Screening and evaluation of antioxidant activities of selected naphthalene compounds

The antioxidant activities of twelve naphthalene compounds containing (E)-1-((3-iodophenylimino)methyl) naphthalen-2-ol (NAPH1), (E)-1-((3-bromophenylimino) methyl) naphthalen-2-ol (NAPH2), E)-1-((4-bromo-2-(trifluoromethoxy) phenylimino) methyl) naphthalen-2-ol, (E)-1-((4-bromo-2-(trifluoromethoxy)...

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Main Authors:	Ozen, Tevfik, Macit, Mustafa, Toka, Mehmet
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/11498/ http://journalarticle.ukm.my/11498/ http://journalarticle.ukm.my/11498/1/16548-69330-1-PB.pdf

id	ukm-11498
recordtype	eprints
spelling	ukm-114982018-04-02T02:55:56Z http://journalarticle.ukm.my/11498/ Screening and evaluation of antioxidant activities of selected naphthalene compounds Ozen, Tevfik Macit, Mustafa Toka, Mehmet The antioxidant activities of twelve naphthalene compounds containing (E)-1-((3-iodophenylimino)methyl) naphthalen-2-ol (NAPH1), (E)-1-((3-bromophenylimino) methyl) naphthalen-2-ol (NAPH2), E)-1-((4-bromo-2-(trifluoromethoxy) phenylimino) methyl) naphthalen-2-ol, (E)-1-((4-bromo-2-(trifluoromethoxy) phenylimino) methyl)naphthalen-2-ol (NAPH3), (E)-1-((2-methoxy-5-(trifluoromethyl) phenylimino) methyl) naphthalen-2-ol (NAPH4), (E)-1-((naphthalen-2-ylimino) methyl) naphthalen-2-ol (NAPH5), (E)-1-((2-bromo-3-methylphenylimino) methyl) naphthalen-2-ol (NAPH6), (E)-N-((2-ethoxynaphthalen-1-yl)methylene)-3-methylaniline (NAPH7), (E)-4-ethoxy-N-((2-ethoxynaphthalen-1-yl) methylene) aniline (NAPH8), (E)-N-((2-ethoxynaphthalen-1-yl) methylene) naphthalen-1-amine (NAPH9), (E)-1-(2,5-difluorophenyl)-N-((2-ethoxynaphthalen-1-yl) methylene) methanamine (NAPH10), (E)-N-((2-ethoxynaphthalen-1-yl) methylene)-4-fluoroaniline (NAPH11), (E)-N-((2-ethoxynaphthalen-1-yl)methylene)-2-ethylaniline (NAPH12) were investigated in vitro by antioxidant activity (phosphomolybdenum assay), reducing power, H2O2 scavenging activity, metal chelating effects and lipid peroxidation. Scavenging activities of the naphthalen compounds were tested against 1,1-diphenyl-2-picrylhydrazyl, hydroxyl and superoxide anion radicals. Most of them are potent antioxidant, radical superoxide anion scavengers and in vitro inhibition of lipid peroxidation. The compounds; NAPH5, NAPH10 and NAPH12 were found to exhibit promising antioxidant profiles at 10 and 50 mM concentrations. Among these, NAPH5 at higher concentration was the most active compound in inhibiting lipid peroxidation as shown in the homogenates of kidney, heart and spleen. The presented results validate that NAPH5, NAPH10 and NAPH12 can be possessed as a source of antioxidant potential and a rich source of synthetic antioxidant for medicinal or foods. Penerbit Universiti Kebangsaan Malaysia 2018 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11498/1/16548-69330-1-PB.pdf Ozen, Tevfik and Macit, Mustafa and Toka, Mehmet (2018) Screening and evaluation of antioxidant activities of selected naphthalene compounds. Jurnal Sains Kesihatan Malaysia, 16 (1). pp. 45-55. ISSN 1675-8161 http://ejournal.ukm.my/jskm/issue/view/684
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The antioxidant activities of twelve naphthalene compounds containing (E)-1-((3-iodophenylimino)methyl) naphthalen-2-ol (NAPH1), (E)-1-((3-bromophenylimino) methyl) naphthalen-2-ol (NAPH2), E)-1-((4-bromo-2-(trifluoromethoxy) phenylimino) methyl) naphthalen-2-ol, (E)-1-((4-bromo-2-(trifluoromethoxy) phenylimino) methyl)naphthalen-2-ol (NAPH3), (E)-1-((2-methoxy-5-(trifluoromethyl) phenylimino) methyl) naphthalen-2-ol (NAPH4), (E)-1-((naphthalen-2-ylimino) methyl) naphthalen-2-ol (NAPH5), (E)-1-((2-bromo-3-methylphenylimino) methyl) naphthalen-2-ol (NAPH6), (E)-N-((2-ethoxynaphthalen-1-yl)methylene)-3-methylaniline (NAPH7), (E)-4-ethoxy-N-((2-ethoxynaphthalen-1-yl) methylene) aniline (NAPH8), (E)-N-((2-ethoxynaphthalen-1-yl) methylene) naphthalen-1-amine (NAPH9), (E)-1-(2,5-difluorophenyl)-N-((2-ethoxynaphthalen-1-yl) methylene) methanamine (NAPH10), (E)-N-((2-ethoxynaphthalen-1-yl) methylene)-4-fluoroaniline (NAPH11), (E)-N-((2-ethoxynaphthalen-1-yl)methylene)-2-ethylaniline (NAPH12) were investigated in vitro by antioxidant activity (phosphomolybdenum assay), reducing power, H2O2 scavenging activity, metal chelating effects and lipid peroxidation. Scavenging activities of the naphthalen compounds were tested against 1,1-diphenyl-2-picrylhydrazyl, hydroxyl and superoxide anion radicals. Most of them are potent antioxidant, radical superoxide anion scavengers and in vitro inhibition of lipid peroxidation. The compounds; NAPH5, NAPH10 and NAPH12 were found to exhibit promising antioxidant profiles at 10 and 50 mM concentrations. Among these, NAPH5 at higher concentration was the most active compound in inhibiting lipid peroxidation as shown in the homogenates of kidney, heart and spleen. The presented results validate that NAPH5, NAPH10 and NAPH12 can be possessed as a source of antioxidant potential and a rich source of synthetic antioxidant for medicinal or foods.
format	Article
author	Ozen, Tevfik Macit, Mustafa Toka, Mehmet
spellingShingle	Ozen, Tevfik Macit, Mustafa Toka, Mehmet Screening and evaluation of antioxidant activities of selected naphthalene compounds
author_facet	Ozen, Tevfik Macit, Mustafa Toka, Mehmet
author_sort	Ozen, Tevfik
title	Screening and evaluation of antioxidant activities of selected naphthalene compounds
title_short	Screening and evaluation of antioxidant activities of selected naphthalene compounds
title_full	Screening and evaluation of antioxidant activities of selected naphthalene compounds
title_fullStr	Screening and evaluation of antioxidant activities of selected naphthalene compounds
title_full_unstemmed	Screening and evaluation of antioxidant activities of selected naphthalene compounds
title_sort	screening and evaluation of antioxidant activities of selected naphthalene compounds
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/11498/ http://journalarticle.ukm.my/11498/ http://journalarticle.ukm.my/11498/1/16548-69330-1-PB.pdf
first_indexed	2023-09-18T19:01:01Z
last_indexed	2023-09-18T19:01:01Z
_version_	1777406816002506752

Screening and evaluation of antioxidant activities of selected naphthalene compounds

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