Age estimation by using aspartic acid racemization from purified elastin of aorta

Age estimation is the one of biological profiles which plays an important role in identification in forensic field. The application of biochemical approach known as aspartic acid racemization in human provides more accuracy and less error of estimated age in age determination. During aging, amino ac...

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Main Authors:	Komutrattananont P, Pasuk Mahakkanukrauh
Format:	Article
Language:	English
Published:	Pusat Perubatan Universiti Kebangsaan Malaysia 2017
Online Access:	http://journalarticle.ukm.my/12677/ http://journalarticle.ukm.my/12677/ http://journalarticle.ukm.my/12677/1/2_komutrattananont_et_al_pdf_18388.pdf

id	ukm-12677
recordtype	eprints
spelling	ukm-126772019-03-17T12:02:05Z http://journalarticle.ukm.my/12677/ Age estimation by using aspartic acid racemization from purified elastin of aorta Komutrattananont P, Pasuk Mahakkanukrauh, Age estimation is the one of biological profiles which plays an important role in identification in forensic field. The application of biochemical approach known as aspartic acid racemization in human provides more accuracy and less error of estimated age in age determination. During aging, amino acids within protein transform between D-and L-form (racemization), which results in increasing concentration of D-amino acids. This change of amino acids is related to aging. Aspartic acid has been generally applied in racemization because it has fastest rate of racemization. Racemization of aspartic acid not only takes place in teeth and many kinds of bone, but also can occur in the flexible structure which contain mostly elastin. For example, skin yellow ligament, lung parenchyma, and aorta. Elastin is essential protein which is comprised most composition of several structures and it is major content in the elastic fibers. Additionally, elastin is the longest lasting protein in the body with slow metabolic turnover rate. Recently, there is a purification technique to obtain only single protein in human aorta. There was a good correlation between degree of racemization (D/L ratio) and age. Therefore, aspartic acid racemization by purifies elastin from aorta is a one of indicator for age estimation. This review provides an overview of aspartic acid racemization, elastin protein, purification method bases on racemization and the application of D/L ratio by purified of elastin in artery for age estimation. Pusat Perubatan Universiti Kebangsaan Malaysia 2017 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12677/1/2_komutrattananont_et_al_pdf_18388.pdf Komutrattananont P, and Pasuk Mahakkanukrauh, (2017) Age estimation by using aspartic acid racemization from purified elastin of aorta. Medicine & Health, 12 (2). pp. 170-178. ISSN 2289-5728 http://www.medicineandhealthukm.com/toc/12/2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Age estimation is the one of biological profiles which plays an important role in identification in forensic field. The application of biochemical approach known as aspartic acid racemization in human provides more accuracy and less error of estimated age in age determination. During aging, amino acids within protein transform between D-and L-form (racemization), which results in increasing concentration of D-amino acids. This change of amino acids is related to aging. Aspartic acid has been generally applied in racemization because it has fastest rate of racemization. Racemization of aspartic acid not only takes place in teeth and many kinds of bone, but also can occur in the flexible structure which contain mostly elastin. For example, skin yellow ligament, lung parenchyma, and aorta. Elastin is essential protein which is comprised most composition of several structures and it is major content in the elastic fibers. Additionally, elastin is the longest lasting protein in the body with slow metabolic turnover rate. Recently, there is a purification technique to obtain only single protein in human aorta. There was a good correlation between degree of racemization (D/L ratio) and age. Therefore, aspartic acid racemization by purifies elastin from aorta is a one of indicator for age estimation. This review provides an overview of aspartic acid racemization, elastin protein, purification method bases on racemization and the application of D/L ratio by purified of elastin in artery for age estimation.
format	Article
author	Komutrattananont P, Pasuk Mahakkanukrauh,
spellingShingle	Komutrattananont P, Pasuk Mahakkanukrauh, Age estimation by using aspartic acid racemization from purified elastin of aorta
author_facet	Komutrattananont P, Pasuk Mahakkanukrauh,
author_sort	Komutrattananont P,
title	Age estimation by using aspartic acid racemization from purified elastin of aorta
title_short	Age estimation by using aspartic acid racemization from purified elastin of aorta
title_full	Age estimation by using aspartic acid racemization from purified elastin of aorta
title_fullStr	Age estimation by using aspartic acid racemization from purified elastin of aorta
title_full_unstemmed	Age estimation by using aspartic acid racemization from purified elastin of aorta
title_sort	age estimation by using aspartic acid racemization from purified elastin of aorta
publisher	Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate	2017
url	http://journalarticle.ukm.my/12677/ http://journalarticle.ukm.my/12677/ http://journalarticle.ukm.my/12677/1/2_komutrattananont_et_al_pdf_18388.pdf
first_indexed	2023-09-18T20:03:09Z
last_indexed	2023-09-18T20:03:09Z
_version_	1777406982615990272

Age estimation by using aspartic acid racemization from purified elastin of aorta

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