Expression of p53 protein in premenopausal women as risk factors for breast cancer

Mutation is known to occur before the development of various types of cancers. Mutation in p53 gene can be found in human breast cancer. The aim of the present study was to determine the correlation between p53 protein expressions with women in premenopausal age. A total of 111 breast cancer tissues...

Full description

Bibliographic Details
Main Authors:	Rashidah S, Hairil Rashmizal Ar, Ho, SE, Wan Mazlina Md Saad
Format:	Article
Language:	English
Published:	Faculty of Medicine, Universiti Kebangsaan Malaysia 2016
Online Access:	http://journalarticle.ukm.my/10842/ http://journalarticle.ukm.my/10842/ http://journalarticle.ukm.my/10842/1/8_rashidah_et_al_pdf_47445.pdf

id	ukm-10842
recordtype	eprints
spelling	ukm-108422017-10-12T09:25:27Z http://journalarticle.ukm.my/10842/ Expression of p53 protein in premenopausal women as risk factors for breast cancer Rashidah S, Hairil Rashmizal Ar, Ho, SE Wan Mazlina Md Saad, Mutation is known to occur before the development of various types of cancers. Mutation in p53 gene can be found in human breast cancer. The aim of the present study was to determine the correlation between p53 protein expressions with women in premenopausal age. A total of 111 breast cancer tissues were examined for p53 protein expression by IHC. The results showed that majority (36.9%; n=41/111) who were more than 41 yrs, overexpressed positive p53 (+) protein category and 2.7% (n=3/111) aged 41 yrs and less, showed less positive p53 (+) protein category. However, the Fishers exact test, indicated that, there was no significant correlation between participant’s age group with p53 protein category (χ2 (1) = 0.78; p =0.52) and no correlation strength was indicated (Cramer’s V coefficient = 0.08; p =0.37), respectively. The risk estimate showed probability of p53 (+) protein being overexpressed in the age group < 41 yrs was 0.66 times less likely compared to the age group > 41 yrs. In conclusion, with or without overexpression of p53 protein, women above 41 yrs were found to have greater risk. Faculty of Medicine, Universiti Kebangsaan Malaysia 2016 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10842/1/8_rashidah_et_al_pdf_47445.pdf Rashidah S, and Hairil Rashmizal Ar, and Ho, SE and Wan Mazlina Md Saad, (2016) Expression of p53 protein in premenopausal women as risk factors for breast cancer. Medicine & Health, 11 (2). pp. 189-198. ISSN 1823-2140 http://www.medicineandhealthukm.com/toc/11/2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Mutation is known to occur before the development of various types of cancers. Mutation in p53 gene can be found in human breast cancer. The aim of the present study was to determine the correlation between p53 protein expressions with women in premenopausal age. A total of 111 breast cancer tissues were examined for p53 protein expression by IHC. The results showed that majority (36.9%; n=41/111) who were more than 41 yrs, overexpressed positive p53 (+) protein category and 2.7% (n=3/111) aged 41 yrs and less, showed less positive p53 (+) protein category. However, the Fishers exact test, indicated that, there was no significant correlation between participant’s age group with p53 protein category (χ2 (1) = 0.78; p =0.52) and no correlation strength was indicated (Cramer’s V coefficient = 0.08; p =0.37), respectively. The risk estimate showed probability of p53 (+) protein being overexpressed in the age group < 41 yrs was 0.66 times less likely compared to the age group > 41 yrs. In conclusion, with or without overexpression of p53 protein, women above 41 yrs were found to have greater risk.
format	Article
author	Rashidah S, Hairil Rashmizal Ar, Ho, SE Wan Mazlina Md Saad,
spellingShingle	Rashidah S, Hairil Rashmizal Ar, Ho, SE Wan Mazlina Md Saad, Expression of p53 protein in premenopausal women as risk factors for breast cancer
author_facet	Rashidah S, Hairil Rashmizal Ar, Ho, SE Wan Mazlina Md Saad,
author_sort	Rashidah S,
title	Expression of p53 protein in premenopausal women as risk factors for breast cancer
title_short	Expression of p53 protein in premenopausal women as risk factors for breast cancer
title_full	Expression of p53 protein in premenopausal women as risk factors for breast cancer
title_fullStr	Expression of p53 protein in premenopausal women as risk factors for breast cancer
title_full_unstemmed	Expression of p53 protein in premenopausal women as risk factors for breast cancer
title_sort	expression of p53 protein in premenopausal women as risk factors for breast cancer
publisher	Faculty of Medicine, Universiti Kebangsaan Malaysia
publishDate	2016
url	http://journalarticle.ukm.my/10842/ http://journalarticle.ukm.my/10842/ http://journalarticle.ukm.my/10842/1/8_rashidah_et_al_pdf_47445.pdf
first_indexed	2023-09-18T19:58:38Z
last_indexed	2023-09-18T19:58:38Z
_version_	1777406698944724992

Expression of p53 protein in premenopausal women as risk factors for breast cancer

Similar Items