Rapid identification of quinone methide triterpenes using LCMS/MS approach / Dr. Humera Naz, Prof. Dr. JFF Weber and Dr. Hannis Fadzillah Mohsin

Medicinal plants have been used by mankind as a source of medicines since immemorial time. More than 35,000 plant species have been reported to be used in various human cultures around the world for medicinal purposes (Lewington & Network, 1993). Burkill (1966), in his extensive compilation of t...

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Main Authors:	Naz, Humera, JFF, Webe, Mohsin, Hannis Fadzillah
Format:	Research Reports
Language:	English
Published:	Research Management Institute (RMI) 2016
Subjects:	Medical botany (General) Medicinal plants (Culture only)
Online Access:	http://ir.uitm.edu.my/id/eprint/26240/ http://ir.uitm.edu.my/id/eprint/26240/1/LP_HUMERA%20NAZ%20RMI%2016_5.pdf

id	uitm-26240
recordtype	eprints
spelling	uitm-262402019-11-18T03:01:43Z http://ir.uitm.edu.my/id/eprint/26240/ Rapid identification of quinone methide triterpenes using LCMS/MS approach / Dr. Humera Naz, Prof. Dr. JFF Weber and Dr. Hannis Fadzillah Mohsin Naz, Humera JFF, Webe Mohsin, Hannis Fadzillah Medical botany (General) Medicinal plants (Culture only) Medicinal plants have been used by mankind as a source of medicines since immemorial time. More than 35,000 plant species have been reported to be used in various human cultures around the world for medicinal purposes (Lewington & Network, 1993). Burkill (1966), in his extensive compilation of the economic products of the Malay Peninsula, recorded around 1,300 plants that have been used in the local traditional medicine. The diverse flora of Malaysian forest offers a great abundance of chemical diversity of secondary metabolites and bioactive compounds such as alkaloids, flavonoids, steroids, xanthones and genetic variability that have great potential to serve the needs of modern medicine (Ahmad et al., 2003). The discovery of calanolide A and their derivatives from Calophyllum lanigerum (bintangor tree) with anti-HIV activities shows the potential of the forest in the drug discovery program and the importance of a well-planned research. Other Malaysian plants such as Eurycoma longifolia (tongkat AN), Centella asitatica (pegaga), Labisia pumila (kacip Fatimah), Elephantopus scaber (tapak Sulaiman) and Phyllanthus niruri (dukung anak) also showed good potential to be developed into useful drugs (Ahmad et ai, 2003). The plant extracts of the family Celastraceae have been used throughout South America and China as insect repellents and insecticides in traditional agriculture, and also as a remedy for stomach complaints, fever, rheumatoid arthritis and cancer (Spivey et ai, 2002). Quinone methides are secondary metabolites of the Celastraceae family. It is considered as chemotoxonomic indicators due to its major presence in Celastraceae family. Pristimerin, a quinonemethide triterpenoid derived from Celastraceae, has been proven by research to suppress tumor promotion, metastasis and angiogenesis (Kim et ai 2013). The bioactive compounds from L. javanicum is not thoroughly investigated. Therefore, this study is carried out in an attempt to characterise the phtochemical constituents and biological activities of this plant. Research Management Institute (RMI) 2016 Research Reports NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/26240/1/LP_HUMERA%20NAZ%20RMI%2016_5.pdf Naz, Humera and JFF, Webe and Mohsin, Hannis Fadzillah (2016) Rapid identification of quinone methide triterpenes using LCMS/MS approach / Dr. Humera Naz, Prof. Dr. JFF Weber and Dr. Hannis Fadzillah Mohsin. [Research Reports] (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Medical botany (General) Medicinal plants (Culture only)
spellingShingle	Medical botany (General) Medicinal plants (Culture only) Naz, Humera JFF, Webe Mohsin, Hannis Fadzillah Rapid identification of quinone methide triterpenes using LCMS/MS approach / Dr. Humera Naz, Prof. Dr. JFF Weber and Dr. Hannis Fadzillah Mohsin
description	Medicinal plants have been used by mankind as a source of medicines since immemorial time. More than 35,000 plant species have been reported to be used in various human cultures around the world for medicinal purposes (Lewington & Network, 1993). Burkill (1966), in his extensive compilation of the economic products of the Malay Peninsula, recorded around 1,300 plants that have been used in the local traditional medicine. The diverse flora of Malaysian forest offers a great abundance of chemical diversity of secondary metabolites and bioactive compounds such as alkaloids, flavonoids, steroids, xanthones and genetic variability that have great potential to serve the needs of modern medicine (Ahmad et al., 2003). The discovery of calanolide A and their derivatives from Calophyllum lanigerum (bintangor tree) with anti-HIV activities shows the potential of the forest in the drug discovery program and the importance of a well-planned research. Other Malaysian plants such as Eurycoma longifolia (tongkat AN), Centella asitatica (pegaga), Labisia pumila (kacip Fatimah), Elephantopus scaber (tapak Sulaiman) and Phyllanthus niruri (dukung anak) also showed good potential to be developed into useful drugs (Ahmad et ai, 2003). The plant extracts of the family Celastraceae have been used throughout South America and China as insect repellents and insecticides in traditional agriculture, and also as a remedy for stomach complaints, fever, rheumatoid arthritis and cancer (Spivey et ai, 2002). Quinone methides are secondary metabolites of the Celastraceae family. It is considered as chemotoxonomic indicators due to its major presence in Celastraceae family. Pristimerin, a quinonemethide triterpenoid derived from Celastraceae, has been proven by research to suppress tumor promotion, metastasis and angiogenesis (Kim et ai 2013). The bioactive compounds from L. javanicum is not thoroughly investigated. Therefore, this study is carried out in an attempt to characterise the phtochemical constituents and biological activities of this plant.
format	Research Reports
author	Naz, Humera JFF, Webe Mohsin, Hannis Fadzillah
author_facet	Naz, Humera JFF, Webe Mohsin, Hannis Fadzillah
author_sort	Naz, Humera
title	Rapid identification of quinone methide triterpenes using LCMS/MS approach / Dr. Humera Naz, Prof. Dr. JFF Weber and Dr. Hannis Fadzillah Mohsin
title_short	Rapid identification of quinone methide triterpenes using LCMS/MS approach / Dr. Humera Naz, Prof. Dr. JFF Weber and Dr. Hannis Fadzillah Mohsin
title_full	Rapid identification of quinone methide triterpenes using LCMS/MS approach / Dr. Humera Naz, Prof. Dr. JFF Weber and Dr. Hannis Fadzillah Mohsin
title_fullStr	Rapid identification of quinone methide triterpenes using LCMS/MS approach / Dr. Humera Naz, Prof. Dr. JFF Weber and Dr. Hannis Fadzillah Mohsin
title_full_unstemmed	Rapid identification of quinone methide triterpenes using LCMS/MS approach / Dr. Humera Naz, Prof. Dr. JFF Weber and Dr. Hannis Fadzillah Mohsin
title_sort	rapid identification of quinone methide triterpenes using lcms/ms approach / dr. humera naz, prof. dr. jff weber and dr. hannis fadzillah mohsin
publisher	Research Management Institute (RMI)
publishDate	2016
url	http://ir.uitm.edu.my/id/eprint/26240/ http://ir.uitm.edu.my/id/eprint/26240/1/LP_HUMERA%20NAZ%20RMI%2016_5.pdf
first_indexed	2023-09-18T23:16:28Z
last_indexed	2023-09-18T23:16:28Z
_version_	1777419145797697536

Rapid identification of quinone methide triterpenes using LCMS/MS approach / Dr. Humera Naz, Prof. Dr. JFF Weber and Dr. Hannis Fadzillah Mohsin

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