Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin

Colistin is an old antibiotic which use has been abandoned due to its nephrotoxicity. The rise of multidrug- resistance bacterial infections over the decade has led to the resurgence of colistin use. Since then, researches have taken interest into colistin including the incidence and predictors of c...

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Main Author:	Kamaludin, Ros Sakinah
Format:	Thesis
Language:	English
Published:	2016
Subjects:	Examination. Diagnosis. Including radiography
Online Access:	http://ir.uitm.edu.my/id/eprint/26257/ http://ir.uitm.edu.my/id/eprint/26257/1/TM_ROS%20SAKINAH%20KAMALUDIN%20PH%2016_5.pdf

id	uitm-26257
recordtype	eprints
spelling	uitm-262572019-10-23T08:40:27Z http://ir.uitm.edu.my/id/eprint/26257/ Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin Kamaludin, Ros Sakinah Examination. Diagnosis. Including radiography Colistin is an old antibiotic which use has been abandoned due to its nephrotoxicity. The rise of multidrug- resistance bacterial infections over the decade has led to the resurgence of colistin use. Since then, researches have taken interest into colistin including the incidence and predictors of colistin- associated acute kidney injury (AKI). Studies in other regions reported a wide range of incidence and multiple predictors of colistin- associated AKI. Since to date there is no such data from local healthcare setting, this retrospective cohort study aimed to determine the incidence and predictors of colistin- associated AKI in a Malaysian tertiary healthcare. 77 adult patients who received intravenous (IV) colistin in Hospital Raja Permaisuri Bainun in 2014 until September 2015 were included in the analysis. The incidence of colistin- associated AKI was 31.2% based on the Risk, Injury, Failure; Loss and End- stage Renal Disease (RIFLE) criteria employed. The predictors of colistin- associated AKI found were the length of hospital stay prior to colistin initiation (OR 1.044, 95% CI 1.004- 1.085; p= 0.03) and mechanical ventilation (OR 3.706, 95% CI 1.062- 12.940; p= 0.04). Study population profile and colistin regimen characteristics were comparable to those demonstrated by previous studies. Drug- event causality assessment using Naranjo Adverse Drug Reaction Scale revealed all of the AKI cases fell into ‘Possible’ category. The reported incidence validates the concern of colistin- associated AKI. Even though the predictors of such event varied, efforts to minimize colistin- associated AKI by controlling the risk factors are consistently warranted. 2016 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/26257/1/TM_ROS%20SAKINAH%20KAMALUDIN%20PH%2016_5.pdf Kamaludin, Ros Sakinah (2016) Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin. Masters thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Examination. Diagnosis. Including radiography
spellingShingle	Examination. Diagnosis. Including radiography Kamaludin, Ros Sakinah Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin
description	Colistin is an old antibiotic which use has been abandoned due to its nephrotoxicity. The rise of multidrug- resistance bacterial infections over the decade has led to the resurgence of colistin use. Since then, researches have taken interest into colistin including the incidence and predictors of colistin- associated acute kidney injury (AKI). Studies in other regions reported a wide range of incidence and multiple predictors of colistin- associated AKI. Since to date there is no such data from local healthcare setting, this retrospective cohort study aimed to determine the incidence and predictors of colistin- associated AKI in a Malaysian tertiary healthcare. 77 adult patients who received intravenous (IV) colistin in Hospital Raja Permaisuri Bainun in 2014 until September 2015 were included in the analysis. The incidence of colistin- associated AKI was 31.2% based on the Risk, Injury, Failure; Loss and End- stage Renal Disease (RIFLE) criteria employed. The predictors of colistin- associated AKI found were the length of hospital stay prior to colistin initiation (OR 1.044, 95% CI 1.004- 1.085; p= 0.03) and mechanical ventilation (OR 3.706, 95% CI 1.062- 12.940; p= 0.04). Study population profile and colistin regimen characteristics were comparable to those demonstrated by previous studies. Drug- event causality assessment using Naranjo Adverse Drug Reaction Scale revealed all of the AKI cases fell into ‘Possible’ category. The reported incidence validates the concern of colistin- associated AKI. Even though the predictors of such event varied, efforts to minimize colistin- associated AKI by controlling the risk factors are consistently warranted.
format	Thesis
author	Kamaludin, Ros Sakinah
author_facet	Kamaludin, Ros Sakinah
author_sort	Kamaludin, Ros Sakinah
title	Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin
title_short	Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin
title_full	Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin
title_fullStr	Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin
title_full_unstemmed	Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin
title_sort	incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / ros sakinah kamaludin
publishDate	2016
url	http://ir.uitm.edu.my/id/eprint/26257/ http://ir.uitm.edu.my/id/eprint/26257/1/TM_ROS%20SAKINAH%20KAMALUDIN%20PH%2016_5.pdf
first_indexed	2023-09-18T23:16:31Z
last_indexed	2023-09-18T23:16:31Z
_version_	1777419148327911424

Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin

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