Nanoparticles-in-beads made of alginate and chitosan derivatives as oral insulin carrier / Mulham Alfatama

This project aimed to design nanoparticles-in-beads made of alginate, chitosan and their derivatives as oral insulin carrier. In the first part of the study, the calcium alginate beads were prepared using the vibratory nozzle extrusion microencapsulation technique through concurrent core and coat fo...

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Main Author:	Alfatama, Mulham
Format:	Book Section
Language:	English
Published:	Institute of Graduate Studies, UiTM 2018
Subjects:	Bioactive compounds
Online Access:	http://ir.uitm.edu.my/id/eprint/20555/ http://ir.uitm.edu.my/id/eprint/20555/1/ABS_MULHAM%20ALFATAMA%20TDRA%20VOL%2013%20IGS%2018.pdf

id	uitm-20555
recordtype	eprints
spelling	uitm-205552018-07-06T05:52:36Z http://ir.uitm.edu.my/id/eprint/20555/ Nanoparticles-in-beads made of alginate and chitosan derivatives as oral insulin carrier / Mulham Alfatama Alfatama, Mulham Bioactive compounds This project aimed to design nanoparticles-in-beads made of alginate, chitosan and their derivatives as oral insulin carrier. In the first part of the study, the calcium alginate beads were prepared using the vibratory nozzle extrusion microencapsulation technique through concurrent core and coat formation with chlorpheniramine maleate as a model drug. These beads were coated with chitosan/chitosan-oleic acid conjugate of which the latter was synthesized via covalent reaction. The formability of beads was optimized through varying alginate solution concentration, alginate/chitosan solution flow rate and nozzle vibrational frequency. The size, shape, morphology, swelling, erosion, water uptake, drug content, drug release and matrix molecular profiles of beads were characterized. Spherical discrete coated beads were produced through critical interplay of nozzle vibrational frequency and polymeric solution flow rate. The conjugate-coated beads had their swelling and water uptake tendency negated through the introduction of tripolyphosphate ions as a crosslinking agent to attract the conjugate to the alginate core interface for coacervation to take place. The drug release propensity of tripolyphosphate-crosslinked, chitosan-oleic acid conjugate-coated beads was unexpectedly higher than the uncoated beads. This was attributed to reduced drug-alginate interaction as a result of alginate coacervating with chitosan-oleic acid conjugate and loss of calcium alginate crosslinkage to tripolyphosphate species. In the second part of the study, nanoparticles of simple calcium alginate, calcium alginatestearic acid, and calcium alginate-C18 conjugate were prepared by nanospray drying technique… Institute of Graduate Studies, UiTM 2018 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/20555/1/ABS_MULHAM%20ALFATAMA%20TDRA%20VOL%2013%20IGS%2018.pdf Alfatama, Mulham (2018) Nanoparticles-in-beads made of alginate and chitosan derivatives as oral insulin carrier / Mulham Alfatama. In: The Doctoral Research Abstracts. IGS Biannual Publication, 18 (18). Institute of Graduate Studies, UiTM, Shah Alam.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Bioactive compounds
spellingShingle	Bioactive compounds Alfatama, Mulham Nanoparticles-in-beads made of alginate and chitosan derivatives as oral insulin carrier / Mulham Alfatama
description	This project aimed to design nanoparticles-in-beads made of alginate, chitosan and their derivatives as oral insulin carrier. In the first part of the study, the calcium alginate beads were prepared using the vibratory nozzle extrusion microencapsulation technique through concurrent core and coat formation with chlorpheniramine maleate as a model drug. These beads were coated with chitosan/chitosan-oleic acid conjugate of which the latter was synthesized via covalent reaction. The formability of beads was optimized through varying alginate solution concentration, alginate/chitosan solution flow rate and nozzle vibrational frequency. The size, shape, morphology, swelling, erosion, water uptake, drug content, drug release and matrix molecular profiles of beads were characterized. Spherical discrete coated beads were produced through critical interplay of nozzle vibrational frequency and polymeric solution flow rate. The conjugate-coated beads had their swelling and water uptake tendency negated through the introduction of tripolyphosphate ions as a crosslinking agent to attract the conjugate to the alginate core interface for coacervation to take place. The drug release propensity of tripolyphosphate-crosslinked, chitosan-oleic acid conjugate-coated beads was unexpectedly higher than the uncoated beads. This was attributed to reduced drug-alginate interaction as a result of alginate coacervating with chitosan-oleic acid conjugate and loss of calcium alginate crosslinkage to tripolyphosphate species. In the second part of the study, nanoparticles of simple calcium alginate, calcium alginatestearic acid, and calcium alginate-C18 conjugate were prepared by nanospray drying technique…
format	Book Section
author	Alfatama, Mulham
author_facet	Alfatama, Mulham
author_sort	Alfatama, Mulham
title	Nanoparticles-in-beads made of alginate and chitosan derivatives as oral insulin carrier / Mulham Alfatama
title_short	Nanoparticles-in-beads made of alginate and chitosan derivatives as oral insulin carrier / Mulham Alfatama
title_full	Nanoparticles-in-beads made of alginate and chitosan derivatives as oral insulin carrier / Mulham Alfatama
title_fullStr	Nanoparticles-in-beads made of alginate and chitosan derivatives as oral insulin carrier / Mulham Alfatama
title_full_unstemmed	Nanoparticles-in-beads made of alginate and chitosan derivatives as oral insulin carrier / Mulham Alfatama
title_sort	nanoparticles-in-beads made of alginate and chitosan derivatives as oral insulin carrier / mulham alfatama
publisher	Institute of Graduate Studies, UiTM
publishDate	2018
url	http://ir.uitm.edu.my/id/eprint/20555/ http://ir.uitm.edu.my/id/eprint/20555/1/ABS_MULHAM%20ALFATAMA%20TDRA%20VOL%2013%20IGS%2018.pdf
first_indexed	2023-09-18T23:04:50Z
last_indexed	2023-09-18T23:04:50Z
_version_	1777418413133529088

Nanoparticles-in-beads made of alginate and chitosan derivatives as oral insulin carrier / Mulham Alfatama

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