Tocotrienols may reverse the deleterious effects of nicotine-induced oxidative stress on embryo development in mice / Mohd. Hamim Rajikin … [et al.]

The adverse effects of smoking on reproduction are well documented, yet the current trend of tobacco smoking among women still remains. Approximately 4% of Malaysian population aged ≥15 years are female smokers (WHO Policy, Strategy Advisory Committee for Tobacco Free Initiative Estimated, 2000). In...

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Main Authors:	Rajikin, Mohd. Hamim, Chatterjee, Amar, Mohamed Nor Khan, Nor-Ashikin, Abdul Satar, Nuraliza
Format:	Research Reports
Language:	English
Published:	Research Management Institute (RMI) 2013
Subjects:	Drugs and their actions
Online Access:	http://ir.uitm.edu.my/id/eprint/21079/ http://ir.uitm.edu.my/id/eprint/21079/1/LP_MOHD%20HAMIM%20RAJIKIN%20RMI%2013_5.pdf

id	uitm-21079
recordtype	eprints
spelling	uitm-210792018-08-20T07:16:26Z http://ir.uitm.edu.my/id/eprint/21079/ Tocotrienols may reverse the deleterious effects of nicotine-induced oxidative stress on embryo development in mice / Mohd. Hamim Rajikin … [et al.] Rajikin, Mohd. Hamim Chatterjee, Amar Mohamed Nor Khan, Nor-Ashikin Abdul Satar, Nuraliza Drugs and their actions The adverse effects of smoking on reproduction are well documented, yet the current trend of tobacco smoking among women still remains. Approximately 4% of Malaysian population aged ≥15 years are female smokers (WHO Policy, Strategy Advisory Committee for Tobacco Free Initiative Estimated, 2000). In general, people smoke cigarettes for the psychoactive effects of nicotine where it is believed that nicotine may enhance the sense of well-being, produce arousal or relaxation, help maintain vigilance, or reduce anxiety (Benowitz, 1988). However, nicotine has shown many potential adverse health consequences in reproductive or perinatal disorders including low birth weight, prematurity and spontaneous abortion (Benowitz, 1988), delay in conception (Zenzes, 1995) and the onset of menopause in female smokers (Midgette and Baron, 1990). Therefore, certain components in cigarette smoke may directly or indirectly interfere with embryo development and viability. Nicotine is present in cigarettes in amounts varying from 0.8 to 1.8 mg per cigarette depending on the brand and size of cigarette (Benowitz et al., 1983; Rosa et al., 1992). As much as 1.0 mg of nicotine is recorded to be absorbed by smoking a single cigarette (Barbieri et al., 1986). Nicotine is a toxic alkaloid and is quickly absorbed through the respiratory track, mucosa of the mouth and skin (Gandini et al., 1997). It has also been reported that lung appears to serve up as a reservoir for nicotine, which slows its entry into the arterial circulation, implying that even though almost all of the nicotine inhaled in each puff being absorbed in a few seconds, it may require 30–60 seconds or longer for the nicotine to be fascinated (Brewer et al., 2004). Research Management Institute (RMI) 2013 Research Reports NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/21079/1/LP_MOHD%20HAMIM%20RAJIKIN%20RMI%2013_5.pdf Rajikin, Mohd. Hamim and Chatterjee, Amar and Mohamed Nor Khan, Nor-Ashikin and Abdul Satar, Nuraliza (2013) Tocotrienols may reverse the deleterious effects of nicotine-induced oxidative stress on embryo development in mice / Mohd. Hamim Rajikin … [et al.]. [Research Reports] (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Drugs and their actions
spellingShingle	Drugs and their actions Rajikin, Mohd. Hamim Chatterjee, Amar Mohamed Nor Khan, Nor-Ashikin Abdul Satar, Nuraliza Tocotrienols may reverse the deleterious effects of nicotine-induced oxidative stress on embryo development in mice / Mohd. Hamim Rajikin … [et al.]
description	The adverse effects of smoking on reproduction are well documented, yet the current trend of tobacco smoking among women still remains. Approximately 4% of Malaysian population aged ≥15 years are female smokers (WHO Policy, Strategy Advisory Committee for Tobacco Free Initiative Estimated, 2000). In general, people smoke cigarettes for the psychoactive effects of nicotine where it is believed that nicotine may enhance the sense of well-being, produce arousal or relaxation, help maintain vigilance, or reduce anxiety (Benowitz, 1988). However, nicotine has shown many potential adverse health consequences in reproductive or perinatal disorders including low birth weight, prematurity and spontaneous abortion (Benowitz, 1988), delay in conception (Zenzes, 1995) and the onset of menopause in female smokers (Midgette and Baron, 1990). Therefore, certain components in cigarette smoke may directly or indirectly interfere with embryo development and viability. Nicotine is present in cigarettes in amounts varying from 0.8 to 1.8 mg per cigarette depending on the brand and size of cigarette (Benowitz et al., 1983; Rosa et al., 1992). As much as 1.0 mg of nicotine is recorded to be absorbed by smoking a single cigarette (Barbieri et al., 1986). Nicotine is a toxic alkaloid and is quickly absorbed through the respiratory track, mucosa of the mouth and skin (Gandini et al., 1997). It has also been reported that lung appears to serve up as a reservoir for nicotine, which slows its entry into the arterial circulation, implying that even though almost all of the nicotine inhaled in each puff being absorbed in a few seconds, it may require 30–60 seconds or longer for the nicotine to be fascinated (Brewer et al., 2004).
format	Research Reports
author	Rajikin, Mohd. Hamim Chatterjee, Amar Mohamed Nor Khan, Nor-Ashikin Abdul Satar, Nuraliza
author_facet	Rajikin, Mohd. Hamim Chatterjee, Amar Mohamed Nor Khan, Nor-Ashikin Abdul Satar, Nuraliza
author_sort	Rajikin, Mohd. Hamim
title	Tocotrienols may reverse the deleterious effects of nicotine-induced oxidative stress on embryo development in mice / Mohd. Hamim Rajikin … [et al.]
title_short	Tocotrienols may reverse the deleterious effects of nicotine-induced oxidative stress on embryo development in mice / Mohd. Hamim Rajikin … [et al.]
title_full	Tocotrienols may reverse the deleterious effects of nicotine-induced oxidative stress on embryo development in mice / Mohd. Hamim Rajikin … [et al.]
title_fullStr	Tocotrienols may reverse the deleterious effects of nicotine-induced oxidative stress on embryo development in mice / Mohd. Hamim Rajikin … [et al.]
title_full_unstemmed	Tocotrienols may reverse the deleterious effects of nicotine-induced oxidative stress on embryo development in mice / Mohd. Hamim Rajikin … [et al.]
title_sort	tocotrienols may reverse the deleterious effects of nicotine-induced oxidative stress on embryo development in mice / mohd. hamim rajikin … [et al.]
publisher	Research Management Institute (RMI)
publishDate	2013
url	http://ir.uitm.edu.my/id/eprint/21079/ http://ir.uitm.edu.my/id/eprint/21079/1/LP_MOHD%20HAMIM%20RAJIKIN%20RMI%2013_5.pdf
first_indexed	2023-09-18T23:05:47Z
last_indexed	2023-09-18T23:05:47Z
_version_	1777418473672015872

Tocotrienols may reverse the deleterious effects of nicotine-induced oxidative stress on embryo development in mice / Mohd. Hamim Rajikin … [et al.]

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