Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets

The efficacy of the combination vaccine of the individual C-terminal fragments of ApxIA, ApxIIA and ApxIIIA of Actinobacillus pleuropneumoniae (APP) was evaluated in piglets. Twenty piglets were divided equally into 2 groups (n=10). All piglets were intramuscularly primed at 4 week-of-age (0 week po...

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Main Authors:	Moon, Ja Yong Moon, Kang, Ji Young, Seo, Jeong-Woo, Kim, Won Kyong, Choi, Yeong Hwan, Choi, Min Soo, Hur, Jin
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2017
Online Access:	http://journalarticle.ukm.my/10673/ http://journalarticle.ukm.my/10673/ http://journalarticle.ukm.my/10673/1/05%20Ja%20Yong%20Moon.pdf

id	ukm-10673
recordtype	eprints
spelling	ukm-106732017-09-20T09:30:01Z http://journalarticle.ukm.my/10673/ Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets Moon, Ja Yong Moon Kang, Ji Young Seo, Jeong-Woo Kim, Won Kyong Choi, Yeong Hwan Choi, Min Soo Hur, Jin The efficacy of the combination vaccine of the individual C-terminal fragments of ApxIA, ApxIIA and ApxIIIA of Actinobacillus pleuropneumoniae (APP) was evaluated in piglets. Twenty piglets were divided equally into 2 groups (n=10). All piglets were intramuscularly primed at 4 week-of-age (0 week post prime inoculation (WPPI)) and were intramuscularly boosted at 6 week-of-age (2 WPPI). Group A piglets were inoculated with sterile PBS and group B piglets were inoculated with the combination vaccine. Concentrations of each of the C-terminal fragment-specific IgG as determined by ELISA were significantly higher in group B than in group A from 2 WPPI until the end of this study. Clinical signs were observed from only 10% of group B piglets after the challenge with the mixture of APP serotypes 1, 2 and 5 at 4 WPPI, while 50% of group A piglets were protected against APP infections. Overall, intramuscular inoculation with the vaccine candidate can efficiently protect piglets against APP infection. Penerbit Universiti Kebangsaan Malaysia 2017-02 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10673/1/05%20Ja%20Yong%20Moon.pdf Moon, Ja Yong Moon and Kang, Ji Young and Seo, Jeong-Woo and Kim, Won Kyong and Choi, Yeong Hwan and Choi, Min Soo and Hur, Jin (2017) Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets. Sains Malaysiana, 46 (2). pp. 217-221. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol46num2_2017/contentsVol46num2_2017.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The efficacy of the combination vaccine of the individual C-terminal fragments of ApxIA, ApxIIA and ApxIIIA of Actinobacillus pleuropneumoniae (APP) was evaluated in piglets. Twenty piglets were divided equally into 2 groups (n=10). All piglets were intramuscularly primed at 4 week-of-age (0 week post prime inoculation (WPPI)) and were intramuscularly boosted at 6 week-of-age (2 WPPI). Group A piglets were inoculated with sterile PBS and group B piglets were inoculated with the combination vaccine. Concentrations of each of the C-terminal fragment-specific IgG as determined by ELISA were significantly higher in group B than in group A from 2 WPPI until the end of this study. Clinical signs were observed from only 10% of group B piglets after the challenge with the mixture of APP serotypes 1, 2 and 5 at 4 WPPI, while 50% of group A piglets were protected against APP infections. Overall, intramuscular inoculation with the vaccine candidate can efficiently protect piglets against APP infection.
format	Article
author	Moon, Ja Yong Moon Kang, Ji Young Seo, Jeong-Woo Kim, Won Kyong Choi, Yeong Hwan Choi, Min Soo Hur, Jin
spellingShingle	Moon, Ja Yong Moon Kang, Ji Young Seo, Jeong-Woo Kim, Won Kyong Choi, Yeong Hwan Choi, Min Soo Hur, Jin Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets
author_facet	Moon, Ja Yong Moon Kang, Ji Young Seo, Jeong-Woo Kim, Won Kyong Choi, Yeong Hwan Choi, Min Soo Hur, Jin
author_sort	Moon, Ja Yong Moon
title	Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets
title_short	Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets
title_full	Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets
title_fullStr	Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets
title_full_unstemmed	Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets
title_sort	efficacy evaluation of combination vaccine of recombinant c-terminal fragments of apxia, apxiia and apxiiia in piglets
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2017
url	http://journalarticle.ukm.my/10673/ http://journalarticle.ukm.my/10673/ http://journalarticle.ukm.my/10673/1/05%20Ja%20Yong%20Moon.pdf
first_indexed	2023-09-18T19:58:05Z
last_indexed	2023-09-18T19:58:05Z
_version_	1777406663978909696

Efficacy evaluation of combination vaccine of recombinant C-terminal fragments of ApxIA, ApxIIA and ApxIIIA in piglets

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