Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman
Chalcones represent a group of compounds with interesting biological activities that are formed from an aldol condensation between a benzaldehyde and an acetophenone in the presence of NaOH as a catalyst. Although traditionally synthesized using aqueous sodium hydroxide in organic solvents, in th...
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uitm-7592016-05-26T07:58:10Z http://ir.uitm.edu.my/id/eprint/759/ Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman Osman, Muhamad Faridz QD Chemistry Chalcones represent a group of compounds with interesting biological activities that are formed from an aldol condensation between a benzaldehyde and an acetophenone in the presence of NaOH as a catalyst. Although traditionally synthesized using aqueous sodium hydroxide in organic solvents, in this study three different chalcones were synthesized using a solventless procedure. The solvent-free synthesis of three chalcones was carried out by grinding the benzaldehyde (3-nitro, 4-methoxy, 4-chloro) and 4- methoxyacetophenone in the presence of solid sodium hydroxide with a mortar and pestle. Chalcones were obtained in high yields (76-86%), high purity, and shorter reaction time (within five minutes). The results seemed to indicate the success of the solvent-free aldol synthesis which is simple, highly efficient and eco-friendly. For comparison, the three chalcones were also synthesized by the traditional aldol condensation catalyzed by aqueous sodium hydroxide in ethanol afforded lower yield (62-72%) and required longer reaction time (62-75 min). 2009 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/759/1/TD_MUHAMAD%20FARIDZ%20OSMAN_09_5%201.pdf Osman, Muhamad Faridz (2009) Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman. Degree thesis, Universiti Teknologi MARA. |
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QD Chemistry Osman, Muhamad Faridz Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman |
description |
Chalcones represent a group of compounds with interesting biological activities that are
formed from an aldol condensation between a benzaldehyde and an acetophenone in the
presence of NaOH as a catalyst. Although traditionally synthesized using aqueous sodium
hydroxide in organic solvents, in this study three different chalcones were synthesized
using a solventless procedure. The solvent-free synthesis of three chalcones was carried
out by grinding the benzaldehyde (3-nitro, 4-methoxy, 4-chloro) and 4-
methoxyacetophenone in the presence of solid sodium hydroxide with a mortar and
pestle. Chalcones were obtained in high yields (76-86%), high purity, and shorter
reaction time (within five minutes). The results seemed to indicate the success of the
solvent-free aldol synthesis which is simple, highly efficient and eco-friendly. For
comparison, the three chalcones were also synthesized by the traditional aldol
condensation catalyzed by aqueous sodium hydroxide in ethanol afforded lower yield
(62-72%) and required longer reaction time (62-75 min). |
format |
Thesis |
author |
Osman, Muhamad Faridz |
author_facet |
Osman, Muhamad Faridz |
author_sort |
Osman, Muhamad Faridz |
title |
Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman |
title_short |
Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman |
title_full |
Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman |
title_fullStr |
Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman |
title_full_unstemmed |
Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman |
title_sort |
solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (naoh) / muhamad faridz osman |
publishDate |
2009 |
url |
http://ir.uitm.edu.my/id/eprint/759/ http://ir.uitm.edu.my/id/eprint/759/1/TD_MUHAMAD%20FARIDZ%20OSMAN_09_5%201.pdf |
first_indexed |
2023-09-18T22:45:00Z |
last_indexed |
2023-09-18T22:45:00Z |
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1777417165295583232 |