pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira

Peptide-related drugs are usually unstable in the harsh gastrointestinal environment with poor absorption throughout the gut. The potential of anionic pH-sensitive nanoparticles to act as novel drug carriers for oral administration of such compounds was investigated using a peptidomimetic drug, cefo...

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Main Author:	Valente Pereira, Rosa Elizabeth
Format:	Thesis
Language:	English
Published:	2008
Subjects:	Drugs and their actions Pharmaceutical dosage forms Nanoparticles
Online Access:	http://ir.uitm.edu.my/id/eprint/5480/ http://ir.uitm.edu.my/id/eprint/5480/1/TP_ROSA%20ELIZABETH%20VALENTE%20PEREIRA%20PH%2008_5%201.pdf

id	uitm-5480
recordtype	eprints
spelling	uitm-54802016-11-26T06:51:00Z http://ir.uitm.edu.my/id/eprint/5480/ pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira Valente Pereira, Rosa Elizabeth Drugs and their actions Pharmaceutical dosage forms Nanoparticles Peptide-related drugs are usually unstable in the harsh gastrointestinal environment with poor absorption throughout the gut. The potential of anionic pH-sensitive nanoparticles to act as novel drug carriers for oral administration of such compounds was investigated using a peptidomimetic drug, cefotaxime sodium. Drug loaded nanoparticles were prepared using a pH-controlled nanoprecipitation method. Three types of nanoparticles were prepared using different grades of Eudragit polymer, namely L100, L100-55 and S100. The drug-loaded nanoparticles have a size of about 100 nm, low polydispersity, encapsulation efficiencies of more than 50%, drug entrapment and drug content between 4-5%. 2008 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/5480/1/TP_ROSA%20ELIZABETH%20VALENTE%20PEREIRA%20PH%2008_5%201.pdf Valente Pereira, Rosa Elizabeth (2008) pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira. PhD thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Drugs and their actions Pharmaceutical dosage forms Nanoparticles
spellingShingle	Drugs and their actions Pharmaceutical dosage forms Nanoparticles Valente Pereira, Rosa Elizabeth pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira
description	Peptide-related drugs are usually unstable in the harsh gastrointestinal environment with poor absorption throughout the gut. The potential of anionic pH-sensitive nanoparticles to act as novel drug carriers for oral administration of such compounds was investigated using a peptidomimetic drug, cefotaxime sodium. Drug loaded nanoparticles were prepared using a pH-controlled nanoprecipitation method. Three types of nanoparticles were prepared using different grades of Eudragit polymer, namely L100, L100-55 and S100. The drug-loaded nanoparticles have a size of about 100 nm, low polydispersity, encapsulation efficiencies of more than 50%, drug entrapment and drug content between 4-5%.
format	Thesis
author	Valente Pereira, Rosa Elizabeth
author_facet	Valente Pereira, Rosa Elizabeth
author_sort	Valente Pereira, Rosa Elizabeth
title	pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira
title_short	pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira
title_full	pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira
title_fullStr	pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira
title_full_unstemmed	pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira
title_sort	ph-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / rosa elizabeth valente pereira
publishDate	2008
url	http://ir.uitm.edu.my/id/eprint/5480/ http://ir.uitm.edu.my/id/eprint/5480/1/TP_ROSA%20ELIZABETH%20VALENTE%20PEREIRA%20PH%2008_5%201.pdf
first_indexed	2023-09-18T22:47:07Z
last_indexed	2023-09-18T22:47:07Z
_version_	1777417299151552512

pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira

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