Challenges in parathyroid cancers: a review

Parathyroid carcinomas are rare neoplasms, with a reported incidence of less than 1% of cases of primary hyperparathyroidism. Diagnosis and treatment of parathyroid carcinoma remains a challenge, as many of the pathologic features are neither sensitive nor specific in differentiating from benign par...

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Main Authors:	Sujith Indeewara Wijerathne, Rajeev Parameswaran
Format:	Article
Language:	English
Published:	Pusat Perubatan Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/12550/ http://journalarticle.ukm.my/12550/ http://journalarticle.ukm.my/12550/1/2._sujith__rajeev.pdf

id	ukm-12550
recordtype	eprints
spelling	ukm-125502019-02-14T13:51:52Z http://journalarticle.ukm.my/12550/ Challenges in parathyroid cancers: a review Sujith Indeewara Wijerathne, Rajeev Parameswaran, Parathyroid carcinomas are rare neoplasms, with a reported incidence of less than 1% of cases of primary hyperparathyroidism. Diagnosis and treatment of parathyroid carcinoma remains a challenge, as many of the pathologic features are neither sensitive nor specific in differentiating from benign parathyroid lesions. The rule of 3’s (serum calcium of more than 3mmol/L and size of the adenoma being more than 3cm) is helpful in risk identifying a cancer. Ultrasound of the neck and Tc-99m pertechnetate/Tc-99m sestamibi (MIBI) scan remains the two main modalities of investigation of parathyroid disease. Although en-bloc treatment is recommended for parathyroid cancer, it is only performed in up to 12% of cases. This review illustrates the challenges in diagnosis and treatment of parathyroid carcinoma. Pusat Perubatan Universiti Kebangsaan Malaysia 2018 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12550/1/2._sujith__rajeev.pdf Sujith Indeewara Wijerathne, and Rajeev Parameswaran, (2018) Challenges in parathyroid cancers: a review. Journal of Surgical Academia, 8 (1). pp. 5-15. ISSN 2231-7481 http://jsurgacad.com/toc/8/1
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Parathyroid carcinomas are rare neoplasms, with a reported incidence of less than 1% of cases of primary hyperparathyroidism. Diagnosis and treatment of parathyroid carcinoma remains a challenge, as many of the pathologic features are neither sensitive nor specific in differentiating from benign parathyroid lesions. The rule of 3’s (serum calcium of more than 3mmol/L and size of the adenoma being more than 3cm) is helpful in risk identifying a cancer. Ultrasound of the neck and Tc-99m pertechnetate/Tc-99m sestamibi (MIBI) scan remains the two main modalities of investigation of parathyroid disease. Although en-bloc treatment is recommended for parathyroid cancer, it is only performed in up to 12% of cases. This review illustrates the challenges in diagnosis and treatment of parathyroid carcinoma.
format	Article
author	Sujith Indeewara Wijerathne, Rajeev Parameswaran,
spellingShingle	Sujith Indeewara Wijerathne, Rajeev Parameswaran, Challenges in parathyroid cancers: a review
author_facet	Sujith Indeewara Wijerathne, Rajeev Parameswaran,
author_sort	Sujith Indeewara Wijerathne,
title	Challenges in parathyroid cancers: a review
title_short	Challenges in parathyroid cancers: a review
title_full	Challenges in parathyroid cancers: a review
title_fullStr	Challenges in parathyroid cancers: a review
title_full_unstemmed	Challenges in parathyroid cancers: a review
title_sort	challenges in parathyroid cancers: a review
publisher	Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/12550/ http://journalarticle.ukm.my/12550/ http://journalarticle.ukm.my/12550/1/2._sujith__rajeev.pdf
first_indexed	2023-09-18T20:02:52Z
last_indexed	2023-09-18T20:02:52Z
_version_	1777406964705263616

Challenges in parathyroid cancers: a review

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