Prostatic diseases: is it toxic or genetic? Study of TNF alpha gene polymorphism and cigarette smoking in cases of prostate cancer and benign prostatic hyperplasia

Inflammation has been implicated as an etiological factor, in several human cancers. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. Besides genetic factors, environmental factors such as smoking are an importa...

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Main Authors:	M. Attalla, Sohayla, Housen, Maha, El-Samanoudy, Ayman Z., Abdalla, Hussein A.
Format:	Article
Language:	English
Published:	Malaysian Society of Applied Biology 2016
Online Access:	http://journalarticle.ukm.my/11825/ http://journalarticle.ukm.my/11825/ http://journalarticle.ukm.my/11825/1/45_02_20.pdf

id	ukm-11825
recordtype	eprints
spelling	ukm-118252018-07-02T03:53:36Z http://journalarticle.ukm.my/11825/ Prostatic diseases: is it toxic or genetic? Study of TNF alpha gene polymorphism and cigarette smoking in cases of prostate cancer and benign prostatic hyperplasia M. Attalla, Sohayla Housen, Maha El-Samanoudy, Ayman Z. Abdalla, Hussein A. Inflammation has been implicated as an etiological factor, in several human cancers. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. Besides genetic factors, environmental factors such as smoking are an important risk factor for prostate cancer. This study aimed to investigate whether 308 G/A single nucleotide polymorphism of tumor necrosis factor-α (TNF-α) gene promoter region was associated with outcomes of prostate cancer and to analyze the gene environment interaction between 308 G/A TNF polymorphism and cigarette smoking. A total of 282 patients with prostate cancer (143 smokers, 139 non smoker) and 212 patients with benign prostatic hyperplasia (105 smokers, 107 non smokers) along with 115 healthy control were enrolled in the study. Urinary Cotinine and serum TNF and PSA levels were measured using ELISA technique. TNF genotyping was performed using PCR-RFLP technique. Prostate cancer was significantly associated with TNF G/G genotype and this is accompanied by elevated plasma TNF, PSA and urinary Cotinine. Cancer smokers showed a high frequency of TNF-α 308 G allele compared with other patient groups associated with increased TNF levels. Results of this study support the hypothesis that polymorphism in proinflammatory genes may be important in prostate cancer development and the sequence variants in these inflammatory genes may interact with environmental modifiers such as cigarette smoking to increase prostate cancer risk. Malaysian Society of Applied Biology 2016-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11825/1/45_02_20.pdf M. Attalla, Sohayla and Housen, Maha and El-Samanoudy, Ayman Z. and Abdalla, Hussein A. (2016) Prostatic diseases: is it toxic or genetic? Study of TNF alpha gene polymorphism and cigarette smoking in cases of prostate cancer and benign prostatic hyperplasia. Malaysian Applied Biology, 45 (2). pp. 131-138. ISSN 0126-8643 http://www.mabjournal.com/index.php?option=com_content&view=article&id=565&catid=59:current-view&Itemid=56
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Inflammation has been implicated as an etiological factor, in several human cancers. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. Besides genetic factors, environmental factors such as smoking are an important risk factor for prostate cancer. This study aimed to investigate whether 308 G/A single nucleotide polymorphism of tumor necrosis factor-α (TNF-α) gene promoter region was associated with outcomes of prostate cancer and to analyze the gene environment interaction between 308 G/A TNF polymorphism and cigarette smoking. A total of 282 patients with prostate cancer (143 smokers, 139 non smoker) and 212 patients with benign prostatic hyperplasia (105 smokers, 107 non smokers) along with 115 healthy control were enrolled in the study. Urinary Cotinine and serum TNF and PSA levels were measured using ELISA technique. TNF genotyping was performed using PCR-RFLP technique. Prostate cancer was significantly associated with TNF G/G genotype and this is accompanied by elevated plasma TNF, PSA and urinary Cotinine. Cancer smokers showed a high frequency of TNF-α 308 G allele compared with other patient groups associated with increased TNF levels. Results of this study support the hypothesis that polymorphism in proinflammatory genes may be important in prostate cancer development and the sequence variants in these inflammatory genes may interact with environmental modifiers such as cigarette smoking to increase prostate cancer risk.
format	Article
author	M. Attalla, Sohayla Housen, Maha El-Samanoudy, Ayman Z. Abdalla, Hussein A.
spellingShingle	M. Attalla, Sohayla Housen, Maha El-Samanoudy, Ayman Z. Abdalla, Hussein A. Prostatic diseases: is it toxic or genetic? Study of TNF alpha gene polymorphism and cigarette smoking in cases of prostate cancer and benign prostatic hyperplasia
author_facet	M. Attalla, Sohayla Housen, Maha El-Samanoudy, Ayman Z. Abdalla, Hussein A.
author_sort	M. Attalla, Sohayla
title	Prostatic diseases: is it toxic or genetic? Study of TNF alpha gene polymorphism and cigarette smoking in cases of prostate cancer and benign prostatic hyperplasia
title_short	Prostatic diseases: is it toxic or genetic? Study of TNF alpha gene polymorphism and cigarette smoking in cases of prostate cancer and benign prostatic hyperplasia
title_full	Prostatic diseases: is it toxic or genetic? Study of TNF alpha gene polymorphism and cigarette smoking in cases of prostate cancer and benign prostatic hyperplasia
title_fullStr	Prostatic diseases: is it toxic or genetic? Study of TNF alpha gene polymorphism and cigarette smoking in cases of prostate cancer and benign prostatic hyperplasia
title_full_unstemmed	Prostatic diseases: is it toxic or genetic? Study of TNF alpha gene polymorphism and cigarette smoking in cases of prostate cancer and benign prostatic hyperplasia
title_sort	prostatic diseases: is it toxic or genetic? study of tnf alpha gene polymorphism and cigarette smoking in cases of prostate cancer and benign prostatic hyperplasia
publisher	Malaysian Society of Applied Biology
publishDate	2016
url	http://journalarticle.ukm.my/11825/ http://journalarticle.ukm.my/11825/ http://journalarticle.ukm.my/11825/1/45_02_20.pdf
first_indexed	2023-09-18T20:01:13Z
last_indexed	2023-09-18T20:01:13Z
_version_	1777406861877706752

Prostatic diseases: is it toxic or genetic? Study of TNF alpha gene polymorphism and cigarette smoking in cases of prostate cancer and benign prostatic hyperplasia

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