Challenges in predicting risks of premature coronary artery disease (PCAD)

Coronary artery disease (CAD) predominantly manifests in older population above the age of 60 years old. The incidence of CAD in younger individuals has been reported and is called premature CAD (pCAD). The prevalence for pCAD in individuals below 45 years old is about 3-10% worldwide. Advances in r...

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Main Authors:	Muhammad Faizan A. Shukor, Noor Akmal Shareela Ismail, Wan Zurinah Wan Ngah
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/12525/ http://journalarticle.ukm.my/12525/ http://journalarticle.ukm.my/12525/1/31%20MUHAMMAD%20FAIZAN%20A.%20SHUKOR.pdf

id	ukm-12525
recordtype	eprints
spelling	ukm-125252019-01-28T21:41:27Z http://journalarticle.ukm.my/12525/ Challenges in predicting risks of premature coronary artery disease (PCAD) Muhammad Faizan A. Shukor, Noor Akmal Shareela Ismail, Wan Zurinah Wan Ngah, Coronary artery disease (CAD) predominantly manifests in older population above the age of 60 years old. The incidence of CAD in younger individuals has been reported and is called premature CAD (pCAD). The prevalence for pCAD in individuals below 45 years old is about 3-10% worldwide. Advances in risk prediction are of great importance as absolute values of risk factors sometimes correlate poorly with individuals. The measurement of traditional risk factors such as cholesterol level and blood pressure might be inadequate to predict risk for pCAD and therefore new biomarkers are required. The introduction of omics technology offers insight into the mechanism and interactions involved during disease progression and open the possibilities of discovering new biomarkers. Currently, new potential biomarkers for pCAD have been explored such as homocysteine, apolipoproteins, microRNAs and single nucleotide polymorphisms. In this review, we discussed the associated risk factors for pCAD, several reported and newly proposed biomarkers and their potential to be used clinically. Penerbit Universiti Kebangsaan Malaysia 2018-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12525/1/31%20MUHAMMAD%20FAIZAN%20A.%20SHUKOR.pdf Muhammad Faizan A. Shukor, and Noor Akmal Shareela Ismail, and Wan Zurinah Wan Ngah, (2018) Challenges in predicting risks of premature coronary artery disease (PCAD). Sains Malaysiana, 47 (10). pp. 2543-2556. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid47bil10_2018/KandunganJilid47Bil10_2018.htm
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Coronary artery disease (CAD) predominantly manifests in older population above the age of 60 years old. The incidence of CAD in younger individuals has been reported and is called premature CAD (pCAD). The prevalence for pCAD in individuals below 45 years old is about 3-10% worldwide. Advances in risk prediction are of great importance as absolute values of risk factors sometimes correlate poorly with individuals. The measurement of traditional risk factors such as cholesterol level and blood pressure might be inadequate to predict risk for pCAD and therefore new biomarkers are required. The introduction of omics technology offers insight into the mechanism and interactions involved during disease progression and open the possibilities of discovering new biomarkers. Currently, new potential biomarkers for pCAD have been explored such as homocysteine, apolipoproteins, microRNAs and single nucleotide polymorphisms. In this review, we discussed the associated risk factors for pCAD, several reported and newly proposed biomarkers and their potential to be used clinically.
format	Article
author	Muhammad Faizan A. Shukor, Noor Akmal Shareela Ismail, Wan Zurinah Wan Ngah,
spellingShingle	Muhammad Faizan A. Shukor, Noor Akmal Shareela Ismail, Wan Zurinah Wan Ngah, Challenges in predicting risks of premature coronary artery disease (PCAD)
author_facet	Muhammad Faizan A. Shukor, Noor Akmal Shareela Ismail, Wan Zurinah Wan Ngah,
author_sort	Muhammad Faizan A. Shukor,
title	Challenges in predicting risks of premature coronary artery disease (PCAD)
title_short	Challenges in predicting risks of premature coronary artery disease (PCAD)
title_full	Challenges in predicting risks of premature coronary artery disease (PCAD)
title_fullStr	Challenges in predicting risks of premature coronary artery disease (PCAD)
title_full_unstemmed	Challenges in predicting risks of premature coronary artery disease (PCAD)
title_sort	challenges in predicting risks of premature coronary artery disease (pcad)
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/12525/ http://journalarticle.ukm.my/12525/ http://journalarticle.ukm.my/12525/1/31%20MUHAMMAD%20FAIZAN%20A.%20SHUKOR.pdf
first_indexed	2023-09-18T20:02:48Z
last_indexed	2023-09-18T20:02:48Z
_version_	1777406961225039872

Challenges in predicting risks of premature coronary artery disease (PCAD)

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