Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman
The behavior of rigid guluronic acid-rich (MG) and flexible mannuronic acid-rich (MC) alginate in controlling drug release responses of spray-dried microspheres against microwave was investigated using sodium diclofenac as model water-soluble drug. MC microspheres required a shorter period of micro...
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| Format: | Thesis |
| Language: | English |
| Published: |
2010
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| Online Access: | http://ir.uitm.edu.my/id/eprint/4833/ http://ir.uitm.edu.my/id/eprint/4833/1/TM_EKHA%20MARDZIAH%20RADMAN%20PH%2010_5.pdf |
| Summary: | The behavior of rigid guluronic acid-rich (MG) and flexible mannuronic acid-rich (MC) alginate in controlling drug release responses of spray-dried microspheres against
microwave was investigated using sodium diclofenac as model water-soluble drug. MC microspheres required a shorter period of microwave irradiation to reduce drug release
extent than MG microspheres. In response to microwave, the drug release profiles of 1:1 MG-MG microspheres resembled MC microspheres. The state of polymer-polymer and drug-polymer interaction via 0-H and/or N-H moiety of microspheres was affected by alginate chain flexibility under the influence of microwave. It then governed the drug
release responses of microspheres. |
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