Current progress in production of flavonoids using systems and synthetic biology platforms

Flavonoid is an industrially-important compound due to its high pharmaceutical and cosmeceutical values. However, conventional methods in extracting and synthesizing flavonoids are costly, laborious and not sustainable due to small amount of natural flavonoids, large amounts of chemicals and space u...

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Main Authors:	Ku Nurul Aqmar Ku Bahaudin, Suriana Sabri, Ahmad Bazli Ramzi, Leow Thean Chor, Adam Thean Chor, Tewin Tencomnao, Syarul Nataqain Baharum
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/12930/ http://journalarticle.ukm.my/12930/ http://journalarticle.ukm.my/12930/1/18%20Ku%20Nurul%20Aqmar%20Ku%20Bahaudin.pdf

id	ukm-12930
recordtype	eprints
spelling	ukm-129302019-05-15T11:09:17Z http://journalarticle.ukm.my/12930/ Current progress in production of flavonoids using systems and synthetic biology platforms Ku Nurul Aqmar Ku Bahaudin, Suriana Sabri, Ahmad Bazli Ramzi, Leow Thean Chor, Adam Thean Chor Tewin Tencomnao, Syarul Nataqain Baharum, Flavonoid is an industrially-important compound due to its high pharmaceutical and cosmeceutical values. However, conventional methods in extracting and synthesizing flavonoids are costly, laborious and not sustainable due to small amount of natural flavonoids, large amounts of chemicals and space used. Biotechnological production of flavonoids represents a viable and sustainable route especially through the use of metabolic engineering strategies in microbial production hosts. In this review, we will highlight recent strategies for the improving the production of flavonoids using synthetic biology approaches in particular the innovative strategies of genetically-encoded biosensors for in vivo metabolite analysis and high-throughput screening methods using fluorescence-activated cell sorting (FACS). Implementation of transcription factor based-biosensor for microbial flavonoid production and integration of systems and synthetic biology approaches for natural product development will also be discussed. Penerbit Universiti Kebangsaan Malaysia 2018-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12930/1/18%20Ku%20Nurul%20Aqmar%20Ku%20Bahaudin.pdf Ku Nurul Aqmar Ku Bahaudin, and Suriana Sabri, and Ahmad Bazli Ramzi, and Leow Thean Chor, Adam Thean Chor and Tewin Tencomnao, and Syarul Nataqain Baharum, (2018) Current progress in production of flavonoids using systems and synthetic biology platforms. Sains Malaysiana, 47 (12). pp. 3077-3084. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid47bil12_2018/KandunganJilid47Bil12_2018.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Flavonoid is an industrially-important compound due to its high pharmaceutical and cosmeceutical values. However, conventional methods in extracting and synthesizing flavonoids are costly, laborious and not sustainable due to small amount of natural flavonoids, large amounts of chemicals and space used. Biotechnological production of flavonoids represents a viable and sustainable route especially through the use of metabolic engineering strategies in microbial production hosts. In this review, we will highlight recent strategies for the improving the production of flavonoids using synthetic biology approaches in particular the innovative strategies of genetically-encoded biosensors for in vivo metabolite analysis and high-throughput screening methods using fluorescence-activated cell sorting (FACS). Implementation of transcription factor based-biosensor for microbial flavonoid production and integration of systems and synthetic biology approaches for natural product development will also be discussed.
format	Article
author	Ku Nurul Aqmar Ku Bahaudin, Suriana Sabri, Ahmad Bazli Ramzi, Leow Thean Chor, Adam Thean Chor Tewin Tencomnao, Syarul Nataqain Baharum,
spellingShingle	Ku Nurul Aqmar Ku Bahaudin, Suriana Sabri, Ahmad Bazli Ramzi, Leow Thean Chor, Adam Thean Chor Tewin Tencomnao, Syarul Nataqain Baharum, Current progress in production of flavonoids using systems and synthetic biology platforms
author_facet	Ku Nurul Aqmar Ku Bahaudin, Suriana Sabri, Ahmad Bazli Ramzi, Leow Thean Chor, Adam Thean Chor Tewin Tencomnao, Syarul Nataqain Baharum,
author_sort	Ku Nurul Aqmar Ku Bahaudin,
title	Current progress in production of flavonoids using systems and synthetic biology platforms
title_short	Current progress in production of flavonoids using systems and synthetic biology platforms
title_full	Current progress in production of flavonoids using systems and synthetic biology platforms
title_fullStr	Current progress in production of flavonoids using systems and synthetic biology platforms
title_full_unstemmed	Current progress in production of flavonoids using systems and synthetic biology platforms
title_sort	current progress in production of flavonoids using systems and synthetic biology platforms
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/12930/ http://journalarticle.ukm.my/12930/ http://journalarticle.ukm.my/12930/1/18%20Ku%20Nurul%20Aqmar%20Ku%20Bahaudin.pdf
first_indexed	2023-09-18T20:03:42Z
last_indexed	2023-09-18T20:03:42Z
_version_	1777407018153279488

Current progress in production of flavonoids using systems and synthetic biology platforms

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