Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman

Chalcones represent a group of compounds with interesting biological activities that are formed from an aldol condensation between a benzaldehyde and an acetophenone in the presence of NaOH as a catalyst. Although traditionally synthesized using aqueous sodium hydroxide in organic solvents, in th...

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Main Author:	Osman, Muhamad Faridz
Format:	Thesis
Language:	English
Published:	2009
Subjects:	QD Chemistry
Online Access:	http://ir.uitm.edu.my/id/eprint/759/ http://ir.uitm.edu.my/id/eprint/759/1/TD_MUHAMAD%20FARIDZ%20OSMAN_09_5%201.pdf

id	uitm-759
recordtype	eprints
spelling	uitm-7592016-05-26T07:58:10Z http://ir.uitm.edu.my/id/eprint/759/ Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman Osman, Muhamad Faridz QD Chemistry Chalcones represent a group of compounds with interesting biological activities that are formed from an aldol condensation between a benzaldehyde and an acetophenone in the presence of NaOH as a catalyst. Although traditionally synthesized using aqueous sodium hydroxide in organic solvents, in this study three different chalcones were synthesized using a solventless procedure. The solvent-free synthesis of three chalcones was carried out by grinding the benzaldehyde (3-nitro, 4-methoxy, 4-chloro) and 4- methoxyacetophenone in the presence of solid sodium hydroxide with a mortar and pestle. Chalcones were obtained in high yields (76-86%), high purity, and shorter reaction time (within five minutes). The results seemed to indicate the success of the solvent-free aldol synthesis which is simple, highly efficient and eco-friendly. For comparison, the three chalcones were also synthesized by the traditional aldol condensation catalyzed by aqueous sodium hydroxide in ethanol afforded lower yield (62-72%) and required longer reaction time (62-75 min). 2009 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/759/1/TD_MUHAMAD%20FARIDZ%20OSMAN_09_5%201.pdf Osman, Muhamad Faridz (2009) Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman. Degree thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Osman, Muhamad Faridz Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman
description	Chalcones represent a group of compounds with interesting biological activities that are formed from an aldol condensation between a benzaldehyde and an acetophenone in the presence of NaOH as a catalyst. Although traditionally synthesized using aqueous sodium hydroxide in organic solvents, in this study three different chalcones were synthesized using a solventless procedure. The solvent-free synthesis of three chalcones was carried out by grinding the benzaldehyde (3-nitro, 4-methoxy, 4-chloro) and 4- methoxyacetophenone in the presence of solid sodium hydroxide with a mortar and pestle. Chalcones were obtained in high yields (76-86%), high purity, and shorter reaction time (within five minutes). The results seemed to indicate the success of the solvent-free aldol synthesis which is simple, highly efficient and eco-friendly. For comparison, the three chalcones were also synthesized by the traditional aldol condensation catalyzed by aqueous sodium hydroxide in ethanol afforded lower yield (62-72%) and required longer reaction time (62-75 min).
format	Thesis
author	Osman, Muhamad Faridz
author_facet	Osman, Muhamad Faridz
author_sort	Osman, Muhamad Faridz
title	Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman
title_short	Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman
title_full	Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman
title_fullStr	Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman
title_full_unstemmed	Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman
title_sort	solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (naoh) / muhamad faridz osman
publishDate	2009
url	http://ir.uitm.edu.my/id/eprint/759/ http://ir.uitm.edu.my/id/eprint/759/1/TD_MUHAMAD%20FARIDZ%20OSMAN_09_5%201.pdf
first_indexed	2023-09-18T22:45:00Z
last_indexed	2023-09-18T22:45:00Z
_version_	1777417165295583232

Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman

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