(-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast Glaciozyma antarctica PI12

A new dipeptide, (-)-glaciantarcin (1) and three known compounds, cyclo(-Pro-Gly) (2), 1-(2-deoxypentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (3) and vidarabine (Ara-A) (4), were isolated from Glaciozyma antarctica PI12, a cold-adapted yeast. The chemical structures were elucidated by FT-IR,...

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Main Authors:	Andi R. Rosandy, Yeoh, Chian Ying, Cheah, Yoke Kqueen, Seng, Joe Lim, Jalifah Latip, Abdul Munir Abd. Murad, Muntaz Abu Bakar, Rozida Mohd. Khalid
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/12650/ http://journalarticle.ukm.my/12650/ http://journalarticle.ukm.my/12650/1/12%20Andi%20R.%20Rosandy.pdf

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recordtype	eprints
spelling	ukm-126502019-03-17T11:33:47Z http://journalarticle.ukm.my/12650/ (-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast Glaciozyma antarctica PI12 Andi R. Rosandy, Yeoh, Chian Ying Cheah, Yoke Kqueen Seng, Joe Lim Jalifah Latip, Abdul Munir Abd. Murad, Muntaz Abu Bakar, Rozida Mohd. Khalid, A new dipeptide, (-)-glaciantarcin (1) and three known compounds, cyclo(-Pro-Gly) (2), 1-(2-deoxypentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (3) and vidarabine (Ara-A) (4), were isolated from Glaciozyma antarctica PI12, a cold-adapted yeast. The chemical structures were elucidated by FT-IR, NMR and mass spectrometry. The cytotoxicity and antioxidant activities of compounds 1-4 were evaluated by using the MTT bioassay on MCF-7 (human breast cancer cell line), PC-3 (human prostate cancer cell line) and HEK-293 (normal human embryonic kidney cell line) and DPPH free radical scavenging activity, respectively. At concentration of 400 μM, all compounds showed the highest activity on MCF-7, with compound 1 at 65%, compound 2 (70%), compound 3 (66%) and compound 4 (58%) cell viability. All compounds exhibited weak antioxidant properties. To the best of our knowledge, this is the first report of compounds 1-4 from Glaciozyma antactica. Penerbit Universiti Kebangsaan Malaysia 2018-11 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12650/1/12%20Andi%20R.%20Rosandy.pdf Andi R. Rosandy, and Yeoh, Chian Ying and Cheah, Yoke Kqueen and Seng, Joe Lim and Jalifah Latip, and Abdul Munir Abd. Murad, and Muntaz Abu Bakar, and Rozida Mohd. Khalid, (2018) (-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast Glaciozyma antarctica PI12. Sains Malaysiana, 47 (11). pp. 2693-2698. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid47bil11_2018/KandunganJilid47Bil11_2018.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	A new dipeptide, (-)-glaciantarcin (1) and three known compounds, cyclo(-Pro-Gly) (2), 1-(2-deoxypentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (3) and vidarabine (Ara-A) (4), were isolated from Glaciozyma antarctica PI12, a cold-adapted yeast. The chemical structures were elucidated by FT-IR, NMR and mass spectrometry. The cytotoxicity and antioxidant activities of compounds 1-4 were evaluated by using the MTT bioassay on MCF-7 (human breast cancer cell line), PC-3 (human prostate cancer cell line) and HEK-293 (normal human embryonic kidney cell line) and DPPH free radical scavenging activity, respectively. At concentration of 400 μM, all compounds showed the highest activity on MCF-7, with compound 1 at 65%, compound 2 (70%), compound 3 (66%) and compound 4 (58%) cell viability. All compounds exhibited weak antioxidant properties. To the best of our knowledge, this is the first report of compounds 1-4 from Glaciozyma antactica.
format	Article
author	Andi R. Rosandy, Yeoh, Chian Ying Cheah, Yoke Kqueen Seng, Joe Lim Jalifah Latip, Abdul Munir Abd. Murad, Muntaz Abu Bakar, Rozida Mohd. Khalid,
spellingShingle	Andi R. Rosandy, Yeoh, Chian Ying Cheah, Yoke Kqueen Seng, Joe Lim Jalifah Latip, Abdul Munir Abd. Murad, Muntaz Abu Bakar, Rozida Mohd. Khalid, (-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast Glaciozyma antarctica PI12
author_facet	Andi R. Rosandy, Yeoh, Chian Ying Cheah, Yoke Kqueen Seng, Joe Lim Jalifah Latip, Abdul Munir Abd. Murad, Muntaz Abu Bakar, Rozida Mohd. Khalid,
author_sort	Andi R. Rosandy,
title	(-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast Glaciozyma antarctica PI12
title_short	(-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast Glaciozyma antarctica PI12
title_full	(-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast Glaciozyma antarctica PI12
title_fullStr	(-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast Glaciozyma antarctica PI12
title_full_unstemmed	(-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast Glaciozyma antarctica PI12
title_sort	(-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast glaciozyma antarctica pi12
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/12650/ http://journalarticle.ukm.my/12650/ http://journalarticle.ukm.my/12650/1/12%20Andi%20R.%20Rosandy.pdf
first_indexed	2023-09-18T20:03:05Z
last_indexed	2023-09-18T20:03:05Z
_version_	1777406978841116672

(-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast Glaciozyma antarctica PI12

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