Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et. al.]

Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et. al.]

Background: Metabolic syndrome (MS) is a cluster of abdominal obesity, atherogenic dyslipidaemia, hypertension and insulin resistance with or without hyperglycaemia associated with increased risk of coronary heart diseases. There may be a possible link between MS, central obesity and increased marke...

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Main Authors: Mohd Nawawi, Hapizah, Tengku Ismail, Tengku Saifudin, S. Krishnapilla, Ambigga Devi, Ramli, Anis Safura, T. Osman, Muhammad
Format: Research Reports
Language:English
Published: Research Management Institute (RMI) 2011
Subjects:
Biochemistry
Online Access:http://ir.uitm.edu.my/id/eprint/24817/
http://ir.uitm.edu.my/id/eprint/24817/1/LP_HAPIZAH%20MOHD%20NAWAWI%20RMI%2011_5.pdf
id uitm-24817
recordtype eprints
spelling uitm-248172019-07-19T02:24:02Z http://ir.uitm.edu.my/id/eprint/24817/ Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et. al.] Mohd Nawawi, Hapizah Tengku Ismail, Tengku Saifudin S. Krishnapilla, Ambigga Devi Ramli, Anis Safura T. Osman, Muhammad Biochemistry Background: Metabolic syndrome (MS) is a cluster of abdominal obesity, atherogenic dyslipidaemia, hypertension and insulin resistance with or without hyperglycaemia associated with increased risk of coronary heart diseases. There may be a possible link between MS, central obesity and increased markers of oxidative stress. The oxidative stress in central obesity and MS with different glycaemic status is still unclear. Objective: The aim of our study was to evaluate the oxidative stress in central obesity and MS subjects with different glycaemic status and subjects with central obesity without MS. Design: A total of 260 subjects (Mean±SD : 53±11, 66 Males) were randomly recruited and divided into 5 groups: central obesity without MS (OBXMS), MS with diabetes (MSDM), MS with impaired fasting glucose (MSIFG), MS with normoglycaemia (MSNG) and normal control (NC). In addition, MSDM, MSIFG and MSNG were grouped as all MS group with a total number of 156. The blood levels of oxidized low-density lipoprotein (oxLDL) and 8-Isoprostane were evaluated. Results: OBXMS group was not significantly different compared to NC group. MSDM group compared to NC group had higher 8-Isoprostane (pO.OOl). MSIFG group compared to NC group had higher oxLDL (p<0.05) and 8-Isoprostane (pO.OOl). MSNG group compared to NC group had higher 8-Isoprostane (pO.OOl). All MS group compared to NC group had higher oxLDL (p<0.05) and 8-Isoprostane (pO.OOl). All MS group compared to OBXMS group had higher 8-Isoprostane (pO.OOl). Conclusions: MS irrespective of glycaemic status has enhanced oxidative stress compared to controls. There is enhanced oxidative stress in central obesity especially in the presence of MS, suggesting high coronary risk of MS subjects. Research Management Institute (RMI) 2011 Research Reports NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/24817/1/LP_HAPIZAH%20MOHD%20NAWAWI%20RMI%2011_5.pdf Mohd Nawawi, Hapizah and Tengku Ismail, Tengku Saifudin and S. Krishnapilla, Ambigga Devi and Ramli, Anis Safura and T. Osman, Muhammad (2011) Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et. al.]. [Research Reports] (Unpublished)
repository_type Digital Repository
institution_category Local University
institution Universiti Teknologi MARA
building UiTM Institutional Repository
collection Online Access
language English
topic Biochemistry
spellingShingle Biochemistry
Mohd Nawawi, Hapizah
Tengku Ismail, Tengku Saifudin
S. Krishnapilla, Ambigga Devi
Ramli, Anis Safura
T. Osman, Muhammad
Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et. al.]
description Background: Metabolic syndrome (MS) is a cluster of abdominal obesity, atherogenic dyslipidaemia, hypertension and insulin resistance with or without hyperglycaemia associated with increased risk of coronary heart diseases. There may be a possible link between MS, central obesity and increased markers of oxidative stress. The oxidative stress in central obesity and MS with different glycaemic status is still unclear. Objective: The aim of our study was to evaluate the oxidative stress in central obesity and MS subjects with different glycaemic status and subjects with central obesity without MS. Design: A total of 260 subjects (Mean±SD : 53±11, 66 Males) were randomly recruited and divided into 5 groups: central obesity without MS (OBXMS), MS with diabetes (MSDM), MS with impaired fasting glucose (MSIFG), MS with normoglycaemia (MSNG) and normal control (NC). In addition, MSDM, MSIFG and MSNG were grouped as all MS group with a total number of 156. The blood levels of oxidized low-density lipoprotein (oxLDL) and 8-Isoprostane were evaluated. Results: OBXMS group was not significantly different compared to NC group. MSDM group compared to NC group had higher 8-Isoprostane (pO.OOl). MSIFG group compared to NC group had higher oxLDL (p<0.05) and 8-Isoprostane (pO.OOl). MSNG group compared to NC group had higher 8-Isoprostane (pO.OOl). All MS group compared to NC group had higher oxLDL (p<0.05) and 8-Isoprostane (pO.OOl). All MS group compared to OBXMS group had higher 8-Isoprostane (pO.OOl). Conclusions: MS irrespective of glycaemic status has enhanced oxidative stress compared to controls. There is enhanced oxidative stress in central obesity especially in the presence of MS, suggesting high coronary risk of MS subjects.
format Research Reports
author Mohd Nawawi, Hapizah
Tengku Ismail, Tengku Saifudin
S. Krishnapilla, Ambigga Devi
Ramli, Anis Safura
T. Osman, Muhammad
author_facet Mohd Nawawi, Hapizah
Tengku Ismail, Tengku Saifudin
S. Krishnapilla, Ambigga Devi
Ramli, Anis Safura
T. Osman, Muhammad
author_sort Mohd Nawawi, Hapizah
title Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et. al.]
title_short Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et. al.]
title_full Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et. al.]
title_fullStr Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et. al.]
title_full_unstemmed Oxidative stress in metabolic syndrome / Profesor Dr. Hapizah Mohd Nawawi … [et. al.]
title_sort oxidative stress in metabolic syndrome / profesor dr. hapizah mohd nawawi … [et. al.]
publisher Research Management Institute (RMI)
publishDate 2011
url http://ir.uitm.edu.my/id/eprint/24817/
http://ir.uitm.edu.my/id/eprint/24817/1/LP_HAPIZAH%20MOHD%20NAWAWI%20RMI%2011_5.pdf
first_indexed 2023-09-18T23:13:25Z
last_indexed 2023-09-18T23:13:25Z
_version_ 1777418953718497280

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