Evolution by gene duplication, recombination and selection in MHC class I genes of Odorrana margaretae

Amphibians have undergone catastrophic declines worldwide and the major histocompatibility complex (MHC) is an attractive candidate for investigating the link between adaptive variation and individual fitness. Nonetheless, little research has been conducted to study the amphibians MHC genes. Thus, M...

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Main Authors:	Chen, Hu, Tan, Xiaorong, Han, Fuyao, Yao, Yongfang, Xu, Huailiang, Zhang, Mingwang
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/12386/ http://journalarticle.ukm.my/12386/ http://journalarticle.ukm.my/12386/1/05%20Hu%20Chen.pdf

id	ukm-12386
recordtype	eprints
spelling	ukm-123862018-12-07T23:19:24Z http://journalarticle.ukm.my/12386/ Evolution by gene duplication, recombination and selection in MHC class I genes of Odorrana margaretae Chen, Hu Tan, Xiaorong Han, Fuyao Yao, Yongfang Xu, Huailiang Zhang, Mingwang Amphibians have undergone catastrophic declines worldwide and the major histocompatibility complex (MHC) is an attractive candidate for investigating the link between adaptive variation and individual fitness. Nonetheless, little research has been conducted to study the amphibians MHC genes. Thus, MHC class Ia of Odorrana margaretae, a representative species of the Odorrana, was isolated and used to analyze the adaptive mechanism. We isolated alleles and determined evolution patterns of MHC class Ia in O. margaretae. The phylogenetic tree of MHC class Ia was reconstructed to understand the evolutionary relationship of Anura. In O. margaretae of MHC class Ia: there were more non-synonymous mutations compared to synonymous mutations; there are at least two loci; the recombination alleles took place for a large proportion (55.56%) of the alleles and recombination usually took place between whole exon of Ia genes of MHC class; positive selection sites were detected and most (10 of 19) located at the α1 and α2 domains belonged to the presumed ABS. The diversity of genes of MHC class Ia was led by recombination, gene duplication and positive selection. Trans-species polymorphisms of anuran genes of MHC class Ia were evident in anurans. Therefore, the MHC class Ia present demonstrative candidates for investigating the link between adaptive variation and individual fitness. We argue that knowledge of the MHC of other anuran lineage, especially focusing a genus such as O. margaretae, should provide an overall more complete picture of the organization of MHC in anurans. Penerbit Universiti Kebangsaan Malaysia 2018-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12386/1/05%20Hu%20Chen.pdf Chen, Hu and Tan, Xiaorong and Han, Fuyao and Yao, Yongfang and Xu, Huailiang and Zhang, Mingwang (2018) Evolution by gene duplication, recombination and selection in MHC class I genes of Odorrana margaretae. Sains Malaysiana, 47 (9). pp. 1979-1989. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol47num9_2018/contentsVol47num9_2018.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Amphibians have undergone catastrophic declines worldwide and the major histocompatibility complex (MHC) is an attractive candidate for investigating the link between adaptive variation and individual fitness. Nonetheless, little research has been conducted to study the amphibians MHC genes. Thus, MHC class Ia of Odorrana margaretae, a representative species of the Odorrana, was isolated and used to analyze the adaptive mechanism. We isolated alleles and determined evolution patterns of MHC class Ia in O. margaretae. The phylogenetic tree of MHC class Ia was reconstructed to understand the evolutionary relationship of Anura. In O. margaretae of MHC class Ia: there were more non-synonymous mutations compared to synonymous mutations; there are at least two loci; the recombination alleles took place for a large proportion (55.56%) of the alleles and recombination usually took place between whole exon of Ia genes of MHC class; positive selection sites were detected and most (10 of 19) located at the α1 and α2 domains belonged to the presumed ABS. The diversity of genes of MHC class Ia was led by recombination, gene duplication and positive selection. Trans-species polymorphisms of anuran genes of MHC class Ia were evident in anurans. Therefore, the MHC class Ia present demonstrative candidates for investigating the link between adaptive variation and individual fitness. We argue that knowledge of the MHC of other anuran lineage, especially focusing a genus such as O. margaretae, should provide an overall more complete picture of the organization of MHC in anurans.
format	Article
author	Chen, Hu Tan, Xiaorong Han, Fuyao Yao, Yongfang Xu, Huailiang Zhang, Mingwang
spellingShingle	Chen, Hu Tan, Xiaorong Han, Fuyao Yao, Yongfang Xu, Huailiang Zhang, Mingwang Evolution by gene duplication, recombination and selection in MHC class I genes of Odorrana margaretae
author_facet	Chen, Hu Tan, Xiaorong Han, Fuyao Yao, Yongfang Xu, Huailiang Zhang, Mingwang
author_sort	Chen, Hu
title	Evolution by gene duplication, recombination and selection in MHC class I genes of Odorrana margaretae
title_short	Evolution by gene duplication, recombination and selection in MHC class I genes of Odorrana margaretae
title_full	Evolution by gene duplication, recombination and selection in MHC class I genes of Odorrana margaretae
title_fullStr	Evolution by gene duplication, recombination and selection in MHC class I genes of Odorrana margaretae
title_full_unstemmed	Evolution by gene duplication, recombination and selection in MHC class I genes of Odorrana margaretae
title_sort	evolution by gene duplication, recombination and selection in mhc class i genes of odorrana margaretae
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/12386/ http://journalarticle.ukm.my/12386/ http://journalarticle.ukm.my/12386/1/05%20Hu%20Chen.pdf
first_indexed	2023-09-18T20:02:29Z
last_indexed	2023-09-18T20:02:29Z
_version_	1777406941523345408

Evolution by gene duplication, recombination and selection in MHC class I genes of Odorrana margaretae

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