The physiological, biochemical and quality of life changes in chronic diabetic foot ulcer after hyperbaric oxygen therapy

Hyperbaric oxygen therapy (HBOT) was established to increase oxygenation and antimicrobial effect that potentially improve the healing of chronic ulcer. Present study aim to assess the effects of HBOT in chronic diabetic foot ulcer (DFU). A total of sixty patients classified according to Wagner 1, 2...

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Main Authors:	Mohd Yazid Bajuri, Ayesyah A, Nurhanani Ab, Mohd Rohaizat Hassan
Format:	Article
Language:	English
Published:	Pusat Perubatan Universiti Kebangsaan Malaysia 2017
Online Access:	http://journalarticle.ukm.my/12681/ http://journalarticle.ukm.my/12681/ http://journalarticle.ukm.my/12681/1/6_yazid_et_al_pdf_21204.pdf

id	ukm-12681
recordtype	eprints
spelling	ukm-126812019-03-17T12:09:42Z http://journalarticle.ukm.my/12681/ The physiological, biochemical and quality of life changes in chronic diabetic foot ulcer after hyperbaric oxygen therapy Mohd Yazid Bajuri, Ayesyah A, Nurhanani Ab, Mohd Rohaizat Hassan, Hyperbaric oxygen therapy (HBOT) was established to increase oxygenation and antimicrobial effect that potentially improve the healing of chronic ulcer. Present study aim to assess the effects of HBOT in chronic diabetic foot ulcer (DFU). A total of sixty patients classified according to Wagner 1, 2 or 3 chronic diabetic foot ulcers, were recruited and subsequently divided randomly into two groups; HBOT and control group. All patients underwent the standard treatment for DFU, but for the HBOT group, underwent 20 HBOT sessions, each lasted 80 – 90 mins at 2.5 atmospheres absolute (ATA). White cell count (WCC) and C-reactive protein (CRP) levels were taken during inclusion, at second and fourth week of treatment. Wound sizes were documented at each follow up until six months follow up. SF-36 at one-month post hyperbaric oxygen therapy was used to measure the health-related quality of life. Reduction of WCC and CRP in HBOT group were significant throughout the treatment (p=0.046 and p=0.039, respectively). A total of 26 patients (86.7%) from the HBOT group achieved complete ulcer healing at six months’ follow-up, while 18 patients (60%) in the control group’s ulcer healed completely. Patients treated with HBOT had significantly better mental and physical health constituent of quality of life. It must be emphasised that HBOT is an adjunctive therapy to the standard management of chronic DFU in accelerating wound healing for a better quality of life. Pusat Perubatan Universiti Kebangsaan Malaysia 2017 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12681/1/6_yazid_et_al_pdf_21204.pdf Mohd Yazid Bajuri, and Ayesyah A, and Nurhanani Ab, and Mohd Rohaizat Hassan, (2017) The physiological, biochemical and quality of life changes in chronic diabetic foot ulcer after hyperbaric oxygen therapy. Medicine & Health, 12 (2). pp. 210-219. ISSN 2289-5728 http://www.medicineandhealthukm.com/toc/12/2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Hyperbaric oxygen therapy (HBOT) was established to increase oxygenation and antimicrobial effect that potentially improve the healing of chronic ulcer. Present study aim to assess the effects of HBOT in chronic diabetic foot ulcer (DFU). A total of sixty patients classified according to Wagner 1, 2 or 3 chronic diabetic foot ulcers, were recruited and subsequently divided randomly into two groups; HBOT and control group. All patients underwent the standard treatment for DFU, but for the HBOT group, underwent 20 HBOT sessions, each lasted 80 – 90 mins at 2.5 atmospheres absolute (ATA). White cell count (WCC) and C-reactive protein (CRP) levels were taken during inclusion, at second and fourth week of treatment. Wound sizes were documented at each follow up until six months follow up. SF-36 at one-month post hyperbaric oxygen therapy was used to measure the health-related quality of life. Reduction of WCC and CRP in HBOT group were significant throughout the treatment (p=0.046 and p=0.039, respectively). A total of 26 patients (86.7%) from the HBOT group achieved complete ulcer healing at six months’ follow-up, while 18 patients (60%) in the control group’s ulcer healed completely. Patients treated with HBOT had significantly better mental and physical health constituent of quality of life. It must be emphasised that HBOT is an adjunctive therapy to the standard management of chronic DFU in accelerating wound healing for a better quality of life.
format	Article
author	Mohd Yazid Bajuri, Ayesyah A, Nurhanani Ab, Mohd Rohaizat Hassan,
spellingShingle	Mohd Yazid Bajuri, Ayesyah A, Nurhanani Ab, Mohd Rohaizat Hassan, The physiological, biochemical and quality of life changes in chronic diabetic foot ulcer after hyperbaric oxygen therapy
author_facet	Mohd Yazid Bajuri, Ayesyah A, Nurhanani Ab, Mohd Rohaizat Hassan,
author_sort	Mohd Yazid Bajuri,
title	The physiological, biochemical and quality of life changes in chronic diabetic foot ulcer after hyperbaric oxygen therapy
title_short	The physiological, biochemical and quality of life changes in chronic diabetic foot ulcer after hyperbaric oxygen therapy
title_full	The physiological, biochemical and quality of life changes in chronic diabetic foot ulcer after hyperbaric oxygen therapy
title_fullStr	The physiological, biochemical and quality of life changes in chronic diabetic foot ulcer after hyperbaric oxygen therapy
title_full_unstemmed	The physiological, biochemical and quality of life changes in chronic diabetic foot ulcer after hyperbaric oxygen therapy
title_sort	physiological, biochemical and quality of life changes in chronic diabetic foot ulcer after hyperbaric oxygen therapy
publisher	Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate	2017
url	http://journalarticle.ukm.my/12681/ http://journalarticle.ukm.my/12681/ http://journalarticle.ukm.my/12681/1/6_yazid_et_al_pdf_21204.pdf
first_indexed	2023-09-18T20:03:09Z
last_indexed	2023-09-18T20:03:09Z
_version_	1777406983196901376

The physiological, biochemical and quality of life changes in chronic diabetic foot ulcer after hyperbaric oxygen therapy

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