Assessment of cytotoxicity potency of paclitaxel in combination with Clinacanthus Nutans extracts on human MDA-MB-231 breast cancer cells

Assessment of cytotoxicity potency of paclitaxel in combination with Clinacanthus Nutans extracts on human MDA-MB-231 breast cancer cells

Clinacanthus nutans (C. nutans) leaf extracts have been widely used by cancer patients in Malaysia and local practice claims a cure to cancer. There were several studies done to determine the cytotoxicity potency of C. nutans extracts on various types of cells. However, there is still lacking on the...

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Main Authors: Nur Hasnieza Mohd Rosli, Chan, Kok Meng, Fariza Juliana Nordin, Lek, Mun Leong, Nur Syazwani Abdul Aziz, Nor Fadilah Rajab
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:http://journalarticle.ukm.my/12946/
http://journalarticle.ukm.my/12946/
http://journalarticle.ukm.my/12946/1/24046-76986-1-PB.pdf
id ukm-12946
recordtype eprints
spelling ukm-129462019-05-17T14:41:22Z http://journalarticle.ukm.my/12946/ Assessment of cytotoxicity potency of paclitaxel in combination with Clinacanthus Nutans extracts on human MDA-MB-231 breast cancer cells Nur Hasnieza Mohd Rosli, Chan, Kok Meng Fariza Juliana Nordin, Lek, Mun Leong Nur Syazwani Abdul Aziz, Nor Fadilah Rajab, Clinacanthus nutans (C. nutans) leaf extracts have been widely used by cancer patients in Malaysia and local practice claims a cure to cancer. There were several studies done to determine the cytotoxicity potency of C. nutans extracts on various types of cells. However, there is still lacking on the knowledge regarding the combination effect of C. nutans with anticancer drugs. Thus, the study was carried out to determine the cytotoxicity potency of C. nutans extracts and paclitaxel (PTX) alone and, in combination on MDA-MB-231 cells. The cells were treated with 100% ethanol extract of C. nutans (CNE) and water extract of C. nutans (CNA), PTX and combination of both extracts and PTX for 72 hours and the cytotoxic activity was determined using SRB assay. Result showed that CNE had little cytotoxic activity, whereas CNA showed no cytotoxic activity on MDA-MB-231 cells. For combination treatment of C. nutans extracts and PTX, only CNE showed significant enhanced PTX-induced cytotoxicity (p < 0.05), meanwhile CNA inhibited PTX-induced cytotoxicity significantly (p < 0.05). As a conclusion, CNE was able to increase PTX potency to inhibit the viability of MDA-MB-231 cells. Penerbit Universiti Kebangsaan Malaysia 2018 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12946/1/24046-76986-1-PB.pdf Nur Hasnieza Mohd Rosli, and Chan, Kok Meng and Fariza Juliana Nordin, and Lek, Mun Leong and Nur Syazwani Abdul Aziz, and Nor Fadilah Rajab, (2018) Assessment of cytotoxicity potency of paclitaxel in combination with Clinacanthus Nutans extracts on human MDA-MB-231 breast cancer cells. Jurnal Sains Kesihatan Malaysia, 16 (SI). pp. 95-103. ISSN 1675-8161 http://ejournal.ukm.my/jskm/issue/view/1072
repository_type Digital Repository
institution_category Local University
institution Universiti Kebangasaan Malaysia
building UKM Institutional Repository
collection Online Access
language English
description Clinacanthus nutans (C. nutans) leaf extracts have been widely used by cancer patients in Malaysia and local practice claims a cure to cancer. There were several studies done to determine the cytotoxicity potency of C. nutans extracts on various types of cells. However, there is still lacking on the knowledge regarding the combination effect of C. nutans with anticancer drugs. Thus, the study was carried out to determine the cytotoxicity potency of C. nutans extracts and paclitaxel (PTX) alone and, in combination on MDA-MB-231 cells. The cells were treated with 100% ethanol extract of C. nutans (CNE) and water extract of C. nutans (CNA), PTX and combination of both extracts and PTX for 72 hours and the cytotoxic activity was determined using SRB assay. Result showed that CNE had little cytotoxic activity, whereas CNA showed no cytotoxic activity on MDA-MB-231 cells. For combination treatment of C. nutans extracts and PTX, only CNE showed significant enhanced PTX-induced cytotoxicity (p < 0.05), meanwhile CNA inhibited PTX-induced cytotoxicity significantly (p < 0.05). As a conclusion, CNE was able to increase PTX potency to inhibit the viability of MDA-MB-231 cells.
format Article
author Nur Hasnieza Mohd Rosli,
Chan, Kok Meng
Fariza Juliana Nordin,
Lek, Mun Leong
Nur Syazwani Abdul Aziz,
Nor Fadilah Rajab,
spellingShingle Nur Hasnieza Mohd Rosli,
Chan, Kok Meng
Fariza Juliana Nordin,
Lek, Mun Leong
Nur Syazwani Abdul Aziz,
Nor Fadilah Rajab,
Assessment of cytotoxicity potency of paclitaxel in combination with Clinacanthus Nutans extracts on human MDA-MB-231 breast cancer cells
author_facet Nur Hasnieza Mohd Rosli,
Chan, Kok Meng
Fariza Juliana Nordin,
Lek, Mun Leong
Nur Syazwani Abdul Aziz,
Nor Fadilah Rajab,
author_sort Nur Hasnieza Mohd Rosli,
title Assessment of cytotoxicity potency of paclitaxel in combination with Clinacanthus Nutans extracts on human MDA-MB-231 breast cancer cells
title_short Assessment of cytotoxicity potency of paclitaxel in combination with Clinacanthus Nutans extracts on human MDA-MB-231 breast cancer cells
title_full Assessment of cytotoxicity potency of paclitaxel in combination with Clinacanthus Nutans extracts on human MDA-MB-231 breast cancer cells
title_fullStr Assessment of cytotoxicity potency of paclitaxel in combination with Clinacanthus Nutans extracts on human MDA-MB-231 breast cancer cells
title_full_unstemmed Assessment of cytotoxicity potency of paclitaxel in combination with Clinacanthus Nutans extracts on human MDA-MB-231 breast cancer cells
title_sort assessment of cytotoxicity potency of paclitaxel in combination with clinacanthus nutans extracts on human mda-mb-231 breast cancer cells
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2018
url http://journalarticle.ukm.my/12946/
http://journalarticle.ukm.my/12946/
http://journalarticle.ukm.my/12946/1/24046-76986-1-PB.pdf
first_indexed 2023-09-18T20:03:45Z
last_indexed 2023-09-18T20:03:45Z
_version_ 1777407020503138304

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