Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study

Fluid replacement is the mainstay treatment for diabetic ketoacidosis (DKA). Currently, the best choice of fluids is still debatable. An amount of 0.9% sodium chloride is commonly used. Sterofundin® is an alternative crystalloid that is assumed to expedite resolution of acidosis. Advantages in stero...

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Main Authors:	Rossman H, Mahathar AW, Nik Azlan Nik Muhamad
Format:	Article
Language:	English
Published:	Pusat Perubatan Universiti Kebangsaan Malaysia 2017
Online Access:	http://journalarticle.ukm.my/12678/ http://journalarticle.ukm.my/12678/ http://journalarticle.ukm.my/12678/1/3_rossman_et_al_pdf_57811.pdf

id	ukm-12678
recordtype	eprints
spelling	ukm-126782019-03-17T12:03:50Z http://journalarticle.ukm.my/12678/ Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study Rossman H, Mahathar AW, Nik Azlan Nik Muhamad, Fluid replacement is the mainstay treatment for diabetic ketoacidosis (DKA). Currently, the best choice of fluids is still debatable. An amount of 0.9% sodium chloride is commonly used. Sterofundin® is an alternative crystalloid that is assumed to expedite resolution of acidosis. Advantages in sterofundin content being smaller significant ion difference (SID) to plasma and lower chloride content. The main objective of the study was to compare rate of acidosis resolution in DKA patients between treatment with 0.9% normal saline and Sterofundin over 12 hrs. Other objectives were to compare significant ion difference (SID), 12-hr blood ketone clearance and electrolyte balance between the two groups. The study was a prospective open labelled randomized control trial. This study was conducted over 6 months. Sample size of 18 was obtained with 9 for each arm. Main difference between two groups was initial median 2-hr pH level improvement (NS = +0.006 vs. Sterofundin = +0.05, P=0.063), however not being significant. Ketone, anion gap reduction, bicarbonate normalisation, sodium, chloride, urea and creatinine levels failed to show any significant differences between both groups. Twelve-hour median chloride levels increments were higher in the NS group (+11) compared to the sterofundin group (+6). There was no difference between mortality and morbidity. Comparing the two fluid groups, there was no significant biochemical differences during treatment of DKA. This was a pilot study that can initiate further clinical trials. Pusat Perubatan Universiti Kebangsaan Malaysia 2017 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12678/1/3_rossman_et_al_pdf_57811.pdf Rossman H, and Mahathar AW, and Nik Azlan Nik Muhamad, (2017) Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study. Medicine & Health, 12 (2). pp. 179-192. ISSN 2289-5728 http://www.medicineandhealthukm.com/toc/12/2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Fluid replacement is the mainstay treatment for diabetic ketoacidosis (DKA). Currently, the best choice of fluids is still debatable. An amount of 0.9% sodium chloride is commonly used. Sterofundin® is an alternative crystalloid that is assumed to expedite resolution of acidosis. Advantages in sterofundin content being smaller significant ion difference (SID) to plasma and lower chloride content. The main objective of the study was to compare rate of acidosis resolution in DKA patients between treatment with 0.9% normal saline and Sterofundin over 12 hrs. Other objectives were to compare significant ion difference (SID), 12-hr blood ketone clearance and electrolyte balance between the two groups. The study was a prospective open labelled randomized control trial. This study was conducted over 6 months. Sample size of 18 was obtained with 9 for each arm. Main difference between two groups was initial median 2-hr pH level improvement (NS = +0.006 vs. Sterofundin = +0.05, P=0.063), however not being significant. Ketone, anion gap reduction, bicarbonate normalisation, sodium, chloride, urea and creatinine levels failed to show any significant differences between both groups. Twelve-hour median chloride levels increments were higher in the NS group (+11) compared to the sterofundin group (+6). There was no difference between mortality and morbidity. Comparing the two fluid groups, there was no significant biochemical differences during treatment of DKA. This was a pilot study that can initiate further clinical trials.
format	Article
author	Rossman H, Mahathar AW, Nik Azlan Nik Muhamad,
spellingShingle	Rossman H, Mahathar AW, Nik Azlan Nik Muhamad, Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study
author_facet	Rossman H, Mahathar AW, Nik Azlan Nik Muhamad,
author_sort	Rossman H,
title	Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study
title_short	Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study
title_full	Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study
title_fullStr	Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study
title_full_unstemmed	Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study
title_sort	comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study
publisher	Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate	2017
url	http://journalarticle.ukm.my/12678/ http://journalarticle.ukm.my/12678/ http://journalarticle.ukm.my/12678/1/3_rossman_et_al_pdf_57811.pdf
first_indexed	2023-09-18T20:03:09Z
last_indexed	2023-09-18T20:03:09Z
_version_	1777406982756499456

Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study

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