Antibacterial activity and major constituents of Polyalthia cinnamomea basic fraction

Antibacterial activity and major constituents of Polyalthia cinnamomea basic fraction

Polyalthia cinnamomea Hook.f. & Thomson (Annonaceae) or locally known as ‘Larak Batu Bukit’, ‘Pisang-pisang’, ‘Sugao’ and ‘Sigumpet Hutan’ is a small woody plant found throughout Malaysia and Singapore. In this study, the basic chemical components from the leaves of the plant were fractionated a...

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Main Authors: Puteri I.A.M.Mahmud, Wan A. Yaacob, Nazlina Ibrahim, Muntaz Abu Bakar
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:http://journalarticle.ukm.my/12395/
http://journalarticle.ukm.my/12395/
http://journalarticle.ukm.my/12395/1/14%20Puteri%20I.A.M.%20Mahmud.pdf
id ukm-12395
recordtype eprints
spelling ukm-123952018-12-07T23:28:51Z http://journalarticle.ukm.my/12395/ Antibacterial activity and major constituents of Polyalthia cinnamomea basic fraction Puteri I.A.M.Mahmud, Wan A. Yaacob, Nazlina Ibrahim, Muntaz Abu Bakar, Polyalthia cinnamomea Hook.f. & Thomson (Annonaceae) or locally known as ‘Larak Batu Bukit’, ‘Pisang-pisang’, ‘Sugao’ and ‘Sigumpet Hutan’ is a small woody plant found throughout Malaysia and Singapore. In this study, the basic chemical components from the leaves of the plant were fractionated and the antibacterial activity as well as the major constituents of the basic fraction was determined. To the best of our knowledge, this is the first study being carried out on the bioactivity and phytochemistry of P. cinnamomea. The basic fraction remarkably inhibited the growth of ten bacteria tested except one. The biggest inhibitory diameter and the lowest minimum inhibitory concentration were 19.0±4.6 mm and 0.125 mg/mL against respective Bacillus subtilis and Bacillus thuringiensis. Gas chromatography-mass spectrometry (GCMS) analysis of the basic fraction identified four major cyclosiloxanes of octamethylcyclotetrasiloxane (18.1%), decamethylcyclopentasiloxane (16.4%), dodecamethylcyclohexasiloxane (14.1%) and tetradecamethylcycloheptasiloxane (6.0%). The knowledge of the antibacterial potential of P. cinnamomea basic fraction and the major constituents present in the fraction can be utilized in the fields of natural products, pharmaceutical, cosmetic and personel care industries. Penerbit Universiti Kebangsaan Malaysia 2018-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12395/1/14%20Puteri%20I.A.M.%20Mahmud.pdf Puteri I.A.M.Mahmud, and Wan A. Yaacob, and Nazlina Ibrahim, and Muntaz Abu Bakar, (2018) Antibacterial activity and major constituents of Polyalthia cinnamomea basic fraction. Sains Malaysiana, 47 (9). pp. 2063-2071. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol47num9_2018/contentsVol47num9_2018.html
repository_type Digital Repository
institution_category Local University
institution Universiti Kebangasaan Malaysia
building UKM Institutional Repository
collection Online Access
language English
description Polyalthia cinnamomea Hook.f. & Thomson (Annonaceae) or locally known as ‘Larak Batu Bukit’, ‘Pisang-pisang’, ‘Sugao’ and ‘Sigumpet Hutan’ is a small woody plant found throughout Malaysia and Singapore. In this study, the basic chemical components from the leaves of the plant were fractionated and the antibacterial activity as well as the major constituents of the basic fraction was determined. To the best of our knowledge, this is the first study being carried out on the bioactivity and phytochemistry of P. cinnamomea. The basic fraction remarkably inhibited the growth of ten bacteria tested except one. The biggest inhibitory diameter and the lowest minimum inhibitory concentration were 19.0±4.6 mm and 0.125 mg/mL against respective Bacillus subtilis and Bacillus thuringiensis. Gas chromatography-mass spectrometry (GCMS) analysis of the basic fraction identified four major cyclosiloxanes of octamethylcyclotetrasiloxane (18.1%), decamethylcyclopentasiloxane (16.4%), dodecamethylcyclohexasiloxane (14.1%) and tetradecamethylcycloheptasiloxane (6.0%). The knowledge of the antibacterial potential of P. cinnamomea basic fraction and the major constituents present in the fraction can be utilized in the fields of natural products, pharmaceutical, cosmetic and personel care industries.
format Article
author Puteri I.A.M.Mahmud,
Wan A. Yaacob,
Nazlina Ibrahim,
Muntaz Abu Bakar,
spellingShingle Puteri I.A.M.Mahmud,
Wan A. Yaacob,
Nazlina Ibrahim,
Muntaz Abu Bakar,
Antibacterial activity and major constituents of Polyalthia cinnamomea basic fraction
author_facet Puteri I.A.M.Mahmud,
Wan A. Yaacob,
Nazlina Ibrahim,
Muntaz Abu Bakar,
author_sort Puteri I.A.M.Mahmud,
title Antibacterial activity and major constituents of Polyalthia cinnamomea basic fraction
title_short Antibacterial activity and major constituents of Polyalthia cinnamomea basic fraction
title_full Antibacterial activity and major constituents of Polyalthia cinnamomea basic fraction
title_fullStr Antibacterial activity and major constituents of Polyalthia cinnamomea basic fraction
title_full_unstemmed Antibacterial activity and major constituents of Polyalthia cinnamomea basic fraction
title_sort antibacterial activity and major constituents of polyalthia cinnamomea basic fraction
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2018
url http://journalarticle.ukm.my/12395/
http://journalarticle.ukm.my/12395/
http://journalarticle.ukm.my/12395/1/14%20Puteri%20I.A.M.%20Mahmud.pdf
first_indexed 2023-09-18T20:02:31Z
last_indexed 2023-09-18T20:02:31Z
_version_ 1777406942860279808

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