Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer

The invasion of cancer cells into the peritumoral, lymph node and perineural system could be detrimental on cancer patients. In colorectal cancer (CRC) patients, the presence of lymphovascular (LVI) and/or perineural (PNI) invasion could significantly influence on the survival rates, treatment optio...

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Main Authors:	Nadiah Abu, Nurul-Syakima Ab Mutalib, Rahman Jamal
Format:	Article
Language:	English
Published:	Pusat Perubatan Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/13246/ http://journalarticle.ukm.my/13246/ http://journalarticle.ukm.my/13246/1/35-137-1-PB.pdf

id	ukm-13246
recordtype	eprints
spelling	ukm-132462019-08-02T04:20:10Z http://journalarticle.ukm.my/13246/ Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer Nadiah Abu, Nurul-Syakima Ab Mutalib, Rahman Jamal, The invasion of cancer cells into the peritumoral, lymph node and perineural system could be detrimental on cancer patients. In colorectal cancer (CRC) patients, the presence of lymphovascular (LVI) and/or perineural (PNI) invasion could significantly influence on the survival rates, treatment options and recurrence tendencies. To date, no study has analyzed the molecular profile of the concomitant existence of LVI and PNI in CRC. Here, we reanalyzed The Cancer Genome Atlas (TCGA) CRC datasets and focused on cases where the information regarding LVI and PNI are available (n=176). We performed differential gene expression, methylation and microRNA analysis by comparing the groups having both or either LVI and PNI with the control group (LVI negative and PNI negative). Although there was no significant difference in the methylation and miRNA profiles, we identified a number of differentially expressed genes (DEGs). The comparison between the LVI+PNI+ and LVI-PNI- groups revealed key DEGs including SFTA2, PHACTR3, CRABP2, ODZ3, GRP, HAP1, CSDC2, TMEM59L and HDAC9. Meanwhile, in the LVI-PNI+ vs LVI-PNI- group, some of the DEGs found were PTPRR, EFNA2, FGF20, IGFL4, METRN and IGFBPL1. We believe that this study could be beneficial and add value to further understand the complex molecular profiles of CRC. Pusat Perubatan Universiti Kebangsaan Malaysia 2018 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/13246/1/35-137-1-PB.pdf Nadiah Abu, and Nurul-Syakima Ab Mutalib, and Rahman Jamal, (2018) Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer. Asia-Pacific Journal of Molecular Medicine, 8 (2). pp. 1-13. ISSN 2232-0326 http://spaj.ukm.my/apjmm/index.php/apjmm/issue/view/19
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The invasion of cancer cells into the peritumoral, lymph node and perineural system could be detrimental on cancer patients. In colorectal cancer (CRC) patients, the presence of lymphovascular (LVI) and/or perineural (PNI) invasion could significantly influence on the survival rates, treatment options and recurrence tendencies. To date, no study has analyzed the molecular profile of the concomitant existence of LVI and PNI in CRC. Here, we reanalyzed The Cancer Genome Atlas (TCGA) CRC datasets and focused on cases where the information regarding LVI and PNI are available (n=176). We performed differential gene expression, methylation and microRNA analysis by comparing the groups having both or either LVI and PNI with the control group (LVI negative and PNI negative). Although there was no significant difference in the methylation and miRNA profiles, we identified a number of differentially expressed genes (DEGs). The comparison between the LVI+PNI+ and LVI-PNI- groups revealed key DEGs including SFTA2, PHACTR3, CRABP2, ODZ3, GRP, HAP1, CSDC2, TMEM59L and HDAC9. Meanwhile, in the LVI-PNI+ vs LVI-PNI- group, some of the DEGs found were PTPRR, EFNA2, FGF20, IGFL4, METRN and IGFBPL1. We believe that this study could be beneficial and add value to further understand the complex molecular profiles of CRC.
format	Article
author	Nadiah Abu, Nurul-Syakima Ab Mutalib, Rahman Jamal,
spellingShingle	Nadiah Abu, Nurul-Syakima Ab Mutalib, Rahman Jamal, Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
author_facet	Nadiah Abu, Nurul-Syakima Ab Mutalib, Rahman Jamal,
author_sort	Nadiah Abu,
title	Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
title_short	Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
title_full	Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
title_fullStr	Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
title_full_unstemmed	Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
title_sort	gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
publisher	Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/13246/ http://journalarticle.ukm.my/13246/ http://journalarticle.ukm.my/13246/1/35-137-1-PB.pdf
first_indexed	2023-09-18T20:04:25Z
last_indexed	2023-09-18T20:04:25Z
_version_	1777407063142432768

Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer

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