Size and stability of curcumin niosomes from combinations of Tween 80 and Span 80

The ratios of Tween 80 to Span 80 are important in controlling the physicochemical characteristics of curcumin niosomes. Thus, in this study the correlations of combination of Tween 80 and Span 80 at different ratios with the size and stability of curcumin niosomes were investigated. Initially curcu...

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Main Authors:	Masrina Mohd Nadzir, Tan, Wei Fen, Abdul Rahman Mohamed, Siti Farhana Hisham
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2017
Online Access:	http://journalarticle.ukm.my/11714/ http://journalarticle.ukm.my/11714/ http://journalarticle.ukm.my/11714/1/22%20Masrina%20Mohd%20Nadzir.pdf

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spelling	ukm-117142018-05-30T00:41:56Z http://journalarticle.ukm.my/11714/ Size and stability of curcumin niosomes from combinations of Tween 80 and Span 80 Masrina Mohd Nadzir, Tan, Wei Fen Abdul Rahman Mohamed, Siti Farhana Hisham, The ratios of Tween 80 to Span 80 are important in controlling the physicochemical characteristics of curcumin niosomes. Thus, in this study the correlations of combination of Tween 80 and Span 80 at different ratios with the size and stability of curcumin niosomes were investigated. Initially curcumin was dissolved in chloroform and methanol (v/v= 3:1), followed by the preparation of niosomes by thin-film hydration method with the mole ratio of mixture of Tween 80 and Span 80 to cholesterol of 2:1. The ratios of Tween 80 to Span 80 in the mixture were set at 1:1, 1:9, 9:1, 2:3 and 3:2 with Hydrophilic-Lipophilic Balance (HLB) values of 9.65, 5.37, 13.93, 8.58 and 10.72, respectively. As expected, niosome barely formed at HLB value 13.93. This might be due to the molecule being hydrophilic and well hydrated which inhibits the formation of a stable bilayer in solution. It was found that the formulation which has higher Span 80 and lower HLB value leads to larger niosome before sonication. The largest niosome size achieved from Tween 80 to Span 80 ratio of 1:9 and 2:3 was 77.36 and 59.85 μm, respectively. On the other hand, for the ratio of 3:2, the largest niosome formed before sonication was less than 50.00 μm. After sonication, the niosome size reduced to less than 35.00 μm for all formulations. It was showed that formulation with Tween 80 to Span 80 ratio of 1:9 has superior curcumin entrapment efficiency and best stability during storage. The results demonstrated that appropriate ratio of Tween 80 to Span 80 was necessary for forming small and stable curcumin niosomes. Penerbit Universiti Kebangsaan Malaysia 2017 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11714/1/22%20Masrina%20Mohd%20Nadzir.pdf Masrina Mohd Nadzir, and Tan, Wei Fen and Abdul Rahman Mohamed, and Siti Farhana Hisham, (2017) Size and stability of curcumin niosomes from combinations of Tween 80 and Span 80. Sains Malaysiana, 46 (12). pp. 2455-2460. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol46num12_2017/contentsVol46num12_2017.htm
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The ratios of Tween 80 to Span 80 are important in controlling the physicochemical characteristics of curcumin niosomes. Thus, in this study the correlations of combination of Tween 80 and Span 80 at different ratios with the size and stability of curcumin niosomes were investigated. Initially curcumin was dissolved in chloroform and methanol (v/v= 3:1), followed by the preparation of niosomes by thin-film hydration method with the mole ratio of mixture of Tween 80 and Span 80 to cholesterol of 2:1. The ratios of Tween 80 to Span 80 in the mixture were set at 1:1, 1:9, 9:1, 2:3 and 3:2 with Hydrophilic-Lipophilic Balance (HLB) values of 9.65, 5.37, 13.93, 8.58 and 10.72, respectively. As expected, niosome barely formed at HLB value 13.93. This might be due to the molecule being hydrophilic and well hydrated which inhibits the formation of a stable bilayer in solution. It was found that the formulation which has higher Span 80 and lower HLB value leads to larger niosome before sonication. The largest niosome size achieved from Tween 80 to Span 80 ratio of 1:9 and 2:3 was 77.36 and 59.85 μm, respectively. On the other hand, for the ratio of 3:2, the largest niosome formed before sonication was less than 50.00 μm. After sonication, the niosome size reduced to less than 35.00 μm for all formulations. It was showed that formulation with Tween 80 to Span 80 ratio of 1:9 has superior curcumin entrapment efficiency and best stability during storage. The results demonstrated that appropriate ratio of Tween 80 to Span 80 was necessary for forming small and stable curcumin niosomes.
format	Article
author	Masrina Mohd Nadzir, Tan, Wei Fen Abdul Rahman Mohamed, Siti Farhana Hisham,
spellingShingle	Masrina Mohd Nadzir, Tan, Wei Fen Abdul Rahman Mohamed, Siti Farhana Hisham, Size and stability of curcumin niosomes from combinations of Tween 80 and Span 80
author_facet	Masrina Mohd Nadzir, Tan, Wei Fen Abdul Rahman Mohamed, Siti Farhana Hisham,
author_sort	Masrina Mohd Nadzir,
title	Size and stability of curcumin niosomes from combinations of Tween 80 and Span 80
title_short	Size and stability of curcumin niosomes from combinations of Tween 80 and Span 80
title_full	Size and stability of curcumin niosomes from combinations of Tween 80 and Span 80
title_fullStr	Size and stability of curcumin niosomes from combinations of Tween 80 and Span 80
title_full_unstemmed	Size and stability of curcumin niosomes from combinations of Tween 80 and Span 80
title_sort	size and stability of curcumin niosomes from combinations of tween 80 and span 80
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2017
url	http://journalarticle.ukm.my/11714/ http://journalarticle.ukm.my/11714/ http://journalarticle.ukm.my/11714/1/22%20Masrina%20Mohd%20Nadzir.pdf
first_indexed	2023-09-18T20:00:58Z
last_indexed	2023-09-18T20:00:58Z
_version_	1777406845778919424

Size and stability of curcumin niosomes from combinations of Tween 80 and Span 80

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