Histological changes on testes of mice administered with different concentrations of Cosmos caudatus ethanolic extract

The histological changes of testes of mice were assessed after 28 days treatment with different concentrations of Cosmos caudatus ethanolic extract (50, 125, 500 and 1000 mg/kg). Testicular tissues were fixed in 10% formalin, embedded in paraffin wax and cut for histological study. The qualitative...

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Main Authors:	Marysia Julius Booh, Nooraain Hashim, Dzulsuhaimi Daud, Nur Hilwani Ismail
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2015
Online Access:	http://journalarticle.ukm.my/10341/ http://journalarticle.ukm.my/10341/ http://journalarticle.ukm.my/10341/1/44_1_07.pdf

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recordtype	eprints
spelling	ukm-103412017-04-21T09:49:03Z http://journalarticle.ukm.my/10341/ Histological changes on testes of mice administered with different concentrations of Cosmos caudatus ethanolic extract Marysia Julius Booh, Nooraain Hashim, Dzulsuhaimi Daud, Nur Hilwani Ismail, The histological changes of testes of mice were assessed after 28 days treatment with different concentrations of Cosmos caudatus ethanolic extract (50, 125, 500 and 1000 mg/kg). Testicular tissues were fixed in 10% formalin, embedded in paraffin wax and cut for histological study. The qualitative assessment of histological changes of the testes showed different degrees of thickness and density of seminiferous tubules as rated according to the following scales: 1, thin and low density of seminiferous tubules; 2, moderately thick and moderately dense seminiferous tubules; 3, thick and dense seminiferous tubules. Scale 3 was observed in testes of mice treated with 500 and 1000 mg/kg b wt., scale 2 in group treated with 50 mg/ kg b.wt. and scale 1 in group treated with 125 mg/kg b wt. of the extract. The total percentage of condensed seminiferous tubules (seminiferous tubules without lumen) is highest in the testes of mice from 500 mg/kg b wt. (52.5%) and the lowest from 125 mg/kg b wt. (26.3%). Both groups from 500 and 1000 mg/kg b wt. showed significant results (p<0.05) which the thickness of the seminiferous tubules increased as compared with the control group of mice. Hence, the higher concentration of C. caudatus gave better effects on spermatogenic activity of the testes of mice, as revealed by the density and thickness of the seminiferous tubules. Penerbit Universiti Kebangsaan Malaysia 2015-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10341/1/44_1_07.pdf Marysia Julius Booh, and Nooraain Hashim, and Dzulsuhaimi Daud, and Nur Hilwani Ismail, (2015) Histological changes on testes of mice administered with different concentrations of Cosmos caudatus ethanolic extract. Malaysian Applied Biology, 44 (3). pp. 33-36. ISSN 0126-8643 http://www.mabjournal.com/index.php?option=com_content&view=article&id=520&catid=59:current-view&Itemid=56
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The histological changes of testes of mice were assessed after 28 days treatment with different concentrations of Cosmos caudatus ethanolic extract (50, 125, 500 and 1000 mg/kg). Testicular tissues were fixed in 10% formalin, embedded in paraffin wax and cut for histological study. The qualitative assessment of histological changes of the testes showed different degrees of thickness and density of seminiferous tubules as rated according to the following scales: 1, thin and low density of seminiferous tubules; 2, moderately thick and moderately dense seminiferous tubules; 3, thick and dense seminiferous tubules. Scale 3 was observed in testes of mice treated with 500 and 1000 mg/kg b wt., scale 2 in group treated with 50 mg/ kg b.wt. and scale 1 in group treated with 125 mg/kg b wt. of the extract. The total percentage of condensed seminiferous tubules (seminiferous tubules without lumen) is highest in the testes of mice from 500 mg/kg b wt. (52.5%) and the lowest from 125 mg/kg b wt. (26.3%). Both groups from 500 and 1000 mg/kg b wt. showed significant results (p<0.05) which the thickness of the seminiferous tubules increased as compared with the control group of mice. Hence, the higher concentration of C. caudatus gave better effects on spermatogenic activity of the testes of mice, as revealed by the density and thickness of the seminiferous tubules.
format	Article
author	Marysia Julius Booh, Nooraain Hashim, Dzulsuhaimi Daud, Nur Hilwani Ismail,
spellingShingle	Marysia Julius Booh, Nooraain Hashim, Dzulsuhaimi Daud, Nur Hilwani Ismail, Histological changes on testes of mice administered with different concentrations of Cosmos caudatus ethanolic extract
author_facet	Marysia Julius Booh, Nooraain Hashim, Dzulsuhaimi Daud, Nur Hilwani Ismail,
author_sort	Marysia Julius Booh,
title	Histological changes on testes of mice administered with different concentrations of Cosmos caudatus ethanolic extract
title_short	Histological changes on testes of mice administered with different concentrations of Cosmos caudatus ethanolic extract
title_full	Histological changes on testes of mice administered with different concentrations of Cosmos caudatus ethanolic extract
title_fullStr	Histological changes on testes of mice administered with different concentrations of Cosmos caudatus ethanolic extract
title_full_unstemmed	Histological changes on testes of mice administered with different concentrations of Cosmos caudatus ethanolic extract
title_sort	histological changes on testes of mice administered with different concentrations of cosmos caudatus ethanolic extract
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2015
url	http://journalarticle.ukm.my/10341/ http://journalarticle.ukm.my/10341/ http://journalarticle.ukm.my/10341/1/44_1_07.pdf
first_indexed	2023-09-18T19:57:08Z
last_indexed	2023-09-18T19:57:08Z
_version_	1777406604427132928

Histological changes on testes of mice administered with different concentrations of Cosmos caudatus ethanolic extract

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