Evaluation of antihyperglycemic and antihyperlipidemic potential of Nelumbo nucifera seeds in diabetic rats

The present study was aimed at evaluating antihyperglycemic and antihyperlipidemic activity of nuciferin and norcoclaurine constituents of N. nucifera seeds, a well-known medicinal plant. The alloxan (100 mg/kg b.w) induced diabetic rats (200-250 g) were divided into seven groups (n = 6). Group I; n...

Full description

Bibliographic Details
Main Authors:	Shahnaz, Khan, Hidayatullah, Ali, Farman, Shah, Afzal, Kamran, Farhat, Jahan, Sarwat
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2016
Online Access:	http://journalarticle.ukm.my/10296/ http://journalarticle.ukm.my/10296/ http://journalarticle.ukm.my/10296/1/12%20Shahnaz.pdf

id	ukm-10296
recordtype	eprints
spelling	ukm-102962017-04-06T09:14:47Z http://journalarticle.ukm.my/10296/ Evaluation of antihyperglycemic and antihyperlipidemic potential of Nelumbo nucifera seeds in diabetic rats Shahnaz, Khan, Hidayatullah Ali, Farman Shah, Afzal Kamran, Farhat Jahan, Sarwat The present study was aimed at evaluating antihyperglycemic and antihyperlipidemic activity of nuciferin and norcoclaurine constituents of N. nucifera seeds, a well-known medicinal plant. The alloxan (100 mg/kg b.w) induced diabetic rats (200-250 g) were divided into seven groups (n = 6). Group I; normal control, Group II; diabetic control, Group III; standard, Group lV-VII were fed with methanolic crude extracts (100, 200 mg/kg), nuciferin and norcoclaurine (10 mg/kg b.w.), received for 15 days in dose dependent manner. The study included different parameters; examination of oral glucose, fasting blood glucose, serum lipid profile and checking for body weight changes. In oral glucose examination, within 60 and 80 min of treatment, extracts, nuciferin and norcoclaurine significantly reduced blood glucose (p<0.05) and restored body weight in diabetic rats. Alloxan- induced diabetic rats showed 30-50% reduction of blood glucose level (p<0.05) and recovered 5-20% body weight at day 15 after ingestion of crude extracts (100-200 mg/kg b.w.); and nuciferin and norcoclaurine (each at 10 mg/kg b.w.). It also recovered significantly elevated biochemical parameters such as triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), total cholesterol (TC), serum urea and creatinine. Our findings indicated that N. nucifera seeds possess significant antihyperglycemic and antihyperlipidemic activity in diabetic rats. Penerbit Universiti Kebangsaan Malaysia 2016-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10296/1/12%20Shahnaz.pdf Shahnaz, and Khan, Hidayatullah and Ali, Farman and Shah, Afzal and Kamran, Farhat and Jahan, Sarwat (2016) Evaluation of antihyperglycemic and antihyperlipidemic potential of Nelumbo nucifera seeds in diabetic rats. Sains Malaysiana, 45 (10). pp. 1517-1523. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol45num10_2016/contentsVol45num10_2016.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The present study was aimed at evaluating antihyperglycemic and antihyperlipidemic activity of nuciferin and norcoclaurine constituents of N. nucifera seeds, a well-known medicinal plant. The alloxan (100 mg/kg b.w) induced diabetic rats (200-250 g) were divided into seven groups (n = 6). Group I; normal control, Group II; diabetic control, Group III; standard, Group lV-VII were fed with methanolic crude extracts (100, 200 mg/kg), nuciferin and norcoclaurine (10 mg/kg b.w.), received for 15 days in dose dependent manner. The study included different parameters; examination of oral glucose, fasting blood glucose, serum lipid profile and checking for body weight changes. In oral glucose examination, within 60 and 80 min of treatment, extracts, nuciferin and norcoclaurine significantly reduced blood glucose (p<0.05) and restored body weight in diabetic rats. Alloxan- induced diabetic rats showed 30-50% reduction of blood glucose level (p<0.05) and recovered 5-20% body weight at day 15 after ingestion of crude extracts (100-200 mg/kg b.w.); and nuciferin and norcoclaurine (each at 10 mg/kg b.w.). It also recovered significantly elevated biochemical parameters such as triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), total cholesterol (TC), serum urea and creatinine. Our findings indicated that N. nucifera seeds possess significant antihyperglycemic and antihyperlipidemic activity in diabetic rats.
format	Article
author	Shahnaz, Khan, Hidayatullah Ali, Farman Shah, Afzal Kamran, Farhat Jahan, Sarwat
spellingShingle	Shahnaz, Khan, Hidayatullah Ali, Farman Shah, Afzal Kamran, Farhat Jahan, Sarwat Evaluation of antihyperglycemic and antihyperlipidemic potential of Nelumbo nucifera seeds in diabetic rats
author_facet	Shahnaz, Khan, Hidayatullah Ali, Farman Shah, Afzal Kamran, Farhat Jahan, Sarwat
author_sort	Shahnaz,
title	Evaluation of antihyperglycemic and antihyperlipidemic potential of Nelumbo nucifera seeds in diabetic rats
title_short	Evaluation of antihyperglycemic and antihyperlipidemic potential of Nelumbo nucifera seeds in diabetic rats
title_full	Evaluation of antihyperglycemic and antihyperlipidemic potential of Nelumbo nucifera seeds in diabetic rats
title_fullStr	Evaluation of antihyperglycemic and antihyperlipidemic potential of Nelumbo nucifera seeds in diabetic rats
title_full_unstemmed	Evaluation of antihyperglycemic and antihyperlipidemic potential of Nelumbo nucifera seeds in diabetic rats
title_sort	evaluation of antihyperglycemic and antihyperlipidemic potential of nelumbo nucifera seeds in diabetic rats
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2016
url	http://journalarticle.ukm.my/10296/ http://journalarticle.ukm.my/10296/ http://journalarticle.ukm.my/10296/1/12%20Shahnaz.pdf
first_indexed	2023-09-18T19:57:02Z
last_indexed	2023-09-18T19:57:02Z
_version_	1777406597825298432

Evaluation of antihyperglycemic and antihyperlipidemic potential of Nelumbo nucifera seeds in diabetic rats

Similar Items