Hypoglycemic activity and toxicology studies of ethyl acetate extracts of pereskia bleo leaves / Abdul Mutalib Kasim

Pereskia bleo is a leafy cactus which belongs to Cactaceae family and it is commonly used among the traditional medicine practitioners to prevent or treat diabetes by consuming the leaves. The hypoglycemic activity of ethyl acetate extract obtained from the leaves of Pereskia bleo, the existing plan...

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Main Author:	Kasim, Abdul Mutalib
Format:	Student Project
Language:	English
Published:	Faculty Applied Science 2014
Subjects:	Laboratories. General works Bacteria
Online Access:	http://ir.uitm.edu.my/id/eprint/23475/ http://ir.uitm.edu.my/id/eprint/23475/1/PPb_Abdul%20Mutalib%20Kassim_NS_AS14_5%20Pages.pdf

id	uitm-23475
recordtype	eprints
spelling	uitm-234752019-03-19T02:32:58Z http://ir.uitm.edu.my/id/eprint/23475/ Hypoglycemic activity and toxicology studies of ethyl acetate extracts of pereskia bleo leaves / Abdul Mutalib Kasim Kasim, Abdul Mutalib Laboratories. General works Bacteria Pereskia bleo is a leafy cactus which belongs to Cactaceae family and it is commonly used among the traditional medicine practitioners to prevent or treat diabetes by consuming the leaves. The hypoglycemic activity of ethyl acetate extract obtained from the leaves of Pereskia bleo, the existing plants with no known scientific report on their blood glucose lowering potentials, were investigated using fasting blood glucose level method and oral glucose tolerance test in normoglycemic rats. The extracts were prepared using soxhlet apparatus of dried powdered leaves of the Pereskia bleo by ethyl acetate solution and subsequent purification of the extract using rotary evaporator. The extracts were administered to the animal models via the oral route. Their blood glucose levels were determined using an Accu-Chek Glucometer, at various time intervals. The acute toxicity profiles of ethyl acetate extract of Pereskia bleo leaves were investigated by examining the blood levels of alanine aminotransferase, aspartate aminotransferase, urea and creatinine as well as, the gross examination of liver and kidney. The ethyl acetate extract of Pereskia bleo leaves demonstrate a significant blood glucose lowering activity up to 4 hour with 19% reduction of blood glucose level from initial level in a dose dependent response in normoglycemic rats. It is possible that the extract may act by potentiating the pancreatic secretions or increasing the glucose uptake, its mode of action involved the stimulation of insulin production. The findings indicated that the ethyl acetate extract of Pereskia bleo leaves possess hepatoprotective ability that increase liver function leading to blood glucose lowering in normoglycemic rats. The ethyl acetate extract of Pereskia bleo leaves considered safe to use based on the outcome of acute toxicity study in experimental rats with no significant changes between control and treatment rats. Faculty Applied Science 2014 Student Project NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/23475/1/PPb_Abdul%20Mutalib%20Kassim_NS_AS14_5%20Pages.pdf Kasim, Abdul Mutalib (2014) Hypoglycemic activity and toxicology studies of ethyl acetate extracts of pereskia bleo leaves / Abdul Mutalib Kasim. [Student Project] (Submitted)
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Laboratories. General works Bacteria
spellingShingle	Laboratories. General works Bacteria Kasim, Abdul Mutalib Hypoglycemic activity and toxicology studies of ethyl acetate extracts of pereskia bleo leaves / Abdul Mutalib Kasim
description	Pereskia bleo is a leafy cactus which belongs to Cactaceae family and it is commonly used among the traditional medicine practitioners to prevent or treat diabetes by consuming the leaves. The hypoglycemic activity of ethyl acetate extract obtained from the leaves of Pereskia bleo, the existing plants with no known scientific report on their blood glucose lowering potentials, were investigated using fasting blood glucose level method and oral glucose tolerance test in normoglycemic rats. The extracts were prepared using soxhlet apparatus of dried powdered leaves of the Pereskia bleo by ethyl acetate solution and subsequent purification of the extract using rotary evaporator. The extracts were administered to the animal models via the oral route. Their blood glucose levels were determined using an Accu-Chek Glucometer, at various time intervals. The acute toxicity profiles of ethyl acetate extract of Pereskia bleo leaves were investigated by examining the blood levels of alanine aminotransferase, aspartate aminotransferase, urea and creatinine as well as, the gross examination of liver and kidney. The ethyl acetate extract of Pereskia bleo leaves demonstrate a significant blood glucose lowering activity up to 4 hour with 19% reduction of blood glucose level from initial level in a dose dependent response in normoglycemic rats. It is possible that the extract may act by potentiating the pancreatic secretions or increasing the glucose uptake, its mode of action involved the stimulation of insulin production. The findings indicated that the ethyl acetate extract of Pereskia bleo leaves possess hepatoprotective ability that increase liver function leading to blood glucose lowering in normoglycemic rats. The ethyl acetate extract of Pereskia bleo leaves considered safe to use based on the outcome of acute toxicity study in experimental rats with no significant changes between control and treatment rats.
format	Student Project
author	Kasim, Abdul Mutalib
author_facet	Kasim, Abdul Mutalib
author_sort	Kasim, Abdul Mutalib
title	Hypoglycemic activity and toxicology studies of ethyl acetate extracts of pereskia bleo leaves / Abdul Mutalib Kasim
title_short	Hypoglycemic activity and toxicology studies of ethyl acetate extracts of pereskia bleo leaves / Abdul Mutalib Kasim
title_full	Hypoglycemic activity and toxicology studies of ethyl acetate extracts of pereskia bleo leaves / Abdul Mutalib Kasim
title_fullStr	Hypoglycemic activity and toxicology studies of ethyl acetate extracts of pereskia bleo leaves / Abdul Mutalib Kasim
title_full_unstemmed	Hypoglycemic activity and toxicology studies of ethyl acetate extracts of pereskia bleo leaves / Abdul Mutalib Kasim
title_sort	hypoglycemic activity and toxicology studies of ethyl acetate extracts of pereskia bleo leaves / abdul mutalib kasim
publisher	Faculty Applied Science
publishDate	2014
url	http://ir.uitm.edu.my/id/eprint/23475/ http://ir.uitm.edu.my/id/eprint/23475/1/PPb_Abdul%20Mutalib%20Kassim_NS_AS14_5%20Pages.pdf
first_indexed	2023-09-18T23:10:45Z
last_indexed	2023-09-18T23:10:45Z
_version_	1777418786237841408

Hypoglycemic activity and toxicology studies of ethyl acetate extracts of pereskia bleo leaves / Abdul Mutalib Kasim

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