Nanotoxicity assessment of iron oxide nanoparticles coated with perchloric acid and Sipeg in comparison to iodine as a radiographic contrast media / Nur Amirah Mohd Nor

Engineered nanoparticles have been extensively explored in various biomedical settings including nano particulate imaging agents due to its promising benefits to mankind. Iodine-intolerance patients have caused alarming concerns in searching new contrast media with lower toxicity effect. However, pr...

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Main Author:	Mohd Nor, Nur Amirah
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Neural networks (Computer science). Data processing Medical technology Medical physics. Medical radiology. Nuclear medicine
Online Access:	http://ir.uitm.edu.my/id/eprint/28058/ http://ir.uitm.edu.my/id/eprint/28058/1/TD_NUR%20AMIRAH%20MOHD%20NOR%20HS%2015_5.pdf

id	uitm-28058
recordtype	eprints
spelling	uitm-280582020-02-03T04:34:01Z http://ir.uitm.edu.my/id/eprint/28058/ Nanotoxicity assessment of iron oxide nanoparticles coated with perchloric acid and Sipeg in comparison to iodine as a radiographic contrast media / Nur Amirah Mohd Nor Mohd Nor, Nur Amirah Neural networks (Computer science). Data processing Medical technology Medical physics. Medical radiology. Nuclear medicine Engineered nanoparticles have been extensively explored in various biomedical settings including nano particulate imaging agents due to its promising benefits to mankind. Iodine-intolerance patients have caused alarming concerns in searching new contrast media with lower toxicity effect. However, proper potential mechanism of nanoparticles has yet to be fully established despite its early acceptance and emerging usage. By using animal model system, our aim is to assess acute nanotoxicity of 14 nm iron oxide nanoparticles (IONPs) coated with perchloric acid and silane-polyethylene glycol (SiPEG) in comparison to iodine. Eighteen Wistar Rats were used in order to explore the underlying toxicity of coated IONPs in liver tissues. .OH free radicals were elucidated by using reactive oxygen species (ROS) production assay and western blotting for the presence of p53 protein expression. The results revealed coated IONPs produced higher ROS level compared to iodine, however no statistical significant were observed. It can be hypothesized that higher amount of antioxidant has been produced by rats in iodine group in correlation to combat higher amount of ROS produced before assayed was conducted. Expressions of the p53 protein from the coated IONPs group were further observed. Expression of p53 protein suggested initiation of antioxidants production by the protein to ameliorate intracellular ROS production to further achieve normal redox balance in curtailing further damage. The outcomes highlighted that short-term administration of IONPs with functionalization surfaces are safe to be applied as radiographic contrast media. A STUDY OF THE MARKET REACTION TOWARDS BOARD OF 2015 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/28058/1/TD_NUR%20AMIRAH%20MOHD%20NOR%20HS%2015_5.pdf Mohd Nor, Nur Amirah (2015) Nanotoxicity assessment of iron oxide nanoparticles coated with perchloric acid and Sipeg in comparison to iodine as a radiographic contrast media / Nur Amirah Mohd Nor. Degree thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Neural networks (Computer science). Data processing Medical technology Medical physics. Medical radiology. Nuclear medicine
spellingShingle	Neural networks (Computer science). Data processing Medical technology Medical physics. Medical radiology. Nuclear medicine Mohd Nor, Nur Amirah Nanotoxicity assessment of iron oxide nanoparticles coated with perchloric acid and Sipeg in comparison to iodine as a radiographic contrast media / Nur Amirah Mohd Nor
description	Engineered nanoparticles have been extensively explored in various biomedical settings including nano particulate imaging agents due to its promising benefits to mankind. Iodine-intolerance patients have caused alarming concerns in searching new contrast media with lower toxicity effect. However, proper potential mechanism of nanoparticles has yet to be fully established despite its early acceptance and emerging usage. By using animal model system, our aim is to assess acute nanotoxicity of 14 nm iron oxide nanoparticles (IONPs) coated with perchloric acid and silane-polyethylene glycol (SiPEG) in comparison to iodine. Eighteen Wistar Rats were used in order to explore the underlying toxicity of coated IONPs in liver tissues. .OH free radicals were elucidated by using reactive oxygen species (ROS) production assay and western blotting for the presence of p53 protein expression. The results revealed coated IONPs produced higher ROS level compared to iodine, however no statistical significant were observed. It can be hypothesized that higher amount of antioxidant has been produced by rats in iodine group in correlation to combat higher amount of ROS produced before assayed was conducted. Expressions of the p53 protein from the coated IONPs group were further observed. Expression of p53 protein suggested initiation of antioxidants production by the protein to ameliorate intracellular ROS production to further achieve normal redox balance in curtailing further damage. The outcomes highlighted that short-term administration of IONPs with functionalization surfaces are safe to be applied as radiographic contrast media. A STUDY OF THE MARKET REACTION TOWARDS BOARD OF
format	Thesis
author	Mohd Nor, Nur Amirah
author_facet	Mohd Nor, Nur Amirah
author_sort	Mohd Nor, Nur Amirah
title	Nanotoxicity assessment of iron oxide nanoparticles coated with perchloric acid and Sipeg in comparison to iodine as a radiographic contrast media / Nur Amirah Mohd Nor
title_short	Nanotoxicity assessment of iron oxide nanoparticles coated with perchloric acid and Sipeg in comparison to iodine as a radiographic contrast media / Nur Amirah Mohd Nor
title_full	Nanotoxicity assessment of iron oxide nanoparticles coated with perchloric acid and Sipeg in comparison to iodine as a radiographic contrast media / Nur Amirah Mohd Nor
title_fullStr	Nanotoxicity assessment of iron oxide nanoparticles coated with perchloric acid and Sipeg in comparison to iodine as a radiographic contrast media / Nur Amirah Mohd Nor
title_full_unstemmed	Nanotoxicity assessment of iron oxide nanoparticles coated with perchloric acid and Sipeg in comparison to iodine as a radiographic contrast media / Nur Amirah Mohd Nor
title_sort	nanotoxicity assessment of iron oxide nanoparticles coated with perchloric acid and sipeg in comparison to iodine as a radiographic contrast media / nur amirah mohd nor
publishDate	2015
url	http://ir.uitm.edu.my/id/eprint/28058/ http://ir.uitm.edu.my/id/eprint/28058/1/TD_NUR%20AMIRAH%20MOHD%20NOR%20HS%2015_5.pdf
first_indexed	2023-09-18T23:19:31Z
last_indexed	2023-09-18T23:19:31Z
_version_	1777419337291792384

Nanotoxicity assessment of iron oxide nanoparticles coated with perchloric acid and Sipeg in comparison to iodine as a radiographic contrast media / Nur Amirah Mohd Nor

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