Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients

The purpose of this study was to characterize, differentiate and correlate visual field and brain activation in visual cortex for normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) participants using Standard Automated Perimetry (SAP) and functional Magnetic Resonance Imaging (fMRI...

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Main Authors:	Nurul Hanim Nasaruddin, Ahmad Nazlim Yusoff, Sharanjeet Kaur
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2017
Online Access:	http://journalarticle.ukm.my/11455/ http://journalarticle.ukm.my/11455/ http://journalarticle.ukm.my/11455/1/16741-47126-1-SM.pdf

id	ukm-11455
recordtype	eprints
spelling	ukm-114552018-03-16T01:05:58Z http://journalarticle.ukm.my/11455/ Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients Nurul Hanim Nasaruddin, Ahmad Nazlim Yusoff, Sharanjeet Kaur, The purpose of this study was to characterize, differentiate and correlate visual field and brain activation in visual cortex for normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) participants using Standard Automated Perimetry (SAP) and functional Magnetic Resonance Imaging (fMRI) respectively. The fMRI scans and SAP test were both carried out in Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM). Two types of black-and-white checkerboard pattern were displayed to the participants during the fMRI scans. The fMRI data were analyzed using WFU pickatlas toolbox targeting visual cortex area. The results showed that there was no significant difference in number of activated voxel between the three groups in visual cortex (BA 17, 18 and 19) while viewing all the given stimuli (p > 0.05). The pattern standard deviation (PSD) of SAP for visual field also revealed no significant differences (p > 0.05) in all groups of participants. However, negative correlation between PSD and fMRI activation was observed. The PSD values increased with a decrease in fMRI activation. With reference to visual field analysis, the results suggest that glaucomatous neuropathy of POAG patients has led to a gradual decrease in visual cortex activation and a gradual increase in PSD. Penerbit Universiti Kebangsaan Malaysia 2017 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11455/1/16741-47126-1-SM.pdf Nurul Hanim Nasaruddin, and Ahmad Nazlim Yusoff, and Sharanjeet Kaur, (2017) Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients. Jurnal Sains Kesihatan Malaysia, 15 (1). pp. 27-32. ISSN 1675-8161 http://ejournal.ukm.my/jskm/issue/view/635
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The purpose of this study was to characterize, differentiate and correlate visual field and brain activation in visual cortex for normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) participants using Standard Automated Perimetry (SAP) and functional Magnetic Resonance Imaging (fMRI) respectively. The fMRI scans and SAP test were both carried out in Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM). Two types of black-and-white checkerboard pattern were displayed to the participants during the fMRI scans. The fMRI data were analyzed using WFU pickatlas toolbox targeting visual cortex area. The results showed that there was no significant difference in number of activated voxel between the three groups in visual cortex (BA 17, 18 and 19) while viewing all the given stimuli (p > 0.05). The pattern standard deviation (PSD) of SAP for visual field also revealed no significant differences (p > 0.05) in all groups of participants. However, negative correlation between PSD and fMRI activation was observed. The PSD values increased with a decrease in fMRI activation. With reference to visual field analysis, the results suggest that glaucomatous neuropathy of POAG patients has led to a gradual decrease in visual cortex activation and a gradual increase in PSD.
format	Article
author	Nurul Hanim Nasaruddin, Ahmad Nazlim Yusoff, Sharanjeet Kaur,
spellingShingle	Nurul Hanim Nasaruddin, Ahmad Nazlim Yusoff, Sharanjeet Kaur, Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients
author_facet	Nurul Hanim Nasaruddin, Ahmad Nazlim Yusoff, Sharanjeet Kaur,
author_sort	Nurul Hanim Nasaruddin,
title	Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients
title_short	Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients
title_full	Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients
title_fullStr	Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients
title_full_unstemmed	Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients
title_sort	functional mri characteristics in visual cortex (ba 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (gs) and primary open angle glaucoma (poag) patients
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2017
url	http://journalarticle.ukm.my/11455/ http://journalarticle.ukm.my/11455/ http://journalarticle.ukm.my/11455/1/16741-47126-1-SM.pdf
first_indexed	2023-09-18T20:00:24Z
last_indexed	2023-09-18T20:00:24Z
_version_	1777406809651281920

Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients

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