, 308.15 and 313.15 K. Results indicated that there was a massive increase of SMV and ATV solubility in the presence of ARG as a cosolute. Based on physical characteristics, a strong solute-solvent and solutecosolute interaction has occurred in the SMV-ARG and ATV-ARG binary solution mixture… Institute of Graduate Studies, UiTM 2016 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/19924/1/ABS_MEOR%20MOHD%20REDZUAN%20MEOR%20MOHD%20AFFANDI%20TDRA%20VOL%2010%20IGS%2016.pdf Meor Mohd Affandi, Meor Mohd Redzuan (2016) Solubility enhancement of statin-based molecules by arginine: thermodynamics, solute-solvent interaction and solid state characterization / Meor Mohd Redzuan Meor Mohd Affandi. In: The Doctoral Research Abstracts. IGS Biannual Publication, 10 (10). Institute of Graduate Studies, UiTM, Shah Alam.
repository_type Digital Repository
institution_category Local University
institution Universiti Teknologi MARA
building UiTM Institutional Repository
collection Online Access
language English
topic Malaysia
spellingShingle Malaysia
Meor Mohd Affandi, Meor Mohd Redzuan
Solubility enhancement of statin-based molecules by arginine: thermodynamics, solute-solvent interaction and solid state characterization / Meor Mohd Redzuan Meor Mohd Affandi
description Categorized as a Biopharmaceutics Classification System (BCS) Class II drugs, statins exhibit low aqueous solubility and bioavailability thus presenting an obstacle and great challenge to formulation researchers. As a consequence, abundant studies are available in regard to the solubility enhancement of statins but very few actually describe this phenomenon in terms of thermodynamics and the solute solvent interaction. The present study aimed to elucidate the solute-solvent and solute-cosolute interactions, solid state characteristics, wetting behaviour, surface energy and thermodynamic parameters that bolstered the solubility of simvastatin (SMV) and atorvastatin (ATV) in the presence of ARG. First, the solubility of SMV and ATV in 0.01, 0.02, 0.04, 0.09, 0.18, 0.36 and 0.73 mol dm-3 arginine (ARG) in water solutions was determined. These solutions were subjected to conductometric, volumetric, viscometric, acoustic and refractometric measurements at temperatures (T) of 298.15, 303.15, 308.15 and 313.15 K. Results indicated that there was a massive increase of SMV and ATV solubility in the presence of ARG as a cosolute. Based on physical characteristics, a strong solute-solvent and solutecosolute interaction has occurred in the SMV-ARG and ATV-ARG binary solution mixture…
format Book Section
author Meor Mohd Affandi, Meor Mohd Redzuan
author_facet Meor Mohd Affandi, Meor Mohd Redzuan
author_sort Meor Mohd Affandi, Meor Mohd Redzuan
title Solubility enhancement of statin-based molecules by arginine: thermodynamics, solute-solvent interaction and solid state characterization / Meor Mohd Redzuan Meor Mohd Affandi
title_short Solubility enhancement of statin-based molecules by arginine: thermodynamics, solute-solvent interaction and solid state characterization / Meor Mohd Redzuan Meor Mohd Affandi
title_full Solubility enhancement of statin-based molecules by arginine: thermodynamics, solute-solvent interaction and solid state characterization / Meor Mohd Redzuan Meor Mohd Affandi
title_fullStr Solubility enhancement of statin-based molecules by arginine: thermodynamics, solute-solvent interaction and solid state characterization / Meor Mohd Redzuan Meor Mohd Affandi
title_full_unstemmed Solubility enhancement of statin-based molecules by arginine: thermodynamics, solute-solvent interaction and solid state characterization / Meor Mohd Redzuan Meor Mohd Affandi
title_sort solubility enhancement of statin-based molecules by arginine: thermodynamics, solute-solvent interaction and solid state characterization / meor mohd redzuan meor mohd affandi
publisher Institute of Graduate Studies, UiTM
publishDate 2016
url http://ir.uitm.edu.my/id/eprint/19924/
http://ir.uitm.edu.my/id/eprint/19924/1/ABS_MEOR%20MOHD%20REDZUAN%20MEOR%20MOHD%20AFFANDI%20TDRA%20VOL%2010%20IGS%2016.pdf
first_indexed 2023-09-18T23:03:35Z
last_indexed 2023-09-18T23:03:35Z
_version_ 1777418334923390976

Similar Items