Serum matrix metalloproteinase-3 predicts radiographic joint damage and functional disability in rheumatoid arthritis

The search for novel biomarkers has taken centre stage in the past decades of research in Rheumatoid Arthritis (RA). The purpose of the present study was to determine the correlation of serum matrix metalloproteinase-3 (MMP-3) with disease activity, joint damage and functional disability in patients...

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Main Authors:	Sakthiswary Rajalingham, Omimah KJN, Endom Ismail, Shaharir SS, Sridharan Radikha
Format:	Article
Language:	English
Published:	Faculty of Medicine, Universiti Kebangsaan Malaysia 2016
Online Access:	http://journalarticle.ukm.my/10844/ http://journalarticle.ukm.my/10844/ http://journalarticle.ukm.my/10844/1/10_sakthiswary_et_al_pdf_21616.pdf

id	ukm-10844
recordtype	eprints
spelling	ukm-108442017-10-12T09:29:24Z http://journalarticle.ukm.my/10844/ Serum matrix metalloproteinase-3 predicts radiographic joint damage and functional disability in rheumatoid arthritis Sakthiswary Rajalingham, Omimah KJN, Endom Ismail, Shaharir SS, Sridharan Radikha, The search for novel biomarkers has taken centre stage in the past decades of research in Rheumatoid Arthritis (RA). The purpose of the present study was to determine the correlation of serum matrix metalloproteinase-3 (MMP-3) with disease activity, joint damage and functional disability in patients with RA. We consecutively recruited RA patients who were under follow-up at the Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Information on the RA disease characteristics were obtained from the medical records and all RA patients were assessed for DAS28 (disease activity score based on 28 joints) and Stanford Health Assessment Questionnaire (HAQ) 8-item Disability Index (HAQ-DI). The hand radiographs of the RA patients were assessed for joint damage using the Modified Sharp Score (MSS). Serum MMP-3 levels from RA patients and healthy controls were measured using the ELISA method. We recruited a total of 77 RA patients and 18 healthy controls. The serum MMP-3 levels were significantly higher among the RA patients (p<0.05). There were significant correlations between the serum MMP-3 levels and MSS (r =0.327) and HAQ-DI (r=0.256), both p<0.05. The mean serum MMP levels in RA patients with radiographic joint erosions was significantly higher than in patients without erosions (p<0.05). Likewise, the subjects with significant functional impairment i.e HAQ-DI ≥1; had significantly higher mean MMP-3 levels compared to RA patients without significant disability (p<0.05). Using multivariate analysis, HAQ-DI remained the independent predictor of serum MMP-3 in RA patients. Serum MMP-3 is a potential biomarker and predictor of radiographic joint damage and functional disability in RA. Faculty of Medicine, Universiti Kebangsaan Malaysia 2016 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10844/1/10_sakthiswary_et_al_pdf_21616.pdf Sakthiswary Rajalingham, and Omimah KJN, and Endom Ismail, and Shaharir SS, and Sridharan Radikha, (2016) Serum matrix metalloproteinase-3 predicts radiographic joint damage and functional disability in rheumatoid arthritis. Medicine & Health, 11 (2). pp. 209-217. ISSN 1823-2140 http://www.medicineandhealthukm.com/toc/11/2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The search for novel biomarkers has taken centre stage in the past decades of research in Rheumatoid Arthritis (RA). The purpose of the present study was to determine the correlation of serum matrix metalloproteinase-3 (MMP-3) with disease activity, joint damage and functional disability in patients with RA. We consecutively recruited RA patients who were under follow-up at the Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Information on the RA disease characteristics were obtained from the medical records and all RA patients were assessed for DAS28 (disease activity score based on 28 joints) and Stanford Health Assessment Questionnaire (HAQ) 8-item Disability Index (HAQ-DI). The hand radiographs of the RA patients were assessed for joint damage using the Modified Sharp Score (MSS). Serum MMP-3 levels from RA patients and healthy controls were measured using the ELISA method. We recruited a total of 77 RA patients and 18 healthy controls. The serum MMP-3 levels were significantly higher among the RA patients (p<0.05). There were significant correlations between the serum MMP-3 levels and MSS (r =0.327) and HAQ-DI (r=0.256), both p<0.05. The mean serum MMP levels in RA patients with radiographic joint erosions was significantly higher than in patients without erosions (p<0.05). Likewise, the subjects with significant functional impairment i.e HAQ-DI ≥1; had significantly higher mean MMP-3 levels compared to RA patients without significant disability (p<0.05). Using multivariate analysis, HAQ-DI remained the independent predictor of serum MMP-3 in RA patients. Serum MMP-3 is a potential biomarker and predictor of radiographic joint damage and functional disability in RA.
format	Article
author	Sakthiswary Rajalingham, Omimah KJN, Endom Ismail, Shaharir SS, Sridharan Radikha,
spellingShingle	Sakthiswary Rajalingham, Omimah KJN, Endom Ismail, Shaharir SS, Sridharan Radikha, Serum matrix metalloproteinase-3 predicts radiographic joint damage and functional disability in rheumatoid arthritis
author_facet	Sakthiswary Rajalingham, Omimah KJN, Endom Ismail, Shaharir SS, Sridharan Radikha,
author_sort	Sakthiswary Rajalingham,
title	Serum matrix metalloproteinase-3 predicts radiographic joint damage and functional disability in rheumatoid arthritis
title_short	Serum matrix metalloproteinase-3 predicts radiographic joint damage and functional disability in rheumatoid arthritis
title_full	Serum matrix metalloproteinase-3 predicts radiographic joint damage and functional disability in rheumatoid arthritis
title_fullStr	Serum matrix metalloproteinase-3 predicts radiographic joint damage and functional disability in rheumatoid arthritis
title_full_unstemmed	Serum matrix metalloproteinase-3 predicts radiographic joint damage and functional disability in rheumatoid arthritis
title_sort	serum matrix metalloproteinase-3 predicts radiographic joint damage and functional disability in rheumatoid arthritis
publisher	Faculty of Medicine, Universiti Kebangsaan Malaysia
publishDate	2016
url	http://journalarticle.ukm.my/10844/ http://journalarticle.ukm.my/10844/ http://journalarticle.ukm.my/10844/1/10_sakthiswary_et_al_pdf_21616.pdf
first_indexed	2023-09-18T19:58:38Z
last_indexed	2023-09-18T19:58:38Z
_version_	1777406699243569152

Serum matrix metalloproteinase-3 predicts radiographic joint damage and functional disability in rheumatoid arthritis

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