Synthesis of cephradine metal complexes and its anti-bacterial evaluation

Cephradine belongs to the first generation cephalosporin having a broad range of anti-bacterial activities. In the present work, Cephradine wasreacted with different metal salts. These metal salts were Iron, Copper, Cobalt and Nickel salts. All the complexes of Cephradine metals were synthesized a...

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Main Authors:	Hussain, Iqbal, Syed Salman, Iftikhar, Sarwat, Jan, Samin, Akhter, Junaid, Muhammad Ramzan, Ullah, Atta, Ullah, Riaz, S. Alsaid, Mansour, A. Shahat, Abdelaaty, Syed Hidayathulla
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/12060/ http://journalarticle.ukm.my/12060/ http://journalarticle.ukm.my/12060/1/UKM%20SAINSMalaysiana%2047%2804%29Apr%202018%2013.pdf

id	ukm-12060
recordtype	eprints
spelling	ukm-120602018-09-16T23:25:03Z http://journalarticle.ukm.my/12060/ Synthesis of cephradine metal complexes and its anti-bacterial evaluation Hussain, Iqbal Syed Salman, Iftikhar, Sarwat Jan, Samin Akhter, Junaid Muhammad Ramzan, Ullah, Atta Ullah, Riaz S. Alsaid, Mansour A. Shahat, Abdelaaty Syed Hidayathulla, Cephradine belongs to the first generation cephalosporin having a broad range of anti-bacterial activities. In the present work, Cephradine wasreacted with different metal salts. These metal salts were Iron, Copper, Cobalt and Nickel salts. All the complexes of Cephradine metals were synthesized at room temperature using a mechanical vibrator. The reactions yielded the coordinated complexes within 5-10 min with improved product yield. The synthesized complexes were analyzed for their antibacterial power using disc diffused assay. All the Cephradine complexes showed powerful antibacterial activity. The Co, Cu, Ni and Sn complexes showed good antibacterial activities 18.5 mm by Cu complexes against S. typhi, 17 mm against B. subtillus 16.5 mm against S. aureus, 16 mm against S. coccus. Similarly Sn complexes exhibited 17 mm zone of inhibition against S. coccus and 15.5 mm against B. subtillus. Cobalt and Ni complexes also shed significant inhibition activities against bacterial pathogenic bacterial strains. The study is of particular importance and new, using mechanical vibrator for the first time. The product yield is also comparatively good with short reaction time. Penerbit Universiti Kebangsaan Malaysia 2018-04 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12060/1/UKM%20SAINSMalaysiana%2047%2804%29Apr%202018%2013.pdf Hussain, Iqbal and Syed Salman, and Iftikhar, Sarwat and Jan, Samin and Akhter, Junaid and Muhammad Ramzan, and Ullah, Atta and Ullah, Riaz and S. Alsaid, Mansour and A. Shahat, Abdelaaty and Syed Hidayathulla, (2018) Synthesis of cephradine metal complexes and its anti-bacterial evaluation. Sains Malaysiana, 47 (4). pp. 749-754. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid47bil4_2018/KandunganJilid47Bil4_2018.htm
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Cephradine belongs to the first generation cephalosporin having a broad range of anti-bacterial activities. In the present work, Cephradine wasreacted with different metal salts. These metal salts were Iron, Copper, Cobalt and Nickel salts. All the complexes of Cephradine metals were synthesized at room temperature using a mechanical vibrator. The reactions yielded the coordinated complexes within 5-10 min with improved product yield. The synthesized complexes were analyzed for their antibacterial power using disc diffused assay. All the Cephradine complexes showed powerful antibacterial activity. The Co, Cu, Ni and Sn complexes showed good antibacterial activities 18.5 mm by Cu complexes against S. typhi, 17 mm against B. subtillus 16.5 mm against S. aureus, 16 mm against S. coccus. Similarly Sn complexes exhibited 17 mm zone of inhibition against S. coccus and 15.5 mm against B. subtillus. Cobalt and Ni complexes also shed significant inhibition activities against bacterial pathogenic bacterial strains. The study is of particular importance and new, using mechanical vibrator for the first time. The product yield is also comparatively good with short reaction time.
format	Article
author	Hussain, Iqbal Syed Salman, Iftikhar, Sarwat Jan, Samin Akhter, Junaid Muhammad Ramzan, Ullah, Atta Ullah, Riaz S. Alsaid, Mansour A. Shahat, Abdelaaty Syed Hidayathulla,
spellingShingle	Hussain, Iqbal Syed Salman, Iftikhar, Sarwat Jan, Samin Akhter, Junaid Muhammad Ramzan, Ullah, Atta Ullah, Riaz S. Alsaid, Mansour A. Shahat, Abdelaaty Syed Hidayathulla, Synthesis of cephradine metal complexes and its anti-bacterial evaluation
author_facet	Hussain, Iqbal Syed Salman, Iftikhar, Sarwat Jan, Samin Akhter, Junaid Muhammad Ramzan, Ullah, Atta Ullah, Riaz S. Alsaid, Mansour A. Shahat, Abdelaaty Syed Hidayathulla,
author_sort	Hussain, Iqbal
title	Synthesis of cephradine metal complexes and its anti-bacterial evaluation
title_short	Synthesis of cephradine metal complexes and its anti-bacterial evaluation
title_full	Synthesis of cephradine metal complexes and its anti-bacterial evaluation
title_fullStr	Synthesis of cephradine metal complexes and its anti-bacterial evaluation
title_full_unstemmed	Synthesis of cephradine metal complexes and its anti-bacterial evaluation
title_sort	synthesis of cephradine metal complexes and its anti-bacterial evaluation
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/12060/ http://journalarticle.ukm.my/12060/ http://journalarticle.ukm.my/12060/1/UKM%20SAINSMalaysiana%2047%2804%29Apr%202018%2013.pdf
first_indexed	2023-09-18T20:01:46Z
last_indexed	2023-09-18T20:01:46Z
_version_	1777406895978446848

Synthesis of cephradine metal complexes and its anti-bacterial evaluation

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