Inclusion of curcumin in β-cyclodextrins as potential drug delivery system: preparation, characterization and its preliminary cytotoxicity approaches

The development and application of organic based drug carrier in drug delivery system (DDSs) with greater efficacy and fewer side effects remains a significant challenge in modern scientific and medical research. The aim of current study was to evaluate the ability of β-cyclodextrin (β-CD) as drug d...

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Main Authors:	Muhammad Hasnor Ja'far, Nik Nur Syazni Nik Mohamed Kamal, Boon, Yih Hui, Muhammad Fahmi Kamaruzzaman, Nur Nadhirah Mohamad Zain, Noorfatimah Yahaya, Muggundha Raoov
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/12086/ http://journalarticle.ukm.my/12086/ http://journalarticle.ukm.my/12086/1/13%20Muhammad%20Hasnor%20Ja_far.pdf

id	ukm-12086
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spelling	ukm-120862018-09-22T10:55:18Z http://journalarticle.ukm.my/12086/ Inclusion of curcumin in β-cyclodextrins as potential drug delivery system: preparation, characterization and its preliminary cytotoxicity approaches Muhammad Hasnor Ja'far, Nik Nur Syazni Nik Mohamed Kamal, Boon, Yih Hui Muhammad Fahmi Kamaruzzaman, Nur Nadhirah Mohamad Zain, Noorfatimah Yahaya, Muggundha Raoov, The development and application of organic based drug carrier in drug delivery system (DDSs) with greater efficacy and fewer side effects remains a significant challenge in modern scientific and medical research. The aim of current study was to evaluate the ability of β-cyclodextrin (β-CD) as drug delivery carrier to encapsulate Curcumin (CUR), a promising chemotherapeutic that exhibits low aqueous solubility and poor bioavailability forming inclusion complex by kneading method to enhance its delivery to cancer cells. Different methods and analysis such as Fourier Transform Infrared (FTIR) spectrometer, 1H Nuclear Magnetic Resonance (1H NMR), X-Ray Diffraction (XRD), Scanning Electron Microscope (SEM) and Thermo-gravimetric Analysis (TGA) were employed to approve the successful formation of the inclusion complex where the aromatic ring of CUR has been encapsulated by the hydrophobic cavity of β-CD. UV absorption indicated that β-CD complex with CUR with an apparent formation constant of 1.09 × 10-8mol-1dm-3. Based on the data obtained by methylthiazole tetrazolium (MTT), β-CD showed that not only did it enhanced Curcumin delivery, but it also improved and promoted the anti-proliferative effect of CUR during the complexation rather than CUR alone on the MCF-7 human breast cancer cells at 24 h incubation period with IC50 lower than that of Curcumin alone. The toxicities of the β-CD-CUR towards MCF-7 cells were also compared to the free tamoxifen, Curcumin and β-CD. This study provides a preliminary toxicity evaluation based on β-CD-CUR inclusion complex as potential delivery system towards the selected cancer cells. Penerbit Universiti Kebangsaan Malaysia 2018-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12086/1/13%20Muhammad%20Hasnor%20Ja_far.pdf Muhammad Hasnor Ja'far, and Nik Nur Syazni Nik Mohamed Kamal, and Boon, Yih Hui and Muhammad Fahmi Kamaruzzaman, and Nur Nadhirah Mohamad Zain, and Noorfatimah Yahaya, and Muggundha Raoov, (2018) Inclusion of curcumin in β-cyclodextrins as potential drug delivery system: preparation, characterization and its preliminary cytotoxicity approaches. Sains Malaysiana, 47 (5). pp. 977-989. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol47num5_2018/contentsVol47num5_2018.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The development and application of organic based drug carrier in drug delivery system (DDSs) with greater efficacy and fewer side effects remains a significant challenge in modern scientific and medical research. The aim of current study was to evaluate the ability of β-cyclodextrin (β-CD) as drug delivery carrier to encapsulate Curcumin (CUR), a promising chemotherapeutic that exhibits low aqueous solubility and poor bioavailability forming inclusion complex by kneading method to enhance its delivery to cancer cells. Different methods and analysis such as Fourier Transform Infrared (FTIR) spectrometer, 1H Nuclear Magnetic Resonance (1H NMR), X-Ray Diffraction (XRD), Scanning Electron Microscope (SEM) and Thermo-gravimetric Analysis (TGA) were employed to approve the successful formation of the inclusion complex where the aromatic ring of CUR has been encapsulated by the hydrophobic cavity of β-CD. UV absorption indicated that β-CD complex with CUR with an apparent formation constant of 1.09 × 10-8mol-1dm-3. Based on the data obtained by methylthiazole tetrazolium (MTT), β-CD showed that not only did it enhanced Curcumin delivery, but it also improved and promoted the anti-proliferative effect of CUR during the complexation rather than CUR alone on the MCF-7 human breast cancer cells at 24 h incubation period with IC50 lower than that of Curcumin alone. The toxicities of the β-CD-CUR towards MCF-7 cells were also compared to the free tamoxifen, Curcumin and β-CD. This study provides a preliminary toxicity evaluation based on β-CD-CUR inclusion complex as potential delivery system towards the selected cancer cells.
format	Article
author	Muhammad Hasnor Ja'far, Nik Nur Syazni Nik Mohamed Kamal, Boon, Yih Hui Muhammad Fahmi Kamaruzzaman, Nur Nadhirah Mohamad Zain, Noorfatimah Yahaya, Muggundha Raoov,
spellingShingle	Muhammad Hasnor Ja'far, Nik Nur Syazni Nik Mohamed Kamal, Boon, Yih Hui Muhammad Fahmi Kamaruzzaman, Nur Nadhirah Mohamad Zain, Noorfatimah Yahaya, Muggundha Raoov, Inclusion of curcumin in β-cyclodextrins as potential drug delivery system: preparation, characterization and its preliminary cytotoxicity approaches
author_facet	Muhammad Hasnor Ja'far, Nik Nur Syazni Nik Mohamed Kamal, Boon, Yih Hui Muhammad Fahmi Kamaruzzaman, Nur Nadhirah Mohamad Zain, Noorfatimah Yahaya, Muggundha Raoov,
author_sort	Muhammad Hasnor Ja'far,
title	Inclusion of curcumin in β-cyclodextrins as potential drug delivery system: preparation, characterization and its preliminary cytotoxicity approaches
title_short	Inclusion of curcumin in β-cyclodextrins as potential drug delivery system: preparation, characterization and its preliminary cytotoxicity approaches
title_full	Inclusion of curcumin in β-cyclodextrins as potential drug delivery system: preparation, characterization and its preliminary cytotoxicity approaches
title_fullStr	Inclusion of curcumin in β-cyclodextrins as potential drug delivery system: preparation, characterization and its preliminary cytotoxicity approaches
title_full_unstemmed	Inclusion of curcumin in β-cyclodextrins as potential drug delivery system: preparation, characterization and its preliminary cytotoxicity approaches
title_sort	inclusion of curcumin in β-cyclodextrins as potential drug delivery system: preparation, characterization and its preliminary cytotoxicity approaches
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/12086/ http://journalarticle.ukm.my/12086/ http://journalarticle.ukm.my/12086/1/13%20Muhammad%20Hasnor%20Ja_far.pdf
first_indexed	2023-09-18T20:01:49Z
last_indexed	2023-09-18T20:01:49Z
_version_	1777406899629588480

Inclusion of curcumin in β-cyclodextrins as potential drug delivery system: preparation, characterization and its preliminary cytotoxicity approaches

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