The prevalence and factors associated with undiagnosed dysglycaemia in established rheumatoid arthritis / Nur ‘Aini Eddy Warman

Background: Rheumatoid arthritis is a chronic inflammatory disease with an increased risk of diabetes and insulin resistance. Aims: To determine the prevalence of undiagnosed dysglycaemia and investigate the factors associated with it in patients with established RA. Methods: This was a cross-sectio...

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Main Author:	Eddy Warman, Nur ‘Aini
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Diseases of the musculoskeletal system
Online Access:	http://ir.uitm.edu.my/id/eprint/27254/ http://ir.uitm.edu.my/id/eprint/27254/1/TM_NUR%20%27AINI%20EDDY%20WARMAN%20MD%2017_5.pdf

id	uitm-27254
recordtype	eprints
spelling	uitm-272542020-01-14T04:31:58Z http://ir.uitm.edu.my/id/eprint/27254/ The prevalence and factors associated with undiagnosed dysglycaemia in established rheumatoid arthritis / Nur ‘Aini Eddy Warman Eddy Warman, Nur ‘Aini Diseases of the musculoskeletal system Background: Rheumatoid arthritis is a chronic inflammatory disease with an increased risk of diabetes and insulin resistance. Aims: To determine the prevalence of undiagnosed dysglycaemia and investigate the factors associated with it in patients with established RA. Methods: This was a cross-sectional study conducted in a rheumatology centre. One hundred fifty five consecutive patients were recruited. The inclusion criteria were patients with established RA, age > 30 years. Patients with diabetes or pre-diabetes were excluded. Demographic details, clinical data on RA and anthropometric measurements were obtained. Laboratory investigations performed included erythrocyte sedimentation rate, C-reactive protein, intracellular adhesion molecule (ICAM), lipid profile and plasma glucose. A 75goral glucose tolerance test was performed to determine dysglycaemia. Comparison of variables were done between two groups; dysglycaemia and normoglycaemia. Results: The mean age of patients was 57.2±8.1 years and majority (87.7%) were female. 35.5% (n=155) had dysglycaemia. Apart from ever smoker, there were no significant differences observed in age, gender and disease duration between the groups. Although RA disease activity and the average dose of corticosteroid used within six months were higher in dysglycaemia group, the differences were not statistically significant. Significant differences were observed in waist circumferences, weight, systolic and diastolic blood pressure, high-density lipoprotein, triglycerides and ICAM levels but after multivariate analysis, the predictors of dysglycaemia were ever smoker and high triglyceride level. Conclusion: One-third of our patients had dysglycaemia and they were heavier, larger waist circumference, higher blood pressure and LDL-c, and lower HDL-c. Predictors of dysglycaemia in established RA aged ≥30 years were ever smoker (OR 4.28) and high triglyceride level (OR 3.29). 2017 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/27254/1/TM_NUR%20%27AINI%20EDDY%20WARMAN%20MD%2017_5.pdf Eddy Warman, Nur ‘Aini (2017) The prevalence and factors associated with undiagnosed dysglycaemia in established rheumatoid arthritis / Nur ‘Aini Eddy Warman. Masters thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Diseases of the musculoskeletal system
spellingShingle	Diseases of the musculoskeletal system Eddy Warman, Nur ‘Aini The prevalence and factors associated with undiagnosed dysglycaemia in established rheumatoid arthritis / Nur ‘Aini Eddy Warman
description	Background: Rheumatoid arthritis is a chronic inflammatory disease with an increased risk of diabetes and insulin resistance. Aims: To determine the prevalence of undiagnosed dysglycaemia and investigate the factors associated with it in patients with established RA. Methods: This was a cross-sectional study conducted in a rheumatology centre. One hundred fifty five consecutive patients were recruited. The inclusion criteria were patients with established RA, age > 30 years. Patients with diabetes or pre-diabetes were excluded. Demographic details, clinical data on RA and anthropometric measurements were obtained. Laboratory investigations performed included erythrocyte sedimentation rate, C-reactive protein, intracellular adhesion molecule (ICAM), lipid profile and plasma glucose. A 75goral glucose tolerance test was performed to determine dysglycaemia. Comparison of variables were done between two groups; dysglycaemia and normoglycaemia. Results: The mean age of patients was 57.2±8.1 years and majority (87.7%) were female. 35.5% (n=155) had dysglycaemia. Apart from ever smoker, there were no significant differences observed in age, gender and disease duration between the groups. Although RA disease activity and the average dose of corticosteroid used within six months were higher in dysglycaemia group, the differences were not statistically significant. Significant differences were observed in waist circumferences, weight, systolic and diastolic blood pressure, high-density lipoprotein, triglycerides and ICAM levels but after multivariate analysis, the predictors of dysglycaemia were ever smoker and high triglyceride level. Conclusion: One-third of our patients had dysglycaemia and they were heavier, larger waist circumference, higher blood pressure and LDL-c, and lower HDL-c. Predictors of dysglycaemia in established RA aged ≥30 years were ever smoker (OR 4.28) and high triglyceride level (OR 3.29).
format	Thesis
author	Eddy Warman, Nur ‘Aini
author_facet	Eddy Warman, Nur ‘Aini
author_sort	Eddy Warman, Nur ‘Aini
title	The prevalence and factors associated with undiagnosed dysglycaemia in established rheumatoid arthritis / Nur ‘Aini Eddy Warman
title_short	The prevalence and factors associated with undiagnosed dysglycaemia in established rheumatoid arthritis / Nur ‘Aini Eddy Warman
title_full	The prevalence and factors associated with undiagnosed dysglycaemia in established rheumatoid arthritis / Nur ‘Aini Eddy Warman
title_fullStr	The prevalence and factors associated with undiagnosed dysglycaemia in established rheumatoid arthritis / Nur ‘Aini Eddy Warman
title_full_unstemmed	The prevalence and factors associated with undiagnosed dysglycaemia in established rheumatoid arthritis / Nur ‘Aini Eddy Warman
title_sort	prevalence and factors associated with undiagnosed dysglycaemia in established rheumatoid arthritis / nur ‘aini eddy warman
publishDate	2017
url	http://ir.uitm.edu.my/id/eprint/27254/ http://ir.uitm.edu.my/id/eprint/27254/1/TM_NUR%20%27AINI%20EDDY%20WARMAN%20MD%2017_5.pdf
first_indexed	2023-09-18T23:18:06Z
last_indexed	2023-09-18T23:18:06Z
_version_	1777419248664051712

The prevalence and factors associated with undiagnosed dysglycaemia in established rheumatoid arthritis / Nur ‘Aini Eddy Warman

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