Blood inflammatory markers, anabolic hormone, vitamin D and L-carnitine status according to frailty status among older adults

Frailty is associated with functional decline and reduced ability to cope with physiological challenges. The pathophysiological changes in frailty include inflammation, endocrine disturbances, neuromuscular and immune dysfunction. However, comprehensive information on the relationship between biolog...

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Main Authors:	Manal Badrasawi, Suzana Shahar, Nor Fadilah Rajab, Devinder Kaur Ajit Singh
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:	http://journalarticle.ukm.my/13320/ http://journalarticle.ukm.my/13320/ http://journalarticle.ukm.my/13320/1/14%20Manal%20Badrasawi.pdf

id	ukm-13320
recordtype	eprints
spelling	ukm-133202019-08-29T21:37:02Z http://journalarticle.ukm.my/13320/ Blood inflammatory markers, anabolic hormone, vitamin D and L-carnitine status according to frailty status among older adults Manal Badrasawi, Suzana Shahar, Nor Fadilah Rajab, Devinder Kaur Ajit Singh, Frailty is associated with functional decline and reduced ability to cope with physiological challenges. The pathophysiological changes in frailty include inflammation, endocrine disturbances, neuromuscular and immune dysfunction. However, comprehensive information on the relationship between biological markers and frailty is scarce. We aimed to determine the relationship between selected biomarkers and frailty among Malaysian older adults. In this cross sectional study, 600 community dwelling older adults were randomly selected from ten different areas in Klang Valley. A total of 382 participants met the inclusion criteria and consented to the study. Out of these, a subsamples of 91 participants were selected for biomarkers analysis. Frailty was defined using Fried’s criteria. Fasting blood glucose, lipid profile, albumin, selected frailty biomarkers including IL-6, TNF- alpha and IGF-1 and vitamin D together with free L-carnitine and acetyl L-carnitine were analysed. The results showed a significantly higher level of serum IL-6 and TNF-α among participants classified as frail as compared to pre-frail and robust (p<0.05). With respect to nutritional biomarkers, binary logistic regression showed that vitamin D deficiency is associated with three times higher risk of frailty (p<0.05). There was no significant relationship between blood L-carnitines and frailty. Further research is required to explore the relationship between L-carnitine and frailty using different parameters involved in L-carnitine homeostasis such as CPTII enzyme and OCTN2 mutation. In conclusion, frailty was associated with increased level of inflammatory markers and vitamin D deficiency. It is empirical to promote healthy lifestyle or disease management to reduce inflammation and increase vitamin D status as one of the frailty prevention action plan among older adults. Penerbit Universiti Kebangsaan Malaysia 2019-03 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/13320/1/14%20Manal%20Badrasawi.pdf Manal Badrasawi, and Suzana Shahar, and Nor Fadilah Rajab, and Devinder Kaur Ajit Singh, (2019) Blood inflammatory markers, anabolic hormone, vitamin D and L-carnitine status according to frailty status among older adults. Sains Malaysiana, 48 (3). pp. 613-619. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil3_2019/KandunganJilid48Bil3_2019.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Frailty is associated with functional decline and reduced ability to cope with physiological challenges. The pathophysiological changes in frailty include inflammation, endocrine disturbances, neuromuscular and immune dysfunction. However, comprehensive information on the relationship between biological markers and frailty is scarce. We aimed to determine the relationship between selected biomarkers and frailty among Malaysian older adults. In this cross sectional study, 600 community dwelling older adults were randomly selected from ten different areas in Klang Valley. A total of 382 participants met the inclusion criteria and consented to the study. Out of these, a subsamples of 91 participants were selected for biomarkers analysis. Frailty was defined using Fried’s criteria. Fasting blood glucose, lipid profile, albumin, selected frailty biomarkers including IL-6, TNF- alpha and IGF-1 and vitamin D together with free L-carnitine and acetyl L-carnitine were analysed. The results showed a significantly higher level of serum IL-6 and TNF-α among participants classified as frail as compared to pre-frail and robust (p<0.05). With respect to nutritional biomarkers, binary logistic regression showed that vitamin D deficiency is associated with three times higher risk of frailty (p<0.05). There was no significant relationship between blood L-carnitines and frailty. Further research is required to explore the relationship between L-carnitine and frailty using different parameters involved in L-carnitine homeostasis such as CPTII enzyme and OCTN2 mutation. In conclusion, frailty was associated with increased level of inflammatory markers and vitamin D deficiency. It is empirical to promote healthy lifestyle or disease management to reduce inflammation and increase vitamin D status as one of the frailty prevention action plan among older adults.
format	Article
author	Manal Badrasawi, Suzana Shahar, Nor Fadilah Rajab, Devinder Kaur Ajit Singh,
spellingShingle	Manal Badrasawi, Suzana Shahar, Nor Fadilah Rajab, Devinder Kaur Ajit Singh, Blood inflammatory markers, anabolic hormone, vitamin D and L-carnitine status according to frailty status among older adults
author_facet	Manal Badrasawi, Suzana Shahar, Nor Fadilah Rajab, Devinder Kaur Ajit Singh,
author_sort	Manal Badrasawi,
title	Blood inflammatory markers, anabolic hormone, vitamin D and L-carnitine status according to frailty status among older adults
title_short	Blood inflammatory markers, anabolic hormone, vitamin D and L-carnitine status according to frailty status among older adults
title_full	Blood inflammatory markers, anabolic hormone, vitamin D and L-carnitine status according to frailty status among older adults
title_fullStr	Blood inflammatory markers, anabolic hormone, vitamin D and L-carnitine status according to frailty status among older adults
title_full_unstemmed	Blood inflammatory markers, anabolic hormone, vitamin D and L-carnitine status according to frailty status among older adults
title_sort	blood inflammatory markers, anabolic hormone, vitamin d and l-carnitine status according to frailty status among older adults
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2019
url	http://journalarticle.ukm.my/13320/ http://journalarticle.ukm.my/13320/ http://journalarticle.ukm.my/13320/1/14%20Manal%20Badrasawi.pdf
first_indexed	2023-09-18T20:04:35Z
last_indexed	2023-09-18T20:04:35Z
_version_	1777407073456226304

Blood inflammatory markers, anabolic hormone, vitamin D and L-carnitine status according to frailty status among older adults

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