Design of pectinate nanoparticles as oral insulin carrier / Mohammad Tarmizi Mohd Mokhtar

The formability and potential of zinc pectinate nanoparticles as an oral insulin carrier were investigated. Zinc pectinate nanoparticles were prepared through ionotropic gelation of pectin with zinc ions. When required, sodium chloride was added as channeling agent to induce rapid insulin release fr...

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Main Author:	Mohd Mokhtar, Mohammad Tarmizi
Format:	Thesis
Language:	English
Published:	2014
Subjects:	Oral and dental medicine. Pathology. Diseases
Online Access:	http://ir.uitm.edu.my/id/eprint/26744/ http://ir.uitm.edu.my/id/eprint/26744/1/TM_MOHAMMAD%20TARMIZI%20MOHD%20MOKHTAR%20PH%2014_5.pdf

id	uitm-26744
recordtype	eprints
spelling	uitm-267442019-12-04T02:30:49Z http://ir.uitm.edu.my/id/eprint/26744/ Design of pectinate nanoparticles as oral insulin carrier / Mohammad Tarmizi Mohd Mokhtar Mohd Mokhtar, Mohammad Tarmizi Oral and dental medicine. Pathology. Diseases The formability and potential of zinc pectinate nanoparticles as an oral insulin carrier were investigated. Zinc pectinate nanoparticles were prepared through ionotropic gelation of pectin with zinc ions. When required, sodium chloride was added as channeling agent to induce rapid insulin release from nanomatrices. The formed nanoparticles were subjected to in vitro size, morphology, zeta potential, drug content, drug association efficiency, drug release, drug-polymer and polymer-polymer interaction studies by means of zetasizer, scanning electron microscope, high performance liquid chromatography, dissolution tester, differential scanning calorimeter and fourier transform infra-red spectrometer, as well as in vivo blood glucose lowering investigation using streptozotocin-induced diabetic rats. Pectininsulin solution at pH 3 was ideal for use in nanoparticle preparation with Zn²⁺as crosslinking agent. The formed nanoparticles were able to encapsulate insulin substantially due to favourable electrostatic interaction between negatively charged pectin molecules with insulin and Zn²⁺ Unexpectedly, deionized water was found to exhibit a higher blood glucose lowering capacity than insulin solution, and to a lesser extent, blank and insulin loaded zinc pectinate nanoparticles. This was primarily due to interaction between water with insulin and/or excipients can lead to reduced water migration from gastrointestinal tract to systemic circulation. Formulation of insulin into polymeric nanoparticles may introduce complications in therapeutics related to water-nanoparticles interaction. 2014 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/26744/1/TM_MOHAMMAD%20TARMIZI%20MOHD%20MOKHTAR%20PH%2014_5.pdf Mohd Mokhtar, Mohammad Tarmizi (2014) Design of pectinate nanoparticles as oral insulin carrier / Mohammad Tarmizi Mohd Mokhtar. Masters thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Oral and dental medicine. Pathology. Diseases
spellingShingle	Oral and dental medicine. Pathology. Diseases Mohd Mokhtar, Mohammad Tarmizi Design of pectinate nanoparticles as oral insulin carrier / Mohammad Tarmizi Mohd Mokhtar
description	The formability and potential of zinc pectinate nanoparticles as an oral insulin carrier were investigated. Zinc pectinate nanoparticles were prepared through ionotropic gelation of pectin with zinc ions. When required, sodium chloride was added as channeling agent to induce rapid insulin release from nanomatrices. The formed nanoparticles were subjected to in vitro size, morphology, zeta potential, drug content, drug association efficiency, drug release, drug-polymer and polymer-polymer interaction studies by means of zetasizer, scanning electron microscope, high performance liquid chromatography, dissolution tester, differential scanning calorimeter and fourier transform infra-red spectrometer, as well as in vivo blood glucose lowering investigation using streptozotocin-induced diabetic rats. Pectininsulin solution at pH 3 was ideal for use in nanoparticle preparation with Zn²⁺as crosslinking agent. The formed nanoparticles were able to encapsulate insulin substantially due to favourable electrostatic interaction between negatively charged pectin molecules with insulin and Zn²⁺ Unexpectedly, deionized water was found to exhibit a higher blood glucose lowering capacity than insulin solution, and to a lesser extent, blank and insulin loaded zinc pectinate nanoparticles. This was primarily due to interaction between water with insulin and/or excipients can lead to reduced water migration from gastrointestinal tract to systemic circulation. Formulation of insulin into polymeric nanoparticles may introduce complications in therapeutics related to water-nanoparticles interaction.
format	Thesis
author	Mohd Mokhtar, Mohammad Tarmizi
author_facet	Mohd Mokhtar, Mohammad Tarmizi
author_sort	Mohd Mokhtar, Mohammad Tarmizi
title	Design of pectinate nanoparticles as oral insulin carrier / Mohammad Tarmizi Mohd Mokhtar
title_short	Design of pectinate nanoparticles as oral insulin carrier / Mohammad Tarmizi Mohd Mokhtar
title_full	Design of pectinate nanoparticles as oral insulin carrier / Mohammad Tarmizi Mohd Mokhtar
title_fullStr	Design of pectinate nanoparticles as oral insulin carrier / Mohammad Tarmizi Mohd Mokhtar
title_full_unstemmed	Design of pectinate nanoparticles as oral insulin carrier / Mohammad Tarmizi Mohd Mokhtar
title_sort	design of pectinate nanoparticles as oral insulin carrier / mohammad tarmizi mohd mokhtar
publishDate	2014
url	http://ir.uitm.edu.my/id/eprint/26744/ http://ir.uitm.edu.my/id/eprint/26744/1/TM_MOHAMMAD%20TARMIZI%20MOHD%20MOKHTAR%20PH%2014_5.pdf
first_indexed	2023-09-18T23:17:24Z
last_indexed	2023-09-18T23:17:24Z
_version_	1777419203694821376

Design of pectinate nanoparticles as oral insulin carrier / Mohammad Tarmizi Mohd Mokhtar

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