Optimum dose of sea cucumber (Stichopus chloronotus) extract for wound healing
In Malaysia, sea cucumber is also known as Gamat. Among the Malays, Gamat is frequently used as a traditional or folk medicine to relieve pain, to treat wounds and burns. It is also used as a tonic to provide extra energy. Stichopus chloronotus is one of the species of sea cucumber which is found in...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2017
|
| Online Access: | http://journalarticle.ukm.my/11867/ http://journalarticle.ukm.my/11867/ http://journalarticle.ukm.my/11867/1/9_mazliadiyana_et_al_pdf_73379.pdf |
| id |
ukm-11867 |
|---|---|
| recordtype |
eprints |
| spelling |
ukm-118672018-07-10T04:27:49Z http://journalarticle.ukm.my/11867/ Optimum dose of sea cucumber (Stichopus chloronotus) extract for wound healing Mazliadiyana M, Nazrun AS, Isa Naina Mohamed, In Malaysia, sea cucumber is also known as Gamat. Among the Malays, Gamat is frequently used as a traditional or folk medicine to relieve pain, to treat wounds and burns. It is also used as a tonic to provide extra energy. Stichopus chloronotus is one of the species of sea cucumber which is found in Malaysia. An experimental study was carried out to determine the optimum dose of aqueous extract of Stichopus chloronotus on the healing of wounds in rat model. A series of concentrations 0.1%, 0.5% and 1% aqueous extract emulsifying ointment mixed with Stichopus chloronotus was applied once a day for 10 days on the excision wound model. Changes in the wound area were measured using a caliper and photographs were taken on day 1, 3, 6, 8 and 10 after the wound creation. The wound reduction rate and macroscopic observation were evaluated to determine the optimum dose concentration. Results demonstrated that percentage of wound reduction and macroscopic observation of 0.5% aqueous extract Stichopus chloronotus emulsifying ointment mixed group was significantly higher than the other groups from day 6 following wound creation. In conclusion, 0.5% aqueous extract of Stichopus chloronotus emulsifying ointment mixture demonstrated the best dose for wound healing in a rat model. Pusat Perubatan Universiti Kebangsaan Malaysia 2017 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11867/1/9_mazliadiyana_et_al_pdf_73379.pdf Mazliadiyana M, and Nazrun AS, and Isa Naina Mohamed, (2017) Optimum dose of sea cucumber (Stichopus chloronotus) extract for wound healing. Medicine & Health, 12 (1). pp. 83-89. ISSN 2289-5728 http://www.medicineandhealthukm.com/toc/12/1 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
Universiti Kebangasaan Malaysia |
| building |
UKM Institutional Repository |
| collection |
Online Access |
| language |
English |
| description |
In Malaysia, sea cucumber is also known as Gamat. Among the Malays, Gamat is frequently used as a traditional or folk medicine to relieve pain, to treat wounds and burns. It is also used as a tonic to provide extra energy. Stichopus chloronotus is one of the species of sea cucumber which is found in Malaysia. An experimental study was carried out to determine the optimum dose of aqueous extract of Stichopus
chloronotus on the healing of wounds in rat model. A series of concentrations 0.1%, 0.5% and 1% aqueous extract emulsifying ointment mixed with Stichopus chloronotus was applied once a day for 10 days on the excision wound model. Changes in the wound area were measured using a caliper and photographs were taken on day 1, 3, 6, 8 and 10 after the wound creation. The wound reduction rate and macroscopic observation were evaluated to determine the optimum dose concentration. Results demonstrated that percentage of wound reduction and macroscopic observation of 0.5% aqueous extract Stichopus chloronotus emulsifying ointment mixed group was significantly higher than the other groups from day 6 following wound creation. In conclusion, 0.5% aqueous extract of Stichopus chloronotus emulsifying ointment mixture demonstrated the best dose for wound healing in a rat model. |
| format |
Article |
| author |
Mazliadiyana M, Nazrun AS, Isa Naina Mohamed, |
| spellingShingle |
Mazliadiyana M, Nazrun AS, Isa Naina Mohamed, Optimum dose of sea cucumber (Stichopus chloronotus) extract for wound healing |
| author_facet |
Mazliadiyana M, Nazrun AS, Isa Naina Mohamed, |
| author_sort |
Mazliadiyana M, |
| title |
Optimum dose of sea cucumber (Stichopus chloronotus) extract for wound healing |
| title_short |
Optimum dose of sea cucumber (Stichopus chloronotus) extract for wound healing |
| title_full |
Optimum dose of sea cucumber (Stichopus chloronotus) extract for wound healing |
| title_fullStr |
Optimum dose of sea cucumber (Stichopus chloronotus) extract for wound healing |
| title_full_unstemmed |
Optimum dose of sea cucumber (Stichopus chloronotus) extract for wound healing |
| title_sort |
optimum dose of sea cucumber (stichopus chloronotus) extract for wound healing |
| publisher |
Pusat Perubatan Universiti Kebangsaan Malaysia |
| publishDate |
2017 |
| url |
http://journalarticle.ukm.my/11867/ http://journalarticle.ukm.my/11867/ http://journalarticle.ukm.my/11867/1/9_mazliadiyana_et_al_pdf_73379.pdf |
| first_indexed |
2023-09-18T20:01:19Z |
| last_indexed |
2023-09-18T20:01:19Z |
| _version_ |
1777406868049625088 |