Study of association of TGF-ß1 polymorphism with breast density in a tertiary medical center of Malaysia

Early detection of breast cancer risk by screening tools such as mammography can reduces the cost of treatment management and the prognosis of the disease. The level of breast density of in mammogram is one of the potential cofounder factor for breast cancer risk. The development of mammary epitheli...

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Main Authors:	Wan Rohani Wan Taib, Amiratul Athirah S, Nasriah A, Mohaslida M, Tengku Fatimah Murniwati TM, Norhasiza MJ, Husbani Mar, Elinah A
Format:	Article
Language:	English
Published:	Pusat Perubatan Universiti Kebangsaan Malaysia 2017
Online Access:	http://journalarticle.ukm.my/12692/ http://journalarticle.ukm.my/12692/ http://journalarticle.ukm.my/12692/1/15_wan_rohani_et_al_pdf_12814.pdf

id	ukm-12692
recordtype	eprints
spelling	ukm-126922019-03-17T12:22:40Z http://journalarticle.ukm.my/12692/ Study of association of TGF-ß1 polymorphism with breast density in a tertiary medical center of Malaysia Wan Rohani Wan Taib, Amiratul Athirah S, Nasriah A, Mohaslida M, Tengku Fatimah Murniwati TM, Norhasiza MJ, Husbani Mar, Elinah A, Early detection of breast cancer risk by screening tools such as mammography can reduces the cost of treatment management and the prognosis of the disease. The level of breast density of in mammogram is one of the potential cofounder factor for breast cancer risk. The development of mammary epithelial cells is determined by the genetic factor. Transforming growth factor-beta (TGF-ß) gene involves in the regulation of cell proliferation and cell division. This study aimed to assess the association of TGF-ß1 polymorphisms with breast density among women who underwent breast screening using mammogram. The detection of genotypes for three polymorphisms of TGF-ß1 assigned as rs1800469, rs1800470 and rs4803455 were performed using PCR-RFLP technique. The allele and genotype frequencies were calculated for control group that consists of BIRADS 1 and BIRADS 2 class whilst case group consisted of BIRADS 3 and BIRADS 4 class. Two polymorphisms (rs1800469 and rs1800470) yielded a significant association with breast density with p value of 0.004 and 0.003, respectively. However, the third polymorphism, rs4803455 did not yield a significant association (p value=0.090). Haplotype association analysis might suggest the haplotype GAA conferred susceptibility (p value= 0.02, OR=2.21[1.07-4.55]) rather than haplotype AAC predispose a protective effect (p value=0.004, OR=0.40[0.21-0.77]) to breast density development. This preliminary data on single and haplotype association might reveal the association of polymorphisms of TGF-ß1 with breast density and give an insight on the role of polymorphism in predisposing to breast density development. Pusat Perubatan Universiti Kebangsaan Malaysia 2017 Article NonPeerReviewed application/pdf en http://journalarticle.ukm.my/12692/1/15_wan_rohani_et_al_pdf_12814.pdf Wan Rohani Wan Taib, and Amiratul Athirah S, and Nasriah A, and Mohaslida M, and Tengku Fatimah Murniwati TM, and Norhasiza MJ, and Husbani Mar, and Elinah A, (2017) Study of association of TGF-ß1 polymorphism with breast density in a tertiary medical center of Malaysia. Medicine & Health, 12 (2). pp. 312-320. ISSN 2289-5728 http://www.medicineandhealthukm.com/toc/12/2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Early detection of breast cancer risk by screening tools such as mammography can reduces the cost of treatment management and the prognosis of the disease. The level of breast density of in mammogram is one of the potential cofounder factor for breast cancer risk. The development of mammary epithelial cells is determined by the genetic factor. Transforming growth factor-beta (TGF-ß) gene involves in the regulation of cell proliferation and cell division. This study aimed to assess the association of TGF-ß1 polymorphisms with breast density among women who underwent breast screening using mammogram. The detection of genotypes for three polymorphisms of TGF-ß1 assigned as rs1800469, rs1800470 and rs4803455 were performed using PCR-RFLP technique. The allele and genotype frequencies were calculated for control group that consists of BIRADS 1 and BIRADS 2 class whilst case group consisted of BIRADS 3 and BIRADS 4 class. Two polymorphisms (rs1800469 and rs1800470) yielded a significant association with breast density with p value of 0.004 and 0.003, respectively. However, the third polymorphism, rs4803455 did not yield a significant association (p value=0.090). Haplotype association analysis might suggest the haplotype GAA conferred susceptibility (p value= 0.02, OR=2.21[1.07-4.55]) rather than haplotype AAC predispose a protective effect (p value=0.004, OR=0.40[0.21-0.77]) to breast density development. This preliminary data on single and haplotype association might reveal the association of polymorphisms of TGF-ß1 with breast density and give an insight on the role of polymorphism in predisposing to breast density development.
format	Article
author	Wan Rohani Wan Taib, Amiratul Athirah S, Nasriah A, Mohaslida M, Tengku Fatimah Murniwati TM, Norhasiza MJ, Husbani Mar, Elinah A,
spellingShingle	Wan Rohani Wan Taib, Amiratul Athirah S, Nasriah A, Mohaslida M, Tengku Fatimah Murniwati TM, Norhasiza MJ, Husbani Mar, Elinah A, Study of association of TGF-ß1 polymorphism with breast density in a tertiary medical center of Malaysia
author_facet	Wan Rohani Wan Taib, Amiratul Athirah S, Nasriah A, Mohaslida M, Tengku Fatimah Murniwati TM, Norhasiza MJ, Husbani Mar, Elinah A,
author_sort	Wan Rohani Wan Taib,
title	Study of association of TGF-ß1 polymorphism with breast density in a tertiary medical center of Malaysia
title_short	Study of association of TGF-ß1 polymorphism with breast density in a tertiary medical center of Malaysia
title_full	Study of association of TGF-ß1 polymorphism with breast density in a tertiary medical center of Malaysia
title_fullStr	Study of association of TGF-ß1 polymorphism with breast density in a tertiary medical center of Malaysia
title_full_unstemmed	Study of association of TGF-ß1 polymorphism with breast density in a tertiary medical center of Malaysia
title_sort	study of association of tgf-ß1 polymorphism with breast density in a tertiary medical center of malaysia
publisher	Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate	2017
url	http://journalarticle.ukm.my/12692/ http://journalarticle.ukm.my/12692/ http://journalarticle.ukm.my/12692/1/15_wan_rohani_et_al_pdf_12814.pdf
first_indexed	2023-09-18T20:03:10Z
last_indexed	2023-09-18T20:03:10Z
_version_	1777406984535932928

Study of association of TGF-ß1 polymorphism with breast density in a tertiary medical center of Malaysia

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