Cytotoxicity and oxidative stress evaluation of Alginate/Cockle Shell powder nanobiocomposite bone scaffold on osteoblast

Biocompatibility and growth of osteoblast on bone scaffolds play an important role towards their therapeutic application. The presence of oxidative stress generated by bone scaffolds highly influences osteoblast growth and its functional performance. In this study in-vitro interaction of developed A...

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Main Authors:	Nurnadiah Ahmad, B. Hemabarathy Bharatham, Zariyantey Abdul Hamid, Nor Zulaikha Zulkipli
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2017
Online Access:	http://journalarticle.ukm.my/11463/ http://journalarticle.ukm.my/11463/ http://journalarticle.ukm.my/11463/1/16753-47156-1-SM.pdf

id	ukm-11463
recordtype	eprints
spelling	ukm-114632018-03-16T01:03:33Z http://journalarticle.ukm.my/11463/ Cytotoxicity and oxidative stress evaluation of Alginate/Cockle Shell powder nanobiocomposite bone scaffold on osteoblast Nurnadiah Ahmad, B. Hemabarathy Bharatham, Zariyantey Abdul Hamid, Nor Zulaikha Zulkipli, Biocompatibility and growth of osteoblast on bone scaffolds play an important role towards their therapeutic application. The presence of oxidative stress generated by bone scaffolds highly influences osteoblast growth and its functional performance. In this study in-vitro interaction of developed Alginate/Cockle Shell powder nanobiocomposite bone scaffold on osteoblast with regards to cytotoxicity and oxidative stress are evaluated. Cytotoxicity studies using MTT assays revealed a significant increase in viability of cultured osteoblast in the presences of the scaffold extracts. The growth of osteoblast on the scaffold were not deterred with the presence of any major oxidative stress factors as determined through oxidative stress profile studies using SOD, GSH and ROS assays. The nanobiocomposite scaffold evaluated in this study shows promising use in regards to facilitating osteoblast proliferation, growth and viability. Penerbit Universiti Kebangsaan Malaysia 2017 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11463/1/16753-47156-1-SM.pdf Nurnadiah Ahmad, and B. Hemabarathy Bharatham, and Zariyantey Abdul Hamid, and Nor Zulaikha Zulkipli, (2017) Cytotoxicity and oxidative stress evaluation of Alginate/Cockle Shell powder nanobiocomposite bone scaffold on osteoblast. Jurnal Sains Kesihatan Malaysia, 15 (1). pp. 97-103. ISSN 1675-8161 http://ejournal.ukm.my/jskm/issue/view/635
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Biocompatibility and growth of osteoblast on bone scaffolds play an important role towards their therapeutic application. The presence of oxidative stress generated by bone scaffolds highly influences osteoblast growth and its functional performance. In this study in-vitro interaction of developed Alginate/Cockle Shell powder nanobiocomposite bone scaffold on osteoblast with regards to cytotoxicity and oxidative stress are evaluated. Cytotoxicity studies using MTT assays revealed a significant increase in viability of cultured osteoblast in the presences of the scaffold extracts. The growth of osteoblast on the scaffold were not deterred with the presence of any major oxidative stress factors as determined through oxidative stress profile studies using SOD, GSH and ROS assays. The nanobiocomposite scaffold evaluated in this study shows promising use in regards to facilitating osteoblast proliferation, growth and viability.
format	Article
author	Nurnadiah Ahmad, B. Hemabarathy Bharatham, Zariyantey Abdul Hamid, Nor Zulaikha Zulkipli,
spellingShingle	Nurnadiah Ahmad, B. Hemabarathy Bharatham, Zariyantey Abdul Hamid, Nor Zulaikha Zulkipli, Cytotoxicity and oxidative stress evaluation of Alginate/Cockle Shell powder nanobiocomposite bone scaffold on osteoblast
author_facet	Nurnadiah Ahmad, B. Hemabarathy Bharatham, Zariyantey Abdul Hamid, Nor Zulaikha Zulkipli,
author_sort	Nurnadiah Ahmad,
title	Cytotoxicity and oxidative stress evaluation of Alginate/Cockle Shell powder nanobiocomposite bone scaffold on osteoblast
title_short	Cytotoxicity and oxidative stress evaluation of Alginate/Cockle Shell powder nanobiocomposite bone scaffold on osteoblast
title_full	Cytotoxicity and oxidative stress evaluation of Alginate/Cockle Shell powder nanobiocomposite bone scaffold on osteoblast
title_fullStr	Cytotoxicity and oxidative stress evaluation of Alginate/Cockle Shell powder nanobiocomposite bone scaffold on osteoblast
title_full_unstemmed	Cytotoxicity and oxidative stress evaluation of Alginate/Cockle Shell powder nanobiocomposite bone scaffold on osteoblast
title_sort	cytotoxicity and oxidative stress evaluation of alginate/cockle shell powder nanobiocomposite bone scaffold on osteoblast
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2017
url	http://journalarticle.ukm.my/11463/ http://journalarticle.ukm.my/11463/ http://journalarticle.ukm.my/11463/1/16753-47156-1-SM.pdf
first_indexed	2023-09-18T20:00:25Z
last_indexed	2023-09-18T20:00:25Z
_version_	1777406810829881344

Cytotoxicity and oxidative stress evaluation of Alginate/Cockle Shell powder nanobiocomposite bone scaffold on osteoblast

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