Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman

The behavior of rigid guluronic acid-rich (MG) and flexible mannuronic acid-rich (MC) alginate in controlling drug release responses of spray-dried microspheres against microwave was investigated using sodium diclofenac as model water-soluble drug. MC microspheres required a shorter period of micro...

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Main Author:	Radman, Ekha Mardziah
Format:	Thesis
Language:	English
Published:	2010
Subjects:	RS Pharmacy and materia medica
Online Access:	http://ir.uitm.edu.my/id/eprint/4833/ http://ir.uitm.edu.my/id/eprint/4833/1/TM_EKHA%20MARDZIAH%20RADMAN%20PH%2010_5.pdf

id	uitm-4833
recordtype	eprints
spelling	uitm-48332018-08-30T04:30:37Z http://ir.uitm.edu.my/id/eprint/4833/ Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman Radman, Ekha Mardziah RS Pharmacy and materia medica The behavior of rigid guluronic acid-rich (MG) and flexible mannuronic acid-rich (MC) alginate in controlling drug release responses of spray-dried microspheres against microwave was investigated using sodium diclofenac as model water-soluble drug. MC microspheres required a shorter period of microwave irradiation to reduce drug release extent than MG microspheres. In response to microwave, the drug release profiles of 1:1 MG-MG microspheres resembled MC microspheres. The state of polymer-polymer and drug-polymer interaction via 0-H and/or N-H moiety of microspheres was affected by alginate chain flexibility under the influence of microwave. It then governed the drug release responses of microspheres. 2010 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/4833/1/TM_EKHA%20MARDZIAH%20RADMAN%20PH%2010_5.pdf Radman, Ekha Mardziah (2010) Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman. Masters thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Radman, Ekha Mardziah Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman
description	The behavior of rigid guluronic acid-rich (MG) and flexible mannuronic acid-rich (MC) alginate in controlling drug release responses of spray-dried microspheres against microwave was investigated using sodium diclofenac as model water-soluble drug. MC microspheres required a shorter period of microwave irradiation to reduce drug release extent than MG microspheres. In response to microwave, the drug release profiles of 1:1 MG-MG microspheres resembled MC microspheres. The state of polymer-polymer and drug-polymer interaction via 0-H and/or N-H moiety of microspheres was affected by alginate chain flexibility under the influence of microwave. It then governed the drug release responses of microspheres.
format	Thesis
author	Radman, Ekha Mardziah
author_facet	Radman, Ekha Mardziah
author_sort	Radman, Ekha Mardziah
title	Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman
title_short	Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman
title_full	Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman
title_fullStr	Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman
title_full_unstemmed	Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman
title_sort	effects of microwave on drug release responses of spray-dried alginate microspheres / ekha mardziah radman
publishDate	2010
url	http://ir.uitm.edu.my/id/eprint/4833/ http://ir.uitm.edu.my/id/eprint/4833/1/TM_EKHA%20MARDZIAH%20RADMAN%20PH%2010_5.pdf
first_indexed	2023-09-18T22:46:59Z
last_indexed	2023-09-18T22:46:59Z
_version_	1777417290423205888

Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman

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