Anti-nociceptive effect of Caralluma edulis on peripheral and central pain pathways

The purpose of the present research was to evaluate the phytochemical content and analgesic effect of Caralluma edulis (Ce.Cr). Established methods were used for phytochemical analysis of plant. The anti-nociceptic activity of Ce.Cr was scrutinized using acetic acid-induced writhings, tail immersion...

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Main Authors:	Firdoos, Sundas, Khan, Arif-Ullah, Ali, Fawad
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2017
Online Access:	http://journalarticle.ukm.my/11545/ http://journalarticle.ukm.my/11545/ http://journalarticle.ukm.my/11545/1/24%20Sundas%20Firdoos.pdf

id	ukm-11545
recordtype	eprints
spelling	ukm-115452018-04-04T06:08:18Z http://journalarticle.ukm.my/11545/ Anti-nociceptive effect of Caralluma edulis on peripheral and central pain pathways Firdoos, Sundas Khan, Arif-Ullah Ali, Fawad The purpose of the present research was to evaluate the phytochemical content and analgesic effect of Caralluma edulis (Ce.Cr). Established methods were used for phytochemical analysis of plant. The anti-nociceptic activity of Ce.Cr was scrutinized using acetic acid-induced writhings, tail immersion and hot plate methods. Ce.Cr was tested positive for the presence of therapeutically active metabolites such as alkaloids, flavonoids, glycosides, phenol, tannins, terpenoids and saponins. Ce.Cr at the dose of 10, 30 and 100 mg/kg inhibited acetic acid-induced abdominal writhes and increase the latency time to thermal stimuli in both tail immersion and hot plate tests, similar to standard drug. These results showed that the ethanolic extract of Caralluma edulis possesses anti-nociceptive property. Penerbit Universiti Kebangsaan Malaysia 2017-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11545/1/24%20Sundas%20Firdoos.pdf Firdoos, Sundas and Khan, Arif-Ullah and Ali, Fawad (2017) Anti-nociceptive effect of Caralluma edulis on peripheral and central pain pathways. Sains Malaysiana, 46 (10). pp. 1859-1863. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol46num10_2017/contentsVol46num10_2017.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The purpose of the present research was to evaluate the phytochemical content and analgesic effect of Caralluma edulis (Ce.Cr). Established methods were used for phytochemical analysis of plant. The anti-nociceptic activity of Ce.Cr was scrutinized using acetic acid-induced writhings, tail immersion and hot plate methods. Ce.Cr was tested positive for the presence of therapeutically active metabolites such as alkaloids, flavonoids, glycosides, phenol, tannins, terpenoids and saponins. Ce.Cr at the dose of 10, 30 and 100 mg/kg inhibited acetic acid-induced abdominal writhes and increase the latency time to thermal stimuli in both tail immersion and hot plate tests, similar to standard drug. These results showed that the ethanolic extract of Caralluma edulis possesses anti-nociceptive property.
format	Article
author	Firdoos, Sundas Khan, Arif-Ullah Ali, Fawad
spellingShingle	Firdoos, Sundas Khan, Arif-Ullah Ali, Fawad Anti-nociceptive effect of Caralluma edulis on peripheral and central pain pathways
author_facet	Firdoos, Sundas Khan, Arif-Ullah Ali, Fawad
author_sort	Firdoos, Sundas
title	Anti-nociceptive effect of Caralluma edulis on peripheral and central pain pathways
title_short	Anti-nociceptive effect of Caralluma edulis on peripheral and central pain pathways
title_full	Anti-nociceptive effect of Caralluma edulis on peripheral and central pain pathways
title_fullStr	Anti-nociceptive effect of Caralluma edulis on peripheral and central pain pathways
title_full_unstemmed	Anti-nociceptive effect of Caralluma edulis on peripheral and central pain pathways
title_sort	anti-nociceptive effect of caralluma edulis on peripheral and central pain pathways
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2017
url	http://journalarticle.ukm.my/11545/ http://journalarticle.ukm.my/11545/ http://journalarticle.ukm.my/11545/1/24%20Sundas%20Firdoos.pdf
first_indexed	2023-09-18T20:00:35Z
last_indexed	2023-09-18T20:00:35Z
_version_	1777406821909135360

Anti-nociceptive effect of Caralluma edulis on peripheral and central pain pathways

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