Patterns of polypoidal choroidal vasculopathy among a multiracial population in a Malaysian hospital

Polypoidal choroidal vasculopathy (PCV) is a retinal disorder characterized by aneurismal polypoidal lesions in choroidal vasculature. PCV appears to preferentially affect pigmented individuals and is considerably high among Asians. Most reports on patterns of PCV around Asia are based on a homogeno...

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Main Authors:	Nazima SA, Hanisah AH, Rona Asnida Nasaruddin, Wong, HS, Amin Ahem, Bastion, Mae-Lynn Catherine, Mushawiahti Mustapha, Hazlita Mohd Isa
Format:	Article
Language:	English
Published:	Faculty of Medicine, Universiti Kebangsaan Malaysia 2016
Online Access:	http://journalarticle.ukm.my/10847/ http://journalarticle.ukm.my/10847/ http://journalarticle.ukm.my/10847/1/13_nazima_et_al_pdf_14594.pdf

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recordtype	eprints
spelling	ukm-108472017-10-12T09:34:18Z http://journalarticle.ukm.my/10847/ Patterns of polypoidal choroidal vasculopathy among a multiracial population in a Malaysian hospital Nazima SA, Hanisah AH, Rona Asnida Nasaruddin, Wong, HS Amin Ahem, Bastion, Mae-Lynn Catherine Mushawiahti Mustapha, Hazlita Mohd Isa, Polypoidal choroidal vasculopathy (PCV) is a retinal disorder characterized by aneurismal polypoidal lesions in choroidal vasculature. PCV appears to preferentially affect pigmented individuals and is considerably high among Asians. Most reports on patterns of PCV around Asia are based on a homogenous race (e.g. Chinese, Japanese) and very few descriptions from a multiracial population like those seen in Malaysia. The present study aimed to describe the demographic features, clinical and investigative characteristics of PCV in a multiracial group at Universiti Kebangsaaan Malaysia Medical Centre (UKMMC). Ninety one eyes of 86 PCV patients, comprising of Chinese (65.1%), Malays (31.4%), Indians (2.3%) and Eurasian (1.2%) were retrospectively reviewed. All underwent complete ophthalmic examination and investigations. Mean patient age was 70.4 years with a male preponderance (59.3%), and mostly unilateral presentation (94.1%). The logMAR mean presenting visual acuity was 0.78 ± 0.64. Polypoidal vascular lesions were located generally within the macula area (86.8%), manifesting mainly as submacular hemorrhage (59.3%). Interestingly a number of eyes (43.9%) had associated drusen. Optical coherence tomography largely demonstrated exudative changes (75.9%) and almost all patients (97.7%) had loss of external limiting membrane (ELM) and IS/OS interface. On indocyanine green angiography, majority of eyes had multiple polyps (82.4%) with ‘cluster’ (58.2%) being the commonest configuration. In conclusion, although the patterns of PCV in UKMMC were mainly similar to other Asian patients, a number of our patients had associated drusen. This indicates that PCV in our population could be a variant of neovascular age related macular degeneration and not solely idiopathic in nature. Faculty of Medicine, Universiti Kebangsaan Malaysia 2016 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10847/1/13_nazima_et_al_pdf_14594.pdf Nazima SA, and Hanisah AH, and Rona Asnida Nasaruddin, and Wong, HS and Amin Ahem, and Bastion, Mae-Lynn Catherine and Mushawiahti Mustapha, and Hazlita Mohd Isa, (2016) Patterns of polypoidal choroidal vasculopathy among a multiracial population in a Malaysian hospital. Medicine & Health, 11 (2). pp. 245-256. ISSN 1823-2140 http://www.medicineandhealthukm.com/toc/11/2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Polypoidal choroidal vasculopathy (PCV) is a retinal disorder characterized by aneurismal polypoidal lesions in choroidal vasculature. PCV appears to preferentially affect pigmented individuals and is considerably high among Asians. Most reports on patterns of PCV around Asia are based on a homogenous race (e.g. Chinese, Japanese) and very few descriptions from a multiracial population like those seen in Malaysia. The present study aimed to describe the demographic features, clinical and investigative characteristics of PCV in a multiracial group at Universiti Kebangsaaan Malaysia Medical Centre (UKMMC). Ninety one eyes of 86 PCV patients, comprising of Chinese (65.1%), Malays (31.4%), Indians (2.3%) and Eurasian (1.2%) were retrospectively reviewed. All underwent complete ophthalmic examination and investigations. Mean patient age was 70.4 years with a male preponderance (59.3%), and mostly unilateral presentation (94.1%). The logMAR mean presenting visual acuity was 0.78 ± 0.64. Polypoidal vascular lesions were located generally within the macula area (86.8%), manifesting mainly as submacular hemorrhage (59.3%). Interestingly a number of eyes (43.9%) had associated drusen. Optical coherence tomography largely demonstrated exudative changes (75.9%) and almost all patients (97.7%) had loss of external limiting membrane (ELM) and IS/OS interface. On indocyanine green angiography, majority of eyes had multiple polyps (82.4%) with ‘cluster’ (58.2%) being the commonest configuration. In conclusion, although the patterns of PCV in UKMMC were mainly similar to other Asian patients, a number of our patients had associated drusen. This indicates that PCV in our population could be a variant of neovascular age related macular degeneration and not solely idiopathic in nature.
format	Article
author	Nazima SA, Hanisah AH, Rona Asnida Nasaruddin, Wong, HS Amin Ahem, Bastion, Mae-Lynn Catherine Mushawiahti Mustapha, Hazlita Mohd Isa,
spellingShingle	Nazima SA, Hanisah AH, Rona Asnida Nasaruddin, Wong, HS Amin Ahem, Bastion, Mae-Lynn Catherine Mushawiahti Mustapha, Hazlita Mohd Isa, Patterns of polypoidal choroidal vasculopathy among a multiracial population in a Malaysian hospital
author_facet	Nazima SA, Hanisah AH, Rona Asnida Nasaruddin, Wong, HS Amin Ahem, Bastion, Mae-Lynn Catherine Mushawiahti Mustapha, Hazlita Mohd Isa,
author_sort	Nazima SA,
title	Patterns of polypoidal choroidal vasculopathy among a multiracial population in a Malaysian hospital
title_short	Patterns of polypoidal choroidal vasculopathy among a multiracial population in a Malaysian hospital
title_full	Patterns of polypoidal choroidal vasculopathy among a multiracial population in a Malaysian hospital
title_fullStr	Patterns of polypoidal choroidal vasculopathy among a multiracial population in a Malaysian hospital
title_full_unstemmed	Patterns of polypoidal choroidal vasculopathy among a multiracial population in a Malaysian hospital
title_sort	patterns of polypoidal choroidal vasculopathy among a multiracial population in a malaysian hospital
publisher	Faculty of Medicine, Universiti Kebangsaan Malaysia
publishDate	2016
url	http://journalarticle.ukm.my/10847/ http://journalarticle.ukm.my/10847/ http://journalarticle.ukm.my/10847/1/13_nazima_et_al_pdf_14594.pdf
first_indexed	2023-09-18T19:58:39Z
last_indexed	2023-09-18T19:58:39Z
_version_	1777406699673485312

Patterns of polypoidal choroidal vasculopathy among a multiracial population in a Malaysian hospital

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