Parathyroid hormone secreting metaplastic breast carcinoma: a case report of paraneoplastic syndrome

Paraneoplastic syndrome (PNS) is a distant neurological manifestation of an underlying tumour. Humoral hypercalcaemia of malignancy is a form of paraneoplastic syndrome where there is an increased in calcium levels. In this article we report a 48 year old lady, with no known medical illness and pres...

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Main Authors:	Al-Qaraghuli, Ahmed Mohammed Saliem, Nor Faezan AR, Rohaizak Muhammad
Format:	Article
Language:	English
Published:	Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre 2016
Online Access:	http://journalarticle.ukm.my/10245/ http://journalarticle.ukm.my/10245/ http://journalarticle.ukm.my/10245/1/12._ahmed_et_al..pdf

id	ukm-10245
recordtype	eprints
spelling	ukm-102452017-03-29T09:04:06Z http://journalarticle.ukm.my/10245/ Parathyroid hormone secreting metaplastic breast carcinoma: a case report of paraneoplastic syndrome Al-Qaraghuli, Ahmed Mohammed Saliem Nor Faezan AR, Rohaizak Muhammad, Paraneoplastic syndrome (PNS) is a distant neurological manifestation of an underlying tumour. Humoral hypercalcaemia of malignancy is a form of paraneoplastic syndrome where there is an increased in calcium levels. In this article we report a 48 year old lady, with no known medical illness and presented with symptomatic hypercalcaemia. She presented to our institution complaining of a fungating and ulcerating mass over the right breast, measuring 11 X 15 cm and associated with gradual paraxial body weakness. Further investigations revealed the lesion to be an invasive breast carcinoma with metaplastic features. Computed tomography (CT) scan showed a locally advanced breast carcinoma with right axillary node metastasis, without evidence of distant metastasis. Serum calcium, i-PTH together with SPECT has confirmed the patient to have a humoral hypercalcaemia malignancy with elevated ectopic parathyroid hormone level. Bone scan did not reveal any evidence of metastasis. High volume intake and loop diuretics were employed in the management of hypercalcaemia, which was eventually resolved following mastectomy with axillary clearance of the ipsilateral side. Currently she’s she is under oncologist’s follow up for further management. Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre 2016 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10245/1/12._ahmed_et_al..pdf Al-Qaraghuli, Ahmed Mohammed Saliem and Nor Faezan AR, and Rohaizak Muhammad, (2016) Parathyroid hormone secreting metaplastic breast carcinoma: a case report of paraneoplastic syndrome. Journal of Surgical Academia, 6 (2). pp. 46-49. ISSN 2231-7481 http://jsurgacad.com/toc
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Paraneoplastic syndrome (PNS) is a distant neurological manifestation of an underlying tumour. Humoral hypercalcaemia of malignancy is a form of paraneoplastic syndrome where there is an increased in calcium levels. In this article we report a 48 year old lady, with no known medical illness and presented with symptomatic hypercalcaemia. She presented to our institution complaining of a fungating and ulcerating mass over the right breast, measuring 11 X 15 cm and associated with gradual paraxial body weakness. Further investigations revealed the lesion to be an invasive breast carcinoma with metaplastic features. Computed tomography (CT) scan showed a locally advanced breast carcinoma with right axillary node metastasis, without evidence of distant metastasis. Serum calcium, i-PTH together with SPECT has confirmed the patient to have a humoral hypercalcaemia malignancy with elevated ectopic parathyroid hormone level. Bone scan did not reveal any evidence of metastasis. High volume intake and loop diuretics were employed in the management of hypercalcaemia, which was eventually resolved following mastectomy with axillary clearance of the ipsilateral side. Currently she’s she is under oncologist’s follow up for further management.
format	Article
author	Al-Qaraghuli, Ahmed Mohammed Saliem Nor Faezan AR, Rohaizak Muhammad,
spellingShingle	Al-Qaraghuli, Ahmed Mohammed Saliem Nor Faezan AR, Rohaizak Muhammad, Parathyroid hormone secreting metaplastic breast carcinoma: a case report of paraneoplastic syndrome
author_facet	Al-Qaraghuli, Ahmed Mohammed Saliem Nor Faezan AR, Rohaizak Muhammad,
author_sort	Al-Qaraghuli, Ahmed Mohammed Saliem
title	Parathyroid hormone secreting metaplastic breast carcinoma: a case report of paraneoplastic syndrome
title_short	Parathyroid hormone secreting metaplastic breast carcinoma: a case report of paraneoplastic syndrome
title_full	Parathyroid hormone secreting metaplastic breast carcinoma: a case report of paraneoplastic syndrome
title_fullStr	Parathyroid hormone secreting metaplastic breast carcinoma: a case report of paraneoplastic syndrome
title_full_unstemmed	Parathyroid hormone secreting metaplastic breast carcinoma: a case report of paraneoplastic syndrome
title_sort	parathyroid hormone secreting metaplastic breast carcinoma: a case report of paraneoplastic syndrome
publisher	Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre
publishDate	2016
url	http://journalarticle.ukm.my/10245/ http://journalarticle.ukm.my/10245/ http://journalarticle.ukm.my/10245/1/12._ahmed_et_al..pdf
first_indexed	2023-09-18T19:56:53Z
last_indexed	2023-09-18T19:56:53Z
_version_	1777406588255993856

Parathyroid hormone secreting metaplastic breast carcinoma: a case report of paraneoplastic syndrome

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