Retinal ganglion cell protection against endothelin-1-induced injury by magnesium acetyl taurinate in rats / Dr. Sabrilhakim Sidek … [et al.]

Glaucoma, the leading cause of irreversible blindness, is characterized by apoptotic death of retinal ganglion cells (RGCs). Elevated levels of endothelin1 (ET1), a potent vasoconstrictor, have been detected in the eyes and plasma of glaucoma patients. Increased endothelin 1 causes retinal ischemia...

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Main Authors:	Agarwal, Renu, Nikolayevich lezhitsa, Igor, Mohd Ismail, Nafeeza, Krasilnikova, Anna, Mohd Arfuzir, Natasha Najwa
Format:	Research Reports
Language:	English
Published:	Research Management Institute (RMI) 2014
Subjects:	R Medicine (General)
Online Access:	http://ir.uitm.edu.my/id/eprint/26292/ http://ir.uitm.edu.my/id/eprint/26292/1/LP_SABRILHAKIM%20SIDEK%20RMI%2014_5.pdf

id	uitm-26292
recordtype	eprints
spelling	uitm-262922019-10-21T10:12:55Z http://ir.uitm.edu.my/id/eprint/26292/ Retinal ganglion cell protection against endothelin-1-induced injury by magnesium acetyl taurinate in rats / Dr. Sabrilhakim Sidek … [et al.] Agarwal, Renu Nikolayevich lezhitsa, Igor Mohd Ismail, Nafeeza Krasilnikova, Anna Mohd Arfuzir, Natasha Najwa R Medicine (General) Glaucoma, the leading cause of irreversible blindness, is characterized by apoptotic death of retinal ganglion cells (RGCs). Elevated levels of endothelin1 (ET1), a potent vasoconstrictor, have been detected in the eyes and plasma of glaucoma patients. Increased endothelin 1 causes retinal ischemia increased expression of nitric oxide synthase (NOS) isoforms and oxidative stress, which culminate into RGC apoptosis. Considering the vasodilating, and antioxidant properties of magnesium acetyltaurinate (MgAT) we hypothesized that it can prevent endothelin 1-induced vasospasm, improve retinal perfusion and reduce retinal oxidative stress by altering expression of 3 isoforms of NOS. Rats received single intravitreal injection of vehicle/ET1/ET1 with MgAT. Subsequently, histopathological examination of optic nerve were done to detect the extent of optic nerve damage. Immunochemical detection of NOS isoforms and estimation of NO and antioxidants was done in retina. It was observed that MgAT reduces retinal and optic nerve damage. This neuroprotective effect of MgAT was associated with reduced expression of NOS1 and 2, increased expression of NOS3 and reduced retinal oxidative stress. The results of this study were published in a Q1 journal and were presented in 2 national and 3 international conferences. One student has completed her Master's research work and has been promoted to PhD. Research Management Institute (RMI) 2014 Research Reports NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/26292/1/LP_SABRILHAKIM%20SIDEK%20RMI%2014_5.pdf Agarwal, Renu and Nikolayevich lezhitsa, Igor and Mohd Ismail, Nafeeza and Krasilnikova, Anna and Mohd Arfuzir, Natasha Najwa (2014) Retinal ganglion cell protection against endothelin-1-induced injury by magnesium acetyl taurinate in rats / Dr. Sabrilhakim Sidek … [et al.]. [Research Reports] (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Agarwal, Renu Nikolayevich lezhitsa, Igor Mohd Ismail, Nafeeza Krasilnikova, Anna Mohd Arfuzir, Natasha Najwa Retinal ganglion cell protection against endothelin-1-induced injury by magnesium acetyl taurinate in rats / Dr. Sabrilhakim Sidek … [et al.]
description	Glaucoma, the leading cause of irreversible blindness, is characterized by apoptotic death of retinal ganglion cells (RGCs). Elevated levels of endothelin1 (ET1), a potent vasoconstrictor, have been detected in the eyes and plasma of glaucoma patients. Increased endothelin 1 causes retinal ischemia increased expression of nitric oxide synthase (NOS) isoforms and oxidative stress, which culminate into RGC apoptosis. Considering the vasodilating, and antioxidant properties of magnesium acetyltaurinate (MgAT) we hypothesized that it can prevent endothelin 1-induced vasospasm, improve retinal perfusion and reduce retinal oxidative stress by altering expression of 3 isoforms of NOS. Rats received single intravitreal injection of vehicle/ET1/ET1 with MgAT. Subsequently, histopathological examination of optic nerve were done to detect the extent of optic nerve damage. Immunochemical detection of NOS isoforms and estimation of NO and antioxidants was done in retina. It was observed that MgAT reduces retinal and optic nerve damage. This neuroprotective effect of MgAT was associated with reduced expression of NOS1 and 2, increased expression of NOS3 and reduced retinal oxidative stress. The results of this study were published in a Q1 journal and were presented in 2 national and 3 international conferences. One student has completed her Master's research work and has been promoted to PhD.
format	Research Reports
author	Agarwal, Renu Nikolayevich lezhitsa, Igor Mohd Ismail, Nafeeza Krasilnikova, Anna Mohd Arfuzir, Natasha Najwa
author_facet	Agarwal, Renu Nikolayevich lezhitsa, Igor Mohd Ismail, Nafeeza Krasilnikova, Anna Mohd Arfuzir, Natasha Najwa
author_sort	Agarwal, Renu
title	Retinal ganglion cell protection against endothelin-1-induced injury by magnesium acetyl taurinate in rats / Dr. Sabrilhakim Sidek … [et al.]
title_short	Retinal ganglion cell protection against endothelin-1-induced injury by magnesium acetyl taurinate in rats / Dr. Sabrilhakim Sidek … [et al.]
title_full	Retinal ganglion cell protection against endothelin-1-induced injury by magnesium acetyl taurinate in rats / Dr. Sabrilhakim Sidek … [et al.]
title_fullStr	Retinal ganglion cell protection against endothelin-1-induced injury by magnesium acetyl taurinate in rats / Dr. Sabrilhakim Sidek … [et al.]
title_full_unstemmed	Retinal ganglion cell protection against endothelin-1-induced injury by magnesium acetyl taurinate in rats / Dr. Sabrilhakim Sidek … [et al.]
title_sort	retinal ganglion cell protection against endothelin-1-induced injury by magnesium acetyl taurinate in rats / dr. sabrilhakim sidek … [et al.]
publisher	Research Management Institute (RMI)
publishDate	2014
url	http://ir.uitm.edu.my/id/eprint/26292/ http://ir.uitm.edu.my/id/eprint/26292/1/LP_SABRILHAKIM%20SIDEK%20RMI%2014_5.pdf
first_indexed	2023-09-18T23:16:36Z
last_indexed	2023-09-18T23:16:36Z
_version_	1777419153444962304

Retinal ganglion cell protection against endothelin-1-induced injury by magnesium acetyl taurinate in rats / Dr. Sabrilhakim Sidek … [et al.]

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